PubMed Health⌕ Search

Biomedical subjects

G S Beagrie

Publications and source records attributed to G S Beagrie.

At least 19 recordsLinked to original sources
PubMed1994

The effects of spiramycin and/or scaling on advanced periodontitis in humans.

It has long been questioned whether antibiotics, used as a supplement to traditional therapy, provide any lasting benefit in the treatment of chronic periodontitis. This study was designed to evaluate Spiramycin as an adjunct to scaling and root planing in the treatment of advanced chronic periodontitis. In total, 193 patients with advanced periodontitis were recruited in seven centres using selection criteria previously described. After undergoing thorough scaling and root planing, all patients randomly received either Spiramycin, 1,500,000 international units, twice per day (IU, bid) for 14 days (96 patients), or a visually-identical placebo capsule (97 patients). The clinical parameters measured were plaque index, crevicular fluid level, probing depths, bleeding on probing and attachment level changes. Data was recorded at baseline, two-, eight-, 12- and 24-weeks visits. A total of 189 patients completed the study (96 placebo, 93 Spiramycin). Statistically significant differences in probing depth, favoring Spiramycin, were seen at two weeks (p < 0.0125), eight weeks (p < 0.0020), 12 weeks (p < 0.0032) and 24 weeks (p < 0.0075). Spiramycin also produced a significant improvement in attachment level at 12 weeks (p < 0.0146). All other clinical parameters showed no difference between drug and placebo. This study shows that Spiramycin, as an adjunct to thorough scaling and root planing, provides a statistically significant improvement in probing depths for up to 24 weeks when compared with scaling and root planing alone. Both longer studies and microbiologic evaluations are necessary to determine whether a more lasting benefit is possible.

Adult↗
PubMed1988

The responsibilities and role of universities in dental manpower.

Although other educational facilities are needed for developing the oral health manpower team, universities have the primary role in educating the dentist. The need for a curriculum based on fundamental research which is responsive to the needs of society is essential for the future development of the profession. Oral health manpower plans should be dependent upon the type of service designed for a country and an appropriate mix of manpower should be developed. By the collection, monitoring and interpretation of epidemiological data, universities have a major role to play in the forecasting of trends. Relevance of programmes within universities in health matters must be made more apparent to the community, especially when financial restriction in both health services and higher education are being felt. A national planning programme, centrally managed to include national associations, government, universities and interested parties, is essential if the relevance of oral health manpower is to be maintained.

Canada↗
PubMed1980

Oral disease prevention--its implications and applications: summary of proceedings.

It would seem that "tried favorites" are currently the preferred application methods, not that the futuristic technology is unimportant. Pragmatism must prevail, however, and simple self-care, associated with high quality organization, is the order of today. Isolation and treatment of risk groups will become common courses and test methods of Brathall and others will come into their own. Immunization, laser beam treatment, and other sophisticated methods will develop and future conferences will probably hear of their use. It would appear pertinent, because of the importance of oral health promotion, to recognize the weaknesses shown in that area and suggest a research conference to examine the subject of oral health education of the dentist and the public. Could this be the subject for the Ninth conference?

Dental Care↗
PubMed1979

Clinical evaluation of spiramycin and erythromycin in control of periodontal disease.

Two studies are reported. Each was double-blind in which Spiramycin was compared to Erythromycin and a placebo, to determine the value of Spiramycin as a therapeutic agent in the control of periodontal disease. In Study 1, 48 adults with varying degrees of periodontal disease were randomly assigned to treatment and control groups. Assessments of gingival index, plaque height, pocket depth, crevicular fluid volume and wet plaque weight were made. During this 4-week clinical trial, the patients maintained their usual oral hygiene. The medication was administered systemically for 5 days, starting at the conclusion of week 2. Spiramycin significantly reduced the scores for the five parameters recorded. When comparison were made, the greatest recorded effect with Spiramycin treatment was found in patients with advanced periodontal disease. The indication of this trend favouring Spiramycin led to an extension of this clinical trial involving only patients with advanced periodontal lesions. This second study comprised 54 adults. The same parameters were measured over the same time period as in Study 1. Spiramycin again was responsible for the greatest reduction in the recorded scores. For example, average pocket depth was decreased by approximately 30%, whereas Erythromycin produced a reduction of 15%. It would appear that Spiramycin is of definite benefit in the management of periodontal disease, especially in the more advanced cases.

Administration, Oral↗
PubMed1979

Effect of two antibacterial mouth sprays and dentifrices on dental plaque and gingivitis in beagle dogs.

Plaque inhibition by dilute mouth sprays and dentrifrices containing benzethonium chloride and chlorhexidine gluconate was compared in beagle dogs. Agents with chlorhexidine gluconate produced less plaque than their benzethonium chloride or placebo counterparts, but the differences were not significant when compared to mean control scores registered during interexperimental recovery periods.

Aerosols↗
PubMed1978

Profiles.

Explore the source record for details and available documents.

Australia↗
PubMed1977

Strength determination of periodontal splints fabricated from acid-etched retained materials.

Six systems (one polycarboxylate, one polymethyl methacrylate, one unfilled BIS-GMA resin, two combinations of methyl cyanoacrylate and polymethyl methacrylate, and one combination of unfilled BIS-GMA and filled composite resin) were evaluated for in vitro retention to acid-etched human enamel. Also tested were one unfilled-filled resin combination backed by perforated orthodontic band metal and another unfilled resin backed by stainless steel wire mesh. Significant differences in retention were found. Results show that retention depends pril surface and to resist subsequent chemical degradation.

Acid Etching, Dental↗
PubMed1975

Investigation of possible oncogenic action of zinc polycarboxylate cement by implantation in mice and hamsters.

Powdered, sterilized zinc polycarboxylate was implanted subcutaneously in 56 young hamsters and 54 mice, using equal numbers of each sex, with 24 sham operated hamsters and 26 mice as controls. The hamsters were sacrificed after 15 months and the mice after 12. Implant material was recovered from one of 42 surviving mice and from 16 of 43 surviving hamsters. Benign adenomas of the gut, thyroid, sebaceous glands and ovary were found in 3 experimental mice and in one control. Benign adrenal adenomas were found in 3 experimental hamsters and in one control. One control hamster developed a rhabdomyosarcoma in a limb. One experimental hamster developed a leiomysarcoma in close relation to an implant.

Acrylates↗