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G Roelants

Publications and source records attributed to G Roelants.

6 recordsLinked to original sources
PubMed1990

Genetic organization of a chimpanzee lentivirus related to HIV-1.

Simian immunodeficiency viruses have been isolated from four species of monkey, the 'captive' macaque and mangabey and the 'feral' African green monkey and mandrill. While none of these viruses is a replica of HIV-1, the macaque and mangabey viruses represent correct genetic models for HIV-2, possessing exactly the same complement of genes. Recently a lentivirus has been identified in two wild chimpanzees (Pan troglodytes troglodytes) in Gabon, west equatorial Africa, and isolated from one of them. This virus is referred to as SIVCPZ. Sera from these animals cross reacted with all the HIV-1 proteins including the envelope glycoproteins. Here, we describe the molecular cloning and sequencing of an infectious proviral clone of SIVCPZ. The overall genetic organization was the same as that of HIV-1, but phylogenetic analysis revealed that the sequence was more divergent than any HIV-1 sequence reported so far. The vpu gene product, found only in the type 1 viruses, was particularly different (64% divergent to HIV-1BRU) suggesting that the SIVCPZ represents a distinct subtype. These findings indicate that there is a larger pool of simian lentiviruses than previously suspected and revives debate as to the origins of HIV-1.

Amino Acid Sequence↗
PubMed1986

Incidence of bovine leukemia virus-specific antibodies in West African cattle.

A sero-epidemiological survey of bovine leukemia virus (BLV) infection in indigenous West African cattle was undertaken using a radioimmunoassay and enzyme-linked immunosorbent assay. A high incidence of anti-BLV antibodies was found in the breeds tested and their crosses, whatever the test used. More extensive studies are needed to establish the prevalence of BLV infection in other parts of Africa; these may provide additional data on the similarities found between human and bovine leukemia viruses.

Africa, Western↗
PubMed1978

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Abstracting and Indexing↗