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Biomedical subjects

G Roth

Publications and source records attributed to G Roth.

At least 91 records · Page 5Linked to original sources

Tubular device for intraoral examination of rodents.

The device consists of a tube with a conical end, a base, and a movable stem. The rodent is anaesthetized lightly with ether and inserted quickly into the tube so that the head extends beyond the opening at the conical end, where cheeks, upper and lower incisors are secured to permit illumination and direct visual or microscopic examination of the palate, molars or gingiva.

Animals

[Measurement of fluorescent polarisation in the amniotic fluid to assess fetal lung maturity (author's transl)].

A new method for determining fetal lung maturity is discussed. Molecular mobility can be determined spectrophotometrically by measuring the fluorescent polarisation (FP) in lipid solutions. This method of determining the microviscosity in lipid solutions can now be applied also in the amniotic fluid. Measurement of FP by means of an electro-optical microviscosimeter is proportional to the lipid concentration in the amniotic fluid and is in good correlation with fetal lung maturity. FP was measured between the 17th and 41st weeks of gestation in 147 amniotic fluid samples. During pregnancy the FP value drops significantly from 0.350 to 0.200. A FP value of 0.290 was fixed as the limit value beyond which RDS may be expected to occur. With a limit value of 0.290, the RDS identification probability was calculated at 94%, whereas the calculated probability of RDS was 81% and the exclusion probability of RDS 97%. At the same time, the probabilities, calculated on the parallel determination of the L/S ratio, yielded a slightly more unfavourable result. The drop in the FP level correlates significantly with the increase of the L/S ratio in the investigated amniotic fluid samples (correlation coefficient 0.77). The method, which requires very special equipment, offers many advantages: it is very accurate, simple, well reproducible and can be performed within half an hour at relatively low laboratory cost.

Amniotic Fluid

[Propranolol for prophylaxis of migraine (author's transl)].

The prophylactic effectiveness of propranolol (80 to 120 mg per day) in 18 migraine patients was compared with a placebo group of 19 migraine patients in a double blind study without cross over for a treatment period of six and twelve weeks. A statistically significant difference in effect could not be ascertained. The results and methodological assumptions of the double blind studies with cross over already under consideration in the literature are discussed.

Clinical Trials as Topic

Children's drawings about dentistry.

Drawings about the dentist at work were solicited from 1,101 children in grades 2, 4, 6 and 8 in an urban school district. A system to classify the contents of these drawings was developed. The frequency of various items occurring in the children's drawings was determined. The "typical" or most frequent child's drawing of the dentist at work was described. This drawing contained a normal dental chair, dentist, a patient in the chair and dental cabinetry or furniture. The picture was a very matter-of-fact representation. Abnormal or bizarre pictures occurred infrequently. A few children drew pictures that did not relate to dentistry.

Adolescent