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Biomedical subjects

G Reynaud

Publications and source records attributed to G Reynaud.

At least 19 recordsLinked to original sources

[Psychiatric disorders in elderly patients with Parkinson's disease and their treatments].

Parkinson's disease (PD) is a neuropsychiatric disorder. During the course of PD, most patients develop at least one psychiatric syndrome. Depression is the most frequent disorder and affects nearly half of all patients. The use of an increasing number of new drugs, in particular the dopaminergic agents, puts these patients at risk of developing both delirium and psychosis. This article summarizes the different psychiatric syndromes seen in PD and gives an account of the various treatment possibilities.

Age Factors↗

[Safety aspects of the practical application of a gI-negative subunit vaccine against Aujeszky's disease in swine].

On two farms in an area in which Aujeszky's disease is endemic, 192 pregnant sows were vaccinated with a gI-negative sub-unit vaccine against Aujeszky's disease. The rectal temperatures of the sows were recorded once daily for seven consecutive days, starting on the day of vaccination, and the vaccinated animals were observed for local and systemic reactions. The temperatures recorded did not exceed 39.8 degrees C in any case, and local or systemic reactions caused by vaccinations were not observed. One sow (0.6 per cent) aborted, but other symptoms of disease were not apparent, and there was no relationship with vaccination. In a second experiment, the carcasses of 120 pigs, vaccinated once or twice with the same vaccine, were carefully examined for local reactions. In eleven pigs (9.1 per cent) slight cicatricial reactions were visible within from 20 to 34 days after inoculation, the diameter not exceeding 1.5 cm in any of the cases. Traces of vaccination were no longer perceptible within 84 days after vaccination. The vaccine was found to be very safe for pregnant sows under field conditions.

Animals↗

Study of the efficacy of an inactivated virus vaccine against porcine parvovirus.

The efficacy of an inactivated virus vaccine against porcine parvovirus has been studied by immunizing 4 sows during pregnancy. A parvovirus virulent strain has been inoculated to these sows and to two other unvaccinated sows used as controls. The infection was performed between the 52nd and the 57th day of gestation. In the litters born from the vaccinated sows, 82% of the piglets were alive and normal. Neither PPV antibodies nor antigen could be revealed in the stillborn fetuses born from the 4 vaccinated sows. Reversely, only 9.5% of the piglets born from the 2 unvaccinated sows were alive at birth, although they were probably infected during pregnancy. In total, 86% of fetuses in these 2 litters were mummified. A field study allowed to show that the double vaccination antibodies induced, persisted with constant titers for, at least, 13 months. Moreover, the reproductive performance of 413 gilts, vaccinated twice before mating, were not affected by this treatment.

Animals↗

Freeze-dried vaccine against Rinderpest: stability and activity study.

A freeze-dried vaccine against Rinderpest was prepared from modified virus multiplied in calf kidney cell culture. Characteristics of the vaccine are as follows: high titre after freeze-drying (10(4) CCID50/dose), well-adapted freeze-drying stabilizer which ensures maintenance of the infective titre of the vaccinal virus, even under severe conditions (3.5 days at +45 degrees C), use of an appropriate solvent: magnesium sulphate molar solution or more simply physiological saline (for stability after reconstitution even at high temperatures--up to 4 h at +45 degrees C). The activity of the vaccine, tested in cattle by antibody titration and resistance to specific challenge perfectly satisfies requirements set by the WHO and OIE.

Animals↗

[Not Available].

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Demography↗

[Effect of busulfan on the germ cell line of the quail embryo (author's transl)].

Busulfan was injected into the albumen of the quail egg on the 56th hour of incubation. The subjects injected with a high dose (9.6 mg/kg) showed at 15 days of incubation (and 2 days after hatching in the females) a clear cut sexual differentiation of their gonads. The germ cells were degenerating and the ovaries became sterile. 3 out of 4 testes wee sterile. However, the gonads were generally smaller than the normal ones through the flattening of the ovarian cortex or the reduction of the number and size of the testicular cords.

Animals↗

[Not Available].

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Botany↗