Cellular proliferation and secretion in the adenohypophysis of diethylstilbestrol-treated rats.
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Animals↗
Biomedical subjects
G S Delides
Publications and source records attributed to G S Delides.
Latent carcinoma of the prostate: the probability of identifying small lesions in routine histology.
In 3,072 open prostatectomy specimens covering a 25-year period 117 (4%) showed frank carcinoma. A further 74 cases showed areas of occult carcinoma or atypical hyperplasia. These focal lesions had an average diameter of 1 mm and 96% were situated in the peripheral regions of the specimen. In view of the situation of these lesions and their small size, an improved method of taking blocks for histological sections from prostatectomy specimens is proposed, resulting in an increased probability of demonstrating the areas of occult malignancy.
Carcinoma↗
Bone and cartilage in malignant tumours of the urinary bladder.
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Adenocarcinoma↗
Megacloaca in an asexual stillborn.
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Abnormalities, Multiple↗
P53 expression in patients with malignant and benign breast diseases.
Immunohistochemical expression of p53 protein was studied in FNA specimens of 20 breast ductal carcinomas, 20 fibroadenomas and 20 atypical ductal hyperplasia of the breast. Nine cases of breast carcinomas (45%), five fibroadenomas (25%) and four atypical ductal hyperplasia (20%) were found to be p53-immuno-positive. A statistically significant difference was found among p53 staining index of breast carcinomas (mean 72.55%), fibroadenomas (mean 41.2%) and atypical ductal hyperplasia (mean 34%). Variations in p53 expression among individual breast carcinomas was found, and these variations may correlate with prognosis.
Biopsy, Needle↗
Cytological diagnosis of malignant mixed müllerian tumor of the uterus in ascitic fluid.
The malignant mixed Mullerian tumour (MMMT) is a rare and aggressive neoplasm of the uterus, seen in postmenopausal women. In this case, an uncommon neoplasm was diagnosed cytologically in the ascitic fluid of a woman 58 years old and was confirmed histologically after hysterectomy and bilateral adnexectomy.
Ascitic Fluid↗
Bcl-2 expression as an apoptotic index in non small cell lung carcinomas.
To evaluate the bcl-2 protein expression in non small cell lung carcinomas (NSCLC) as an index of apoptosis of these tumors, in fine needle aspiration biopsies (FNABs) of the lung, we studied thirty-eight cases of NSCLC (25 bronchogenic adenocarcinomas and 13 squamous. carcinomas. Bcl-2 protein was used as the primary antibody (monoclonal, DAKO) by Alkaline-phosphatase method. Very light haematoxylin was performed as the counterstain. The results were compared and confirmed histologically. A cytoplasmatic expression of the bcl-2 protein was found in 72% (18 out of 15) of the bronchogenic adenocarcinomas while 61.54% (8 out of 13) of squamous carcinomas showed bcl-2 expression. For the quantitative analysis of our results, we used the t-test and the difference between those two histologic types was regarded as statistically significant with p < 0.001.
Adenocarcinoma↗
Cell proliferation and DNA fragmentation (apoptosis) on FNABs of breast invasive ductal carcinomas and their relationship to clinicopathological variables and prognosis.
The purpose of this study was to investigate cell proliferation and apoptosis in ductal breast invasive carcinomas and their relationship to prognosis. Fifty cases, from the same number of operable female patients, were diagnosed cytologically on FNA biopsies as invasive ductal breast carcinomas and confirmed histologically after oncectomy. In the same cases, to evaluate the cell proliferation and apoptosis, the MIB1 and the TUNEL method were used respectively. Furthermore the relationship between proliferative activity and apoptosis to other factors such as menopausal status, tumor size, axillary lymph node status and tumor grade was studied. Cell proliferation and apoptosis were found to be significantly related to the menopausal status of the patients (p < 0.001) and to the grade of the tumor (p < 0.01), while no significant relationship to axillary lymph node status and tumor size was found.
Adult↗
HSP-70, C-myc and HLA-DR expression in patients with cutaneous malignant melanoma metastatic in lymph nodes.
HSP-70, C-myc and HLA-DR were examined in patients with cutaneous malignant melanoma metastatic to lymph nodes. Lymph-nodal fine-needle aspiration biopsies (FNABs) were analyzed and the results were correlated to other variables, such as the gender of the patients, Clark level and Breslow thickness of the primary tumor. Thirty cases of metastatic melanoma in lymph nodes from 30 patients with cutaneous malignant melanoma were studied. All patients (100%) had microscopic regional nodal metastasis and a recurrence of the lesion during the first two years. The HSP-70, C-myc and HLA-DR expressions were investigated immunocytologically, using the APAAP (alkaline phosphatase) method on the FNAB samples. The immunocytochemical expressions of HSP-70 protein, C-myc oncogene, and HLA-DR antigen were found in 18 cases (60%), in 14 cases (43.3%) and in 12 cases (40%), respectively. Clark levels were significantly associated with HSP-70 protein (< 0.01), C-myc oncogene expression (< 0.05) and HLA-DR antigen (< 0.01) expression. The HLA-DR antigen was also found to be related (< 0.05) to higher Breslow thickness (> 1.5 mm). The clinical course of malignant cutaneous melanoma is related to the expression of these indices, which seem to play a significant role in the metastasis and prognosis of this aggressive tumor. The immunocytochemical expression of HSP-70 in the malignant melanoma tumor could be of particular value in the identification of patients with poor prognosis.
Biomarkers, Tumor↗
Gliosarcoma cerebri with a myxoid matrix of the sarcomatous component.
A case of a cerebral gliosarcoma in a 63-year old female located in the left parietooccipital area of the brain is herewith described. Histology showed the tumour to consist of two components: a gliomatous resembling glioblastoma, and a sarcomatous with a prominent myxoid intercellular substance, a feature reported only thrice before in the medical literature. We report the histochemical and immunohistochemical characteristics of our case, and compare them with those of previous case reports.
Brain Neoplasms↗