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Biomedical subjects

G S Brody

Publications and source records attributed to G S Brody.

At least 19 recordsLinked to original sources

Augmentation mammaplasty and breast cancer: a 5-year update of the Los Angeles study.

We have previously reported on the risk of breast cancer in women during the first few years following cosmetic augmentation mammaplasty and are now presenting results after longer exposure. Long-term carcinogenicity of breast implants in humans has not been assessed previously. We conducted a retrospective cohort study of 3112 patients with a median of 10.6 years of postimplant experience (range 0.1 to 31.7 years). Patients were enrolled from surgeons' records, and cancer outcomes were monitored by the population-based cancer registry serving Los Angeles County. Because of confidentiality concerns, there was no direct patient contact. Twenty-one breast cancers were observed among the implant patients as compared with 31.7 expected, based on Los Angeles County incidence rates [standardized incidence ratio (SIR) = 66 percent, 95 percent confidence limits (CL): 41 percent, 101 percent]. For all other malignancies combined, 45 were observed and 50.0 were expected (SIR = 90 percent, CL: 66 percent, 120 percent). Although the numbers of cases were very small, increased frequencies of lung and vulvar cancers were observed. Based on the evidence to date, we conclude that there is no increase in breast cancer incidence following augmentation mammaplasty.

Breast Neoplasms

Reflex sympathetic dystrophy syndrome: consensus report of an ad hoc committee of the American Association for Hand Surgery on the definition of reflex sympathetic dystrophy syndrome.

This report proposes that reflex sympathetic dystrophy be defined as a pain syndrome in which the pain is accompanied by loss of function and evidence of autonomic dysfunction. In the clinical setting, this diagnosis is usually associated with other anatomic and psychological diagnoses and may be associated with a variety of systemic illnesses and medicolegal factors. All components should be assessed before a treatment plan is established. Priorities should go to emergency care, acute injuries, and systemic illness, psychiatric problems, and chronic anatomic problems, in that order. Early, accurate diagnosis improves prognosis.

Consensus Statements as Topic

Silicone technology for the plastic surgeon.

There is a considerable misconception regarding the properties of silicone gels and envelopes among plastic surgeons. This is partly due to the counterintuitive characteristics of this unique material. The material is relatively weak as rubbers go, its deformation characteristics are time-related, and its permeability varies with the substance involved. Closed capsular rupture should be performed with caution; current prostheses are not designed as a drug delivery system and should never be used as such.

Breast

Secondary correction of the burned eyelid deformity.

We describe our experience in late reconstructions of 35 burned eyelids. On this basis we advocate wide, aggressive release of all scar contractures, including the distal part of the levator when necessary. To cover the resultant defects we use generous full-thickness skin grafts, if available, for both the upper and lower lids. Rarely has a tarsorrhaphy been required, and properly constructed dressings provide satisfactory lid immobilization and permit conjunctival hygiene. During the postoperative period the vision need not be obstructed by a tarsorrhaphy, Frost sutures, or the dressings.

Adult

Surgical correction of burn deformities of the nose.

We present a method for reconstruction of the everted nostrils of the burned nose. Through a "ram's horn" incision, the everted vestibular lining and lower lateral cartilages are mobilized and repositioned, and the resultant defect is covered with a full-thickness skin graft. The linear scar is created as part of a circle, so that the postoperative contracture will improve the alar contour.

Burns

Rapid application of skin grafts.

We describe the use of modern surgical staplers and clips to permit the rapid application of skin grafts over large and complex defects. This saves anesthesia time, permitting more extensive surgery. "Skin tunnels" are virtually eliminated.

Humans

The surgical treatment of drooling. A ten-year review.

We report a 10-year experience with 123 patients who had the surgical treatment for drooling originally described by Wilkie. All have been followed for at least 1.5 years, and in 86 percent a good or excellent result was obtained. We believe this procedure is indicated for persistent, severe drooling in any patient in whom non-operative methods have failed, and for whom general anesthesia is an acceptable risk. Severe intellectual impairment is not a contraindication, for the care of these patients may be made far easier. Bilateral removal of the submandibular glands is an integral part of the operation on all patients, and should be done at the same time the parotid ducts are rerouted. The complications have been few and most of them respond to secondary procedures.

Cysts