Biomedical subjects
Publications and source records attributed to G Rolfini.
The Authors wanted to verify whether neuropeptides like VIP and NPY have a role in regulating the production of PGE2 by the amniotic membrane, by the use of a continuous cell line of amniotic derivation as a model of study. The study was carried out in the laboratories of the 4th Division of the 2nd Institute of the Maternity Home of the Umberto I General Hospital in Rome.
OBJECTIVE: To study the complications related to leiomyomatosis in pregnancy by clinical and ultrasonographic assessment. DESIGN: A retrospective study. SUBJECTS: All pregnancies admitted to the 2nd Institute of Gynecology and Obstetrics, Policlinico Umberto I, in the period between January 1992 to December 1993 were surveyed. RESULTS: Gestational age at the time of ultrasonographic neoplasm diagnosis was 25.1 +/- 13.4 weeks, 'we found no correlation between maternal age or parity affecting pregnancy outcome, Leiomyomatosis complicated pregnancy rate was 1.68%. Myomatosis was diagnosed clinically in 25 of 67 cases (37.3%). Regarding the location of the neoplasm, 59% was located in the corpus-uteri, 21% was considered a diffuse neoplasm and the 14% was located in the fundus. Threatened abortion was the most frequent complication (20%), abortion was the second (16.4%). We observed an increased abortion threat rate (p < 0.001) in those cases where the leiomyoma was in relation with the placenta. We had a surgery rate of 76% in pregnancies complicated by myomatosis, and the indication for surgery was given either primarily or exclusively by the presence of myomatous formation in 19 cases (50%). CONCLUSIONS: Our study suggests that location of the leiomyoma in relation to the placenta is a higher risk factor than its size, and that there is a higher risk for threats of abortion and abortion rates in pregnancies complicated by leiomyomatosis. We recommend that every pregnant woman with a suspected myoma should be ultrasonographically scanned.
The Authors tell about their experience on the use of prostaglandins in patients admitted to the fourth Division of the II Institute of the Maternity Home of the Umberto I General Hospital in Rome, suffering from fetal pathologies not compatible with an autonomous life. They describe the effects of the drugs used, underlying their effectiveness in the induction of therapeutical miscarriage.
Having briefly summarized the physiology of lactogenesis and gactopoiesis, the authors stress the fundamental role played by prolactin. In this context, they suggest medical treatment intended to improve mammary function in cases of deficient lactation. Two different types of treatment were tried: direct administration of prolactin or administration of antidopaminergic drugs capable of increasing endogenous prolactin production. In addition to confirming once more the usefulness of early physiological stimulation by suckling, experience in a group of puerperae showed that treatment apt to increase prolactin serum levels was the best therapeutic choice.
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