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Biomedical subjects

G S Blair

Publications and source records attributed to G S Blair.

10 recordsLinked to original sources
PubMed1991

The biochemical and haemodynamic effects of adrenaline in lignocaine local anaesthetic solutions in patients having third molar surgery under general anaesthesia.

The effects of adrenaline-containing and adrenaline-free lignocaine local anaesthetic solutions injected in doses consistent with clinical practice on plasma potassium concentration, blood glucose levels and haemodynamic responses were investigated in 20 patients having third molar surgery under general anaesthesia. All patients received a standard general anaesthetic regime. Ten patients were given 4.0 ml of 2% lignocaine as an inferior dental and long buccal block during their general anaesthetic and the other 10 received 4.0 ml of 2% lignocaine containing 1:80000 adrenaline in the same manner. There were no significant differences between treatments in blood pressure or heart rate. However, there were significant differences between treatments in plasma potassium concentration and blood glucose levels.

Adult↗
PubMed1991

Primary Sjögren's syndrome in north east England--a longitudinal study.

We have documented the initial clinical features of 100 patients with primary Sjögren's syndrome (SS) together with the results of their baseline investigations. The evolution of the disease in these patients has been followed for a median of 34 months (range 3-84 months). The majority of patients were females aged 40-60 years, and common clinical features included eye symptoms (100%), xerostomia (100%), polyarthralgia (94%), Raynaud's phenomenon (81%) and salivary gland swelling (47%). Thyroid disease was relatively common (14%) while other endocrine disease was rare. Four patients died during follow-up, and three cases of lymphoma were detected. Other serious complications included pericarditis (10%), pleuroparenchymal lung disease (9%), renal tubular acidosis (3%) and cerebrovascular accidents (2%). The presence of anti-Ro antibodies identifies patients with more severe systemic disease. Spontaneous improvement occurred in 12 patients, while steroids were required for specific complications in 18. Overall, although lymphoma was found to excess in our group, the high mortality reported with primary SS elsewhere was not seen.

Adolescent↗
PubMed1975

Screening in a dental clinic for adult rheumatoid arthritis involving the temporomandibular joint using a statistical discriminant function.

The radiological features seen on the temporomandibular joint radiographs of ninety-nine cases of adult rheumatoid arthritis were used to distinguish this group from a group of eighty-three control subjects using the method of logistic discrimination. A readily calculable diagnostic score, whose value was verified by a second study involving thirty-two patients, sixteen of whom suffered from adult rheumatoid arthritis, was estimated. This second study was further used to illustrate how this scoring system would be modified to take account of extra information. Although a long term evaluation of the method is envisaged its clinical application is indicated and its practical value demonstrated.

Adolescent↗