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Biomedical subjects

G S Freedman

Publications and source records attributed to G S Freedman.

At least 19 recordsLinked to original sources
PubMed1977

The anatomic splenic flexure: an ultrasonic renal impostor.

The anatomic splenic flexure of the colon occupies the left renal fossa in patients with agensis or ectopic of the left kidney. On ultrasonic scans, the colon filled with stool or fluid may simulate a kidney or mass. This mass is often comma shaped on the transverse scans and lacks good definition of its inferior margin on longitudinal scans. An evaluation of a patient with only right renal function should combine radiologic techniques with ultrasonography to establish the correct diagnosis.

Adolescent↗
PubMed1976

Radionuclide angiography.

Radionuclide angiography is an established, widely used diagnostic tool. It is safe, easy to perform, and the low patient radiation dose makes frequent follow-up studies feasible. High-quality scintiscans have contributed to the widespread clinical acceptance of the procedure. The areas of application include virtually every organ of the body. In the brain, abnormalities in cerebral perfusion may be detected with this technique. Hepatic and renal tumors can be differentiated from cysts with radionuclide angiography. Its application to cardiology is achieving rapid growth and acceptance in both congenital and acquired heart disease.

Aortic Diseases↗
PubMed1976

Dual radionuclide study of myocardial infarction. Relationships between myocardial uptake of potassium-43, technetium-99m stannous pyrophosphate, regional myocardial blood flow and creatine phosphokinase depletion.

The dual radionuclide myocardial distributions of imaging agents potassium-43 (43K) and technetium-99m stannous pyrophosphate (99mTc-PYP) were studied in a 24-hour closed chest canine infarct preparation. In multiple myocardial biopsies in 20 dogs, tissue levels of both radionuclides were compared to either an index of tissue viability (myocardial creatine phosphokinase [CPK] depletion), or to estimates of regional myocardial blood flow as measured by the microsphere technique. Myocardial 43K uptake in the ischemic and infarcted zone correlated well with both CPK depletion (r = 0.73) and microsphere estimates of relative blood flow. The correlation with microspheres was excellent in the transmural sample (r = 0.93) as well as endocardial (r = 0.97) and epicardial (r = 0.86) portions. On the other hand, 99mTc-PYP myocardial uptake did not correlate with the extent of CPK depletion. Maximal uptake was frequently noted in border zones with only moderate CPK depletion, while lesser degrees of 99mTc-PYP uptake were noted in the central infarct zone where CPK activity was lowest. The relationship of 99mTc-PYP uptake to microsphere regional flow estimates demonstrated that 99mTc-PYP uptake was maximal at flows of 0.3 to 0.4 of normal. At lower flows, 99mTc-PYP uptake fell toward normal levels. A similar relationship was noted between the distributions of 99mTc-PYP and 43K. In relatively high flow border segments (larger than or equal to 0.80 of normal), abnormal 99mTc-PYP uptake of five to six times normal persisted. The transmural distribution of 99mTc-PYP demonstrated that in low flow regions 99mTc-PYP uptake was primarily epicardial, while in the higher flow ischemic periphery of the infarct endocardial uptake predominated. Thus, while there is a direct correlation between cationic 43K myocardial uptake and regional myocardial viability and blood flow, no such direct relationship exists for 99mTc-PYP. This is in part based on the necessity for delivery of the radioactive tracer to the infarct zone.

Animals↗
PubMed1976

Myocsrdial uptake of technetium-99m stannous pyrophosphate following direct current transthoracic countershock.

The effect of direct current (DC) countershock upon myocardial technetium-99m stannous pyrophosphate (PYP) uptake was studied in 22 dogs. All eight dogs imaged had positive abnormal PYP scintigrams that were usually indistinguishable from experimental infarction. In three animals, additional areas of radionuclide uptake were seen in overlying noncardiac tissue. Left and right ventricular myocardial PYP uptake averaged (+/- SEM) 23 +/- 5 times control and 24 +/- 6 times control, respectively. These activity ratios occurred without reduction in regional myocardial blood flow (RMBF), and were associated with histologic evidence of necrosis. The necrosis was usually epicardial, corresponding to the transmural site of greatest PYP uptake. The magnitude of PYP accumulation and the weight of damaged tissue increased with increasing applied energy. Thus, PYP uptake following DC countershock could result in false-positive interpretation of acute ischemic myocardial infarction. Since RMBF is normal in regions of PYP uptake, the major determinant of radionuclide accumulation is the extent of cellular damage.

