Cerebral embolus as a complication of streptokinase therapy.
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Biomedical subjects
Publications and source records attributed to G S Makin.
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A case is presented of isolated pancreatic transection sustained in the course of a game of Association Football. The difficulty of early diagnosis is discussed. Emphasis is laid on the importance of possible pancreatic injury in the normotensive patient and on inspecting the posterior abdominal structures on opening the lesser sac during laparotomy.
The 5 year results using polytetrafluoroethylene (PTFE-Gore-Tex) grafts mainly for superficial femoral occlusion have been reviewed. The majority of these grafts were inserted in an elderly poor risk group of patients with critical ischaemia of the lower limb. The overall cumulative patency at 2 years was 29% falling to 18% at 5 years. Further analyses were performed to take into account risk factors, namely, patient's age, diabetes, hypertension, continuation of smoking, peroperative angiographic findings and the site of the distal graft anastomosis. Peroperative angiographic run off was found to be the only risk factor significantly affecting the cumulative graft patency. The presence of diabetes was found to have a significant detrimental effect on limb salvage.
Twenty-nine patients with peripheral vascular disease had the popliteal artery segment assessed by xeroangiography and nuclear magnetic resonance (NMR) scanning. The result of each test was compared with conventional contrast arteriography. Nuclear magnetic resonance and xeroangiography correctly predicted popliteal artery patency in 97% and 100% of limbs, respectively, and occlusion was correctly predicted in 44% and 63% of limbs. The ability of xeroangiography to define the state of the popliteal artery accurately makes this a useful method in high-risk patients. The potential for NMR imaging appears very promising but more work is required to define its future clinical application.
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A 10 year survey of patients undergoing surgery for abdominal aortic aneurysms is presented. If it is possible to use a straight graft, the postoperative 30 day mortality and morbidity is lower.
The natural history of abdominal aortic aneurysm (AAA) is death from rupture unless the patient dies from another cause prior to rupture. Elective aortic grafting is the treatment of choice. Following rupture, emergency operation is the only treatment which will prolong the patient's survival. Controversy still exists as to the optimum management in poor risk patients and in those with a small aneurysm. This paper describes the presentation and natural history of 65 patients presenting with a ruptured abdominal aortic aneurysm who did not have an emergency operation, and a further 27 patients in whom the diagnosis of intact AAA was made who did not have an elective aortic replacement graft. The correct diagnosis was made at the time of admission in only 43 of the 65 patients with ruptured aneurysms. The diagnostic errors and appropriate investigations in cases of doubt are discussed. The mean time from admission to hospital to death was 8 hours. The reasons for not performing an elective operation in the 27 patients known to have AAA are given. Nine have subsequently died from rupture. There have been 7 deaths from other causes.
A modified technique for performing the Gritti-Stokes amputation is described and the results obtained in 247 cases are presented. The mortality rate was 9.3% and healing occurred in 87% of survivors. Using this modified technique the frequently cited criticisms of non-union of the patella and painful stumps were not found to be major problems. The prosthetic problems of amputation at this level are discussed in relation to recent developments in the design of artificial limbs.
Eight cases of injury to the subclavian and axillary arteries are described. All were accompanied by injury to the brachial plexus. Arterial continuity was restored in all cases. Six young patients sustained high velocity injuries and they showed no neurological improvement. Two elderly patients with low velocity injuries recovered neurological function in the limb. Primary amputation should be considered when nerve damage is obviously very severe.
Fourteen patients with atherosclerotic aneurysms of the popliteal artery, which were bilateral in 13, have been managed in a vascular unit where ultrasound, xerography, and isotope angiography are available for investigation. Although these methods are useful in confirming a suspected diagnosis, they cannot replace an awareness of the condition and clinical methods of examining the ischaemic lower limb. Reconstructive vascular surgery was effective in preserving the presenting leg in 5 cases and amputation was needed in 6, while no operation was needed in 3. Elective arterial surgery was carried out on the asymptomatic contralateral leg in 7 cases with good results and this active approach to treatment is recommended.
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One hundred and eighty-three consecutive operations for ischemia of the lower limb were performed to restore an absent femoral pulse. Ninety-seven patients considered to be fit had an aortofemoral or iliofemoral bypass graft and 86 high risk patients had a femorofemoral or axillofemoral graft. The best results were obtained in those with the aortofemoral or iliofemoral grafts, but superficial grafts were a satisfactory alternative even in the unfit patients with critical ischemia.
Compression bandages are normally applied for 6 weeks after sclerotherapy. The changes in pressure exerted by such bandages have been measured over 8 h. The results show that different surgeons applied bandages over a wide range of pressures but the range for each individual surgeon was surprisingly narrow. The pressure falls with time and approaches zero at 6--8 h of normal activity by the subject, but more slowly if the knee and ankle joints are excluded from the bandage. The initial pressures were higher when STD compression pads were used, although the rate at which the pressure fell was the same.
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The results of 134 Gritti-Stokes amputations for ischaemia are presented. The mortality rate was 11% and healing occurred in 88%, reaffirming the good results already reported for this operation. The long term results are reviewed in an attempt to decide whether the most frequently cited criticisms of this procedure are justified. Stump pain and mobility of the patella were not major problems. The difficulties in fitting a suitable prosthesis are discussed and attention is drawn to the advantages of a new prosthesis that has been developed for this amputation.
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