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Biomedical subjects

G Roessler

Publications and source records attributed to G Roessler.

11 recordsLinked to original sources
PubMed2006

[Bilateral anterior panuveitis as early manifestation of syphilis in a patient with HIV infection].

INTRODUCTION: Syphilis is a dangerous sexually transmitted infection which can be effectively treated with penicillin to avoid late-onset diseases. Even if syphilis is diagnosed an HIV infection should be excluded. PATIENT: A 32-year-old homosexual man complained about a decreased bilateral visual acuity after a feverish infection with lymphadenitis colli. With slit-lamp biomicroscopy a bilateral panuveitis with papillary edema, endothelial cells and episcleritis was found. After antimycotic and antiviral therapy, his visual acuity decreased and symptoms progressed. In the lab routine we found lues and HIV infections and started an intravenous penicillin therapy immediately. A few days later the symptoms improved and visual acuity increased. CONCLUSION: Lues serology should be incorporated into routine lab diagnostics to aid the detection and to start the right therapy as soon as possible.

Adult↗
PubMed2004

The retina implant--new approach to a visual prosthesis.

Currently, no treatment is available for degenerative diseases of retinal photoreceptors. The patients are faced with a high risk of blindness. Biological approaches failed to prove efficacy. A new concept for the treatment of disorders like retinitis pigmentosa is electrical stimulation at various levels of the visual system. Therefore, devices were fabricated with stimulating electrodes contacting retinal or central neurons to elicit biological activity in these cells. It became possible to fabricate even complex devices with an external power supply encapsulated within biocompatible materials. Animal experiments showed that with implanted prototypes cortical activation could be achieved and first experiments in blind human subject also suggest that vision can be restored, however at present in a very low range of simply identifying spots of light. Further developments and also the continuation of animal experiments are necessary before the clinical application will become a standard procedure.

Artificial Intelligence↗
PubMed2000

Effects of chemotherapy (busulfan-hydroxyurea) and interferon-alfa on bone marrow morphologic features in chronic myelogenous leukemia. Histochemical and morphometric study on sequential trephine biopsy specimens with special emphasis on dynamic features.

We performed a retrospective clinicopathologic study on sequential biopsy specimens from 90 patients with Philadelphia chromosome-positive chronic myelogenous leukemia to study therapy-specific effects of busulfan (28 patients), hydroxyurea (32 patients), and interferon-alfa (IFN-alfa; 30 patients). Bone marrow specimens were evaluated by morphometry after silver impregnation and staining with monoclonal antibodies to identify reticulin fibers, nucleated erythroid precursors, megakaryocytes, and macrophages. To compute dynamics of histopathology implicating corresponding changes in time, relevant indices were calculated. Quantification of megakaryocytopoiesis and its precursor cell population showed a significant increase in the IFN-alfa and busulfan groups compared with the hydroxyurea group. These changes were associated with a development of myelofibrosis during therapy. Although a significant increase in fiber density was detectable in the busulfan group, the progression index proved to be twice as high after IFN-alfa therapy. In contrast, a considerable number of patients displayed a regression of myelofibrosis after hydroxyurea treatment. The general association of the megakaryocyte lineage with myelofibrosis was in line with experimental findings. The mature macrophage population and its activated subfraction revealed a marked proliferation (IFN-alfa group) during treatment. Growth and activation of macrophages may be compatible with their putative function during erythrocytopoietic regeneration and with stimulation of their phagocytic properties.

Antineoplastic Agents↗
PubMedDate not supplied

Nursing in the People's Republic of China.

In June, 1994 Dr. Grayce Roessler led a group of nurses to China to attend and present at international nursing conferences in Beijing and Shanghai. Dr. Roessler, an internationally known transcultural nursing leader, has traveled extensively in China (some 36 trips over 20 years). Her first trip to China, focused on nursing, took place in the fall of 1981 as a member of the American Nurses Association (ANA). The ANA group was invited to China by the Chinese government and the Chinese Nurses Association (CNA). Subsequent to that visit, she became involved in working with the Chinese Ministry of Health, the Chinese Nurses Association, and several of the CNAs in various cities throughout China. In an effort to assist in the preparation of Chinese nurses as teachers and administrators in the evolving health care system, Dr. Roessler facilitated a one year (1985-86) study program in the United States (Golden West College, Huntington Beach, California) for a group of 20 Chinese nurses. It was the first time in history that a number of Chinese nurses had studied at one institution with American nurses in the United States. Dr. Roessler has since coordinated several international conferences in China and arranged for American nurse experts in various fields to present at these meetings. In addition, she has traveled independently as a teacher and consultant and has taken numerous nursing study tour groups to many countries as part of continuing educational experiences. In this issue of the Journal of Transcultural Nursing, Dr. Roessler presents her reflections on nursing in China from a historical and transcultural nursing leader's perspective.

China↗