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Biomedical subjects

G Resta

Publications and source records attributed to G Resta.

At least 19 recordsLinked to original sources
PubMed1994

Not so humane.

Explore the source record for details and available documents.

Animal Welfare↗
PubMed1992

A quantitative model for the regulation of naturally occurring cell death in the developing vertebrate nervous system.

Throughout the animal kingdom, the formation of the nervous system involves the elimination of many cells soon after their generation. This phenomenon, known as naturally occurring cell death, has precise time schedules and is observed in the vast majority of neural structures. It causes the loss of 15-85% of the neurons generated. Manipulations of the target structure can considerably affect the amount of cell death in a nervous center, but the regulation of this process is still controversial. While in some experiments cell death leads to a linear relationship between the size of the target and that of the input, other experiments show dramatic deviations from a linear prediction. It is quite possible that cell death is regulated by different mechanisms in different cases and that the search for a single explanation would be doomed to failure. However, it is shown here that if mutual trophic interactions are assumed to occur between connected structures, a general model can be developed for the regulation of histogenetic cell death in the developing nervous system of vertebrates. The model relies on few assumptions, all derived from a number of experimental studies. Cells destined to form a neural center are generated according to a program and die around a certain age unless a trophic factor is supplied that prevents their death. Target cells exert a trophic influence on input cells and vice versa. The model quantitatively describes the time course and the amount of cell death in neural structures, thereby reconciling in a unitary framework experimental findings that until now have appeared conflicting.

Animals↗
PubMed1990

[New methods and new technics in pedodontics: "conscious sedation"!].

The reasons why is it sometimes necessary to resort in paediatric dentistry to the use of conscious sedation with N2O/O2 are explained together with clinical indications and applications. The excellent results obtained with this technique lead to greater cooperation of the child, to a positive emotional contact with dental treatment and the possibility of performing the necessary therapies with greater precision.

Ambulatory Surgical Procedures↗
PubMed1989

Catalase and glutathione peroxidase activity in cells with trisomy 21.

CuZnSOD is produced in overdose in cells with trisomy 21. This has been considered to be a cause of increased oxidative stress. In the present work we have studied the catalase and glutathione peroxidase activity in fibroblasts from 6, and blood cells from 30, subjects affected by Down syndrome. In the fibroblasts, catalase and glutathione peroxidase activities did not differ significantly from control cells. In platelets, lymphocytes, polymorphs and erythrocytes, no significant increase of catalase activity was found while glutathione peroxidase activity appeared significantly increased in platelets, polymorphs and erythrocytes but not in lymphocytes. These data seem to indicate that the increase of CuZnSOD in trisomy 21 cells does not affect the production of catalase. An increase, instead, of glutathione peroxidase has been detected in all blood cells, except in lymphocytes; this is a sign of a greater need for protection against the risk of lipoperoxidation. The fact that the enhancement of glutathione peroxidase activity could be assessed only in some types of cells examined suggests that the observed increase in those cells is probably a result of an additive effect of the overproduction of CuZnSOD due to gene dosage and the ordinarily higher content of oxygen radicals and peroxides.

Adolescent↗
PubMed1989

[Histological and ultrastructural observations of dentin dysplasia type I].

The Authors described a case of dentinal dysplasia type I in one patient (7.6 years). The father also presented the same pathology. The AA. presented the histological and ultra-structural observations, with scansion electron microscopy aut they showed the main aspects of these pathology: pulpal root canal obliterated with dysplastiques dentinal masses, globuliform dentin with irregular form of tubuli and rest of organic pulpar tissue with calcified material.

Child↗
PubMedDate not supplied

[Pregnancy and breast-feeding: developmental stages of mother-child bonding].

Several authors, confronting the mother-child relationship during pregnancy and breast-feeding, talk about an uterine and extra-uterine symbiosis. In this way, one bypasses the fact that the so called unions end with the processes of separation constituted by the birthing/birth (by the termination, that is to say, of the first maternal nurturing (that of placenta) as well as by the termination of the second maternal nurturing (that of the individual breast-feedings). The careful observation of these unions demonstrates that they coexist and they imply equilibrium through the processes of separation that not only allow a partial autonomy of the developments of mother and child, but also make room for the detachments represented by the birthing/birth and by the end of the individual breast feedings. The author is trying to illustrate some physiological and pathological equilibrium between these tendencies towards reciprocal dependence and reciprocal mother-child autonomy.

Breast Feeding↗