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Biomedical subjects

G Renou

Publications and source records attributed to G Renou.

At least 19 recordsLinked to original sources
PubMed2002

A prospective, multicentre study of moxifloxacin concentrations in the sinus mucosa tissue of patients undergoing elective surgery of the sinus.

A pharmacokinetic study was carried out to determine moxifloxacin concentrations in sinus tissue, after oral moxifloxacin 400 mg once daily for 5 days to patients with chronic sinusitis, undergoing elective sinus surgery. Patients were randomly allocated to one of seven treatment groups, in which tissues were sampled 2, 3, 4, 6, 12, 24 or 36 h post-dose. A control group with non-infected nasal polyps was also included. Forty-eight patients (13 female, 35 male, mean age 47.1 years) were allocated to one of each active treatment group (n = 42) or to the control group (n = 6). Tissue and plasma samples were taken simultaneously and stored frozen until assayed by HPLC. Thirty-nine patients were fully valid for pharmacokinetic analysis. The geometric mean moxifloxacin plasma concentration increased from 2.32 mg/L at 2 h to a maximum of 3.37 mg/L at 4 h post-dose, decreasing to 0.37 mg/L at 36 h post-dose. The moxifloxacin concentration in sinus mucosa was consistently greater than that in plasma being 4.56-5.73 mg/kg from 2 to 6 h and 2.81-1.25 mg/kg from 12 to 36 h post-dose. The elimination rates in plasma and sinus tissues were similar. The tissue/plasma ratio was c. 200% between 2 and 6 h, and up to 328.9% at 36 h. Results were similar whatever the site of tissue sampling (maxillary sinus, anterior ethmoid sinus or nasal polyps). Tissue levels exceeded the MIC(90) of all pathogens commonly causing acute sinusitis (e.g. 5-30 x MIC for Streptococcus pneumoniae: 0.25 mg/L). These results sup-port the use of moxifloxacin 400 mg once daily as a regimen for the treatment of sinus infections.

Adult↗
PubMed2002

[Drainage after thyroid surgery: 264 patients].

OBJECTIVES: A prospective study was conducted in 1996-1997 in 100 patients who underwent thyroid surgery and who were randomly assigned to receive drainage or not. No statistical difference in complication rate was observed. The aim of the present retrospective study was to assess the consequences of this attitude in patients undergoing surgery since that time and to determine the number of postoperative complications, length of hospital stay, and type of thyroidectomy where cervical drains still appear to be indicated. PATIENTS AND METHODS: Total or partial thyroid surgery was performed in 264 patients between June 1997 and October 2000. Neck dissection was associated with 24 patients. RESULTS: Cervical drains were used in 29 patients (10.9%). Postoperative complications were comparable to those commonly reported. CONCLUSION: Except for neck dissection and mediastinal extension, thyroidectomy can be safely performed without drainage. This attitude reduces the overall hospital stay.

Adult↗
PubMed1999

Drainage after thyroid surgery: a prospective randomized study.

Between November, 1996 and May, 1997 a series of 100 consecutive unselected patients undergoing all types of thyroid surgery--including even those inducing large dead space e.g. substernal goitre and carcinoma thyroid with recurrent nerve dissection--were randomly allotted to either receive drainage (n = 43) or not (n = 57). Patients with cervical dissection for lymph node metastasis were not included. Severe intra-operative haemorrhage was not a reason for exclusion. No complications such as haematoma or seroma were found in the undrained group whereas only minor complications such as haematoma (n = 4) were noted in the drained group. Whatever the group, none of the patients required re-exploration. The difference in overall hospital stay (1.72 days in the group of undrained patients versus 2.09 days in the drained group) was not statistically significant.

Adenoma↗
PubMed1995

[Analysis of complications of thyroid surgery: recurrent paralysis et hypoparathyroidism. On a series of 588 cases].