Animals↗
PubMed1976

Radionuclide determination of cardiac chamber flow/volume characteristics.

The flow/volume characteristics of an externally monitored radionuclide dilution curve may contain valuable information about specific cardiac chamber abnormalities. a simplified method of obtaining this flow/volume ratio on a standard scintillation camera is presented. Preliminary clinical application to right-sided cardiac lesions has been undertaken. The implications of flow/volume variation with time are discussed.

Cardiac Volume↗
PubMed1975

The temporal and pathological significance of perfusion failure following renal transplantation.

Serial dynamic studies with 99mTc-DTPA are a useful method of monitoring renal transplants. Radionuclide images obtained within 24 hours after surgery and at regular intervals thereafter can identify pathological conditions. The decline or absence of perfusion, coupled with the elapsed time following surgery, can be used to differentiate vascular occlusion or hyperacute rejection from acute rejection, acute tubular necrosis, or accelerated or chronic rejection. 99mTc-pyrophosphate can be used to simultaneously evaluate transplant function and locate possible aseptic necrosis of bone. Both studies are noninvasive and have been performed safely on numerous occasions over a period of several years.

Angiography↗
PubMed1975

Quantitative relationships between potassium-43 imaging and left ventricular cineangiography following myocardial infarction in man.

To evaluate the quantitative relationships between resting potassium-43 (43K) myocardial imaging and left ventricular segmental contraction abnormalities, 15 patients were studied by both radionuclide and contrast angiographic techniques at least two months following transmural myocardial infarction. The ECG location of infarction involved the anterior wall alone in six patients, inferior wall alone in three patients, both anterior and inferior walls in five patients, and in one patient ECG-anatomic correlation was obscured by newly developed left bundle branch block. 43K defects were noted in all patients. Anterior wall 43K defects were noted in all patients with previous anterior infarction and seven of nine inferior infarcts. These 43K defects were associated with a quantifiable decrease in regional radioactivity of at least 20% of normal appearing zones, and their location correlated with the angiographic site of akinesis or dyskinesis. The extent of the 43K defect (% 43K HP [% potassium 43 hypoperfusion]) was measured by planimetry and averaged 49% of the anterior view image (range 25-66%), 43% of the left anterior oblique image (range 0-58%), with the mean of both views being 47% (range 17-62%). The mean total area of the anterior image was 58 cm2 (range 40-101 cm2). The extent of the 43K defect (% 43K HP) was related to the extent of segmental contraction abnormality (% ACS). Correlations between % ACS and anterior view % 43K HP (r = 0.67), left anterior oblique % 43K HP (r = 0.54), and mean % 43K HP (r = 0.77) were found. The total size of the anterior view image correlated with left ventricular end-diastolic volume (r = 0.79). Thus, in this initial group of patients following transmural infarction, potassium-43 imaging can be accurately and quantitatively correlated with the site and extent of regional ventricular dysfunction as it is assessed by quantitative left ventricular angiography.

Acute Disease↗
PubMed1975

Critical review of tomography in radiology and nuclear medicine.

This review covers conventional radiographic tomography, radioisotopic tomography, and a review of computerized transaxial tomography. Simple, reproducible radiographic tomographic methods are increasing in use, and despite their complexity, the diagnostic results are superior to conventional radiographs. There are many different motions of the X-ray tube and the film which can be employed to create a tomogram. The perfect tomographic motion is partly determined by the geometric shape of the object to be imaged and the thickness of the plane of interest. The undirectional tomographic method blurs a point in a linear fashion; the pleuridirectional method blurs a point over a wider surface. Among the most popular directions used are linear, circular, elliptical, and hypocycloidal. The numerous applications of tomography described in this review are an encouraging, broad-based foundation from which the most clinically useful and economically feasible devices will emerge.

Adrenal Gland Neoplasms↗