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G Roux

Publications and source records attributed to G Roux.

83 records · Page 5Linked to original sources
PubMedDate not supplied

[The urinary elimination of cobalt 57 in iron-deficiency anemia and in iron-overload states].

The authors used the 57 Co urinary excretion test to assess the intestinal absorption of iron in anemia associated with hypoferrinemia and in iron overload states. Among the anemia associated with hypoferrinemia, a high elimination of 57 Co had been found in all patients (15) with post-haemorrhagic iron deficiency anemia. Conversely, this elimination was very low in all 10 patients with anemia due to chronic inflammatory diseases. Moreover the test detected few iron deficiency anemia due to a decreased intestinal absorption of iron. In the iron overload states, the test had been performed in 2 subgroups of patients : chronic anemic patients with transfusional iron overload and hemochromatosis without anemia. In the transfusional iron overload group, 19 patients with thalassemia major who are routinely transfused have a moderate decrease of the 57 Co excretion. This finding probably reflects a continuing intestinal absorption of iron. On the other hand, 6 patients with acquired idiopathic sideroblastic anemia have a very low excretion. In the non anemic hemochromatosis, a high urinary level of 57 Co was present in 5 patients with idiopathic hemochromatosis when it was lower and variable in 6 patients with alcoholic siderosis. Using Wilcoxon, Mann and Whitney's non parametric test, there is a significant difference between the results of both groups. So, in idiopathic hemochromatosis, the high urinary level of 57 Co reflects an inappropriately high absorption of iron in spite of the iron overload and the test may be of value in detecting asymptomatic carriers of the disease.

Adolescent↗
PubMedDate not supplied

[Role of alpha 1 adrenergic receptors in water balance in the rat].

The effects of phenylephrine (alpha 1 +) and prazosin (alpha 1 -) on water intake, diuresis, food intake and blood pressure were compared in conscious normal and diabetic insipidus (DI) Long Evans rats. The two drugs did not change the values measured on 24 hours in the two groups of animals (tables I and II). Phenylephrine induced a diuretic response in both normal and DI rats during the two first hours. Water intake was decreased in normal rats and increased in DI animals (fig. 1). Prazosin induced an antidiuretic effect in the two groups of animals, an increase in water intake in normal rats and a decrease in water intake in DI animals (fig. 2). Blood pressure was not changed in the two groups of animals two hours after injection. The comparison between the different results shows that the first changes induced by phenylephrine or prazosin were changes in diuresis. Since the two drugs act in a same way on the diuresis of normal and vasopressin--deprived rats, it is concluded that the neurohypophysial peptide is not involved in the variations of urinary volume induced by the alpha 1-adrenergic drugs.

Animals↗
PubMedDate not supplied

[Effects of clonidine on diuresis and water intake in normal and Brattleboro rats. (author's transl)].

1. The effects of clonidine on water balance were compared in normal (N.) and diabetes insipidus (Brattleboro D.I.) conscious rats. Animals were housed in individual cages and feed food and water ad libitum. The dose of clonidine was 100 microgram . kg-1 by subcutaneous route during consecutive 9 days. A control period of 12 days without drug treatment (only saline as a sham injection) separated the different period treatments. Under these experimental conditions the values of diuresis, water and food intakes, blood pressure were measured every morning before clonidine-treatment. 2. In normal rats, clonidine induced a diuretic and dipsogenic action (fig. 1). In contrast, the drug elicited an antidipsogenic and antidiuretic response in D.I. rats (fig 2). 3. In another series of experiments, the short term responses to clonidine treatment were studied in the two groups of animals. During the two first hours of treatment, clonidine elicited a rapid and marked reduction in water intake in the two groups of animals (table I). In normal rats, the drug also elicited an increase in urine flow. In contrast, in D.I. (Brattleboro) rats, an antidiuretic effect was observed during the first 30 minutes after clonidine- injection but not during the following 30 minutes periods (fig 3). 4. Clonidine increased both the natriuretic and kaliuretic excretion in normal rats, but failed to modify these values in D.I. rats (fig 4). 5. Clonidine decreased blood pressure in the two groups of animals (table II) but failed to modify the values of food intake (table III). 6. These results suggest that clonidine-induced diuresis is related to inhibition of vasopressin (ADH) secretion. Since the early observation of water balance revealed a clonidine antidipsogenic-induced effect in the two groups of animals, it is suggested that vasopressin was not involved in the clonidine induced water intake and that the daily antidiuretic response in Brattleboro (D.I.) rats was only related to the antidipsogenic property of clonidine.

Animals↗