The purpose of this report is to study the incidence of two main complications in thyroid surgery without systematic search for recurrent laryngeal nerve, by intracapsular thyroidectomy: temporary and chronic laryngeal recurrent paralysis (after six months), temporary hypoparathyroidism and chronic hypoparathyroidism (unrecovering normal function after six months). We have retrospectively analysed 588 patients from 1981 to 1994. There were 247 total or subtotal thyroidectomies and 341 loboisthmectomies (isolated thyroid nodules). We obtained over this 588 cases 0.3% of chronic laryngeal paralysis and 1.4% of chronic hypoparathyroidism. If the cost of surgery for thyroid nodules is low (0.3% of chronic recurrent paralysis and 0% of chronic hypoparathyroidism), it is more important for total or subtotal thyroidectomies (respectively 1.2% and 3.2%). We conclude that in thyroid surgery, there is no higher risk for the recurrent nerve without dissection of this one, but we note that, without obvious explanation, rates of permanent hypoparathyroidism are not better than in others publications.

Humans↗
PubMed1989

[Sudden deafness: apropos of 19 cases. Results of treatment with pentoxifylline. Value of erythrocyte filtration time].

Between March 85 and November 86, 20 patients underwent treatment for sudden deafness [19] or bilateral tinnitus [1] by Pentoxifylline (1 200 mg/24 Hrs, including 400 mg IV over 24 Hrs) and Carbogen sessions (2 or 3/24 Hrs), during six days on an in-patient basis, followed by 1 200 mg/24 Hrs orally during another eight days. The results, assessed by clinical examination, audiometry, and erythrocyte filtration time (using the Reid and Dormandy method) on the first, sixth, and fourtheenth days, were: -- good or very good a little more than 75%, -- moderate: 5%, -- poor: a little fewer than 20%. Filtration times in a group of asymptomatic patients, determined by the same method, were used as a reference.

Adolescent↗
PubMed1989

[Neoplastic development of laryngeal amyloidosis. Apropos of a case].

The authors report the case of a 62 years old patient who presented a squamous laryngeal carcinoma 8 years after the discovery of amyloidosis localized to one vocal cord. In this patient, a relationship would seem to exist between the two pathologies, with degeneration of amyloidosis being responsible, though a random coexistence cannot, of course, be completely excluded. After a review of laryngeal amyloidosis and its management, this particular case is discussed in relation to other cases described in the literature.

Amyloidosis↗
PubMed1989

[Medical treatment of seromucous otitis].

The authors list the main modalities for medical therapy proposed for sero-mucous otitis. Treatments such as antibiotherapy, corticotherapy and antihistamines have not proved to be effective, although they are useful at certain stages of the disease. The authors present a study of a mucolytic, carbocysteine, for the treatment of sero-mucous otitis. The study was performed using a double blind procedure against placebo in 44 children aged from 30 months to ten years. Monitoring included a clinical examination, impedancemetry, and audiometry. With carbocysteine, the auditive recovery was significantly faster on the side of the least affected ear. When transtympanic drainage had to be performed, the mucolytic effect in vivo on the fluidity of the secretions was directly noted. An improved ear evacuation was obtained. Tolerance was perfect in prolonged treatment with a high posology in young children.

Acoustic Impedance Tests↗
PubMed1981

[Hypoglosso-facial anastomosis. Results in 10 cases (author's transl)].

The authors present the results of 10 hypoglosso-facial anastomoses performed according to the technique of J.M. Sterkers and J.M. Pelisse. In 9 cases regularly followed up: - Muscle tone reappeared between 4 and 5 months and was symmetrical in all cases. - Motility of the half of the face was visible between 4 and 7 months after the anastomosis. In 8 cases out of 9 the definitive result was good with muscle testing varying between 17 and 23/30. In one case palpebral occlusion was incomplete with testing at 13/30. Paralysis of one half of the tongue was invariably well tolerated. Hypoglosso-facial anastomosis has the value of reliability superior to other techniques, in particular facio-facial anastomosis.

Facial Muscles↗
PubMed1978

[Topographical diagnosis of facial paralysis (Bell's palsy) (author's transl)].

Topographical diagnosis using Schirmer's test and measurement of the stapes reflex was carried out in a series of 45 cases of Bell's palsy. The aim of this study was to define the exact location of the nerve lesion in order to guide the possible choice of surgical decompression of the facial nerve. The authors noted the existence of a geniculate or suprageniculate lesion in 62% of cases. A study of the literature shows marked disagreement between the various publications. This leads to discussion of the value and interpretation of topographical tests.

Facial Nerve↗