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Biomedical subjects

G Rozbicka

Publications and source records attributed to G Rozbicka.

9 recordsLinked to original sources
PubMed1984

The role of endogenous opiates in the mechanism of inhibited luteinizing hormone (LH) secretion in women with anorexia nervosa: the effect of naloxone on LH, follicle-stimulating hormone, prolactin, and beta-endorphin secretion.

The aim of this study was to evaluate the role of endogenous opiates in the mechanism of decreased LH secretion in women with anorexia nervosa. For this purpose the effect of opiate receptor blockade with naloxone on LH, FSH, PRL, and beta-endorphins secretion was studied in 24 women with anorexia nervosa and 7 normal women. Serum LH, FSH, PRL, beta-endorphin-like substance, ACTH, and cortisol concentrations were measured before and after opiate receptor blockade after a single iv dose of 0.2 mg/kg naloxone or saline. Mean serum LH and FSH concentrations increased significantly after naloxone in the normal women. Eleven patients had a significant increase in serum LH concentrations in response to naloxone and 13 did not respond to naloxone with an increase in LH concentration. In the first group the basal LH values were higher than those in the second group. In the majority of patients in the first group amenorrhea preceded the wt loss, whereas in most patients in the second group amenorrhea appeared during the phase of wt loss. Naloxone did not alter pulsatile LH secretion in 6 women. No effect of naloxone on serum FSH and PRL concentrations was found. A significant increase in beta-endorphin-like substance levels after naloxone administration occurred in patients with anorexia nervosa. However, serum ACTH and cortisol concentrations were not altered in response to naloxone. In conclusion, the increase in LH release after opiate receptor blockade by naloxone suggests that endogenous opiates may play a role in the mechanism of inhibited LH secretion at least, in the majority of those women with anorexia nervosa in whom amenorrhea preceded wt loss. The results also point to a different mechanism of ACTH and beta-endorphin secretion in patients with anorexia nervosa.

Adolescent↗
PubMed1984

The effect of D-Trp6-LRH upon secretion of gonadotrophin--a possible therapeutic application in anorexia nervosa.

The aim of this study was to evaluate the effect of the agonistic LRH analogue (D-Trp6-LRH) on LH, FSH and prolactin secretion, and its possible efficacy in female patients with anorexia nervosa. The study included 18 female patients with anorexia nervosa and 7 healthy women in the same age group. The patients with anorexia nervosa were divided into two groups of 9 women each. The first group consisted of patients in the weight loss phase of the disorder and the second of 9 women who had achieved normal body weight. Additionally, in 6 women with anorexia nervosa serum LH concentration was determined in response to native LRH before and 14 days after the treatment with D-Trp6-LRH. Serum LH, FSH, prolactin concentrations were determined before and 5, 10, 24 and 48 h after administration of D-Trp6-LRH in a dose of 5 micrograms. The serum LH response to D-Trp6-LRH in the second group did not differ from that of the control group. However, in women with anorexia nervosa in the weight loss phase, LH release in response to administration of the analogue was significantly lower. FSH release after LRH analogue administration in both groups of patients with anorexia nervosa did not differ from that in the control group. The increased LH secretion in response to native LRH after treatment indicates that D-Trp6-LRH in low doses did not inhibit pituitary responsiveness. A dose of 5 micrograms of D-Trp6-LRH was administered in a therapeutic regimen every 48 h from 1 to 3 months to 7 of 9 patients with anorexia nervosa who exhibited amenorrhoea in spite of normalization of body weight.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1983

Enhanced serum prolactin concentration after metoclopramide stimulation in idiopathic oligozoospermia and azoospermia.

The aim of the study was to evaluate the hormonal pattern in men with idiopathic oligozoospermia and azoospermia. Material consisted of 13 sterile men, 21-34 years old (the mean - 27 years). Three of 13 patients had the third degree oligozoospermia, 3 - extreme oligozoospermia and 7 - azoospermia. The control group consisted of 11 healthy men who were found to have normozoospermia. In all patients and in control subjects the estimation of LH, FSH, prolactin (PRL), testosterone and dihydrotestosterone (DHT) in basal conditions and also PRL determination at 15, 30, 60 min after stimulation with metoclopramide (MCP 10 mg i.v.) were performed by radioimmunoassay. The results indicate that men with idiopathic oligo- or azoospermia have significantly higher prolactin level in response to dopaminergic receptor blockade with metoclopramide and significantly lower serum testosterone and DHT concentrations.

Adult↗
PubMed1983

[Interdependence between hormonal disorders, staging and degree of malignancy of prostatic gland cancer. 2].

The aim of this study was to estimate the relations between oestrogen, progesterone, prolactin (PRL) and gonadotrophin levels and the degree of advancement as well as that of malignancy of carcinoma of the prostate. Serum LH and FSH levels were determined under baseline conditions and after stimulation with LH-RH. In patients with metastases and in less differentiated forms of carcinoma the level of oestradiol (E2) was significantly higher. The testosterone/oestradiol ratio was notably lower in patients without metastases and in more differentiated forms. Serum progesterone was significantly higher in less differentiated forms of carcinoma. The concentration of LH in response to the administration of LH-RH was significantly higher in patients with metastases. Measurement of hormone levels at certain stages in the course of carcinoma of the prostate may be of practical value in the choice of appropriate hormone treatment.

Aged↗