PubMed Health⌕ Search

Biomedical subjects

G S Bhatia

Publications and source records attributed to G S Bhatia.

9 recordsLinked to original sources
PubMed2001

Patterns of use of unconventional therapies in the medical outpatient department of a tertiary care hospital in India.

Unconventional, alternative or unorthodox systems of treatment have become increasingly popular in recent years. We interviewed patients visiting the Internal Medicine outpatient department (OPD) for a period of 6 months regarding their use of unconventional therapies. Overall 76% of patients visiting the OPD had used one or more of the unconventional therapies in the past 1 year. Homeopathy was found to be the most frequently used alternative therapy (38.6%). A large number of patients used more than one unconventional therapy. Digestive problems, backache, joint pains and bronchial asthma were the most frequent conditions for which alternative therapies were used. Most patients who used alternative therapies used them on their own, without actually visiting a provider of such therapies. Because of the widespread use of alternative systems of medicine, efforts to enhance understanding about these forms of treatment have to be made.

Adolescent↗
PubMed2000

Control of olefin geometry in the bryostatin B-ring through exploitation of a C(2)-symmetry breaking tactic and a Smith-Tietze coupling reaction.

A completely stereocontrolled asymmetric synthesis of an advanced B-ring synthon for the bryostatin family of antitumor agents is reported. Noteworthy features of our synthesis include the Smith-Tietze bis-alkylation reaction between 12 and 13 en route to C(2)-symmetrical ketone 10 and the totally stereoselective conversion of 10 into triol 18 via a Grignard addition tactic. Triol 18 was converted to epoxide 3 in nine steps, and an acid-catalyzed intramolecular Williamson etherification reaction completed the synthesis of 2.

Alkenes↗
PubMed1990

Chronic toxicity of styrene maleic anhydride, a male contraceptive, in rhesus monkeys (Macaca mulatta).

A newly developed male contraceptive, styrene maleic anhydride (SMA), was injected in the vas deferens of male rhesus monkeys for safety evaluation at the dose of 100 mg (contraceptive dose, CD), 250 mg (CD x 2.5) and 500 mg (CD x 5.0), and the monkeys were kept under observation for one year. The observed behavioural, haematological, biochemical and histopathological parameters in treated monkeys were comparable to controls. The results suggest the polymer SMA to be safe up to 5 times CD in monkeys.

Adrenal Glands↗
PubMed1985

Effect of epinephrine and norepinephrine on immuno-reactive insulin secretion from isolated islets of Langerhans.

Earlier studies have demonstrated the inhibitory nature of epinephrine and norepinephrine on pancreatic insulin release. The present study reports their effect on beta-cell IRI release in an isolated islet system. Results show that epinephrine and norepinephrine inhibit islet-IRI release at the 100-10 microM level. The alpha adrenergic blocker phentolamine (100 microM) but not the beta adrenergic blocker propranolol (100 microM) can reverse this catecholamine induced inhibition of islet-IRI release. This clearly suggests that epinephrine and norepinephrine inhibit insulin release via alpha-adrenergic pathway.

Animals↗