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Biomedical subjects

G S Martinez

Publications and source records attributed to G S Martinez.

5 recordsLinked to original sources
PubMed2001

Radioimmunotherapy with (111)In/(90)Y-2IT-BAD-m170 for metastatic prostate cancer.

PURPOSE: Over 31,000 Americans die of androgen-independent metastatic prostate cancer each year. New strategies that do not involve hormonal manipulation but instead recognize the biochemical and molecular characteristics of prostate cancer are needed. Radioimmunotherapy (RIT) uses a tumor-specific monoclonal antibody to deliver systemic, targeted radiation to cancer. The objectives of this Phase I study of (111)In-2IT-BAD-m170 (for imaging) and (90)Y-2IT-BAD-m170 (for therapy) were to determine the toxicity and maximum tolerated dose (MTD), the specificity for targeting metastatic prostate cancer, and the efficacy for palliation of pain. EXPERIMENTAL DESIGN: M170 is a mouse monoclonal antibody that targets adenocarcinomas. Patients with adequate renal and liver function, rising prostate-specific antigen, and androgen-independent metastatic prostate cancer were eligible. After estimation of dosimetry and pharmacokinetics with (111)In-2IT-BAD-m170, a single dose of (90)Y-2IT-BAD-m170 (0.185, 0.370, 0.555, or 0.740 GBq/m(2)) was administered to cohorts of three patients. Pain was assessed objectively by questionnaires before and for 8 weeks after RIT; weekly prostate-specific antigen levels were obtained for 2 months after RIT. RESULTS: The MTD of (90)Y-2IT-BAD-m170 was 0.740 GBq/m(2) for patients that had up to 10% of the axial skeleton involved with prostate cancer. Toxicity was almost exclusively confined to reversible myelosuppression. Metastatic prostate cancer was targeted by (111)In-2IT-BAD-m170 in all 17 patients. The mean radiation dose delivered to 39 bone and 18 nodal metastases by (90)Y-2IT-BAD-m170 was 10.5 Gy/GBq (range 2.8-25.1). Thirteen of 17 patients reported pain before (90)Y-2IT-BAD-m170; 7 of these 13 had a partial or complete resolution of pain that lasted an average of 4.3 weeks. CONCLUSIONS: This study determined the MTD of (111)In/(90)Y-2IT-BAD-m170 in patients with metastatic prostate cancer. The drugs were well tolerated, targeted metastases, and temporarily palliated pain.

Adenocarcinoma↗
PubMed1982

Prevalence of ocular disease in a population study of subjects 65 years old and older.

During a two-year period a randomly selected age-stratified sample of subjects 65 years old and older living in Gisborne, New Zealand, was examined by an ophthalmologist to investigate visual acuity and the prevalence of the major disorders of vision in old age. A total of 481 subjects (a response rate of 86.2%) completed the study. When the results were weighted to remove the effect of stratified sampling, the following prevalence rates for the population 65 years and over were obtained: cataract, 30.1% with no sex difference and an increasing prevalence with increasing age; senile macular degeneration, 6.4% with no sex difference and an increasing prevalence with increasing age; glaucoma, 3.6% with no sex difference except for women 90 years old or older who had a higher rate. The prevalence of glaucoma increased with increasing age in women, but in men there was no clear pattern; diabetic retinopathy, 0.5%. In the population 65 years old and older, we estimated that 81% of the men and 68.8% of the women had best corrected visual acuities of 6/9 (20/30) or better in the better eye.

Age Factors↗
PubMed1981

Falls in old age: a study of frequency and related clinical factors.

An analysis of falls experienced by a stratified population sample of 553 subjects, 65 years and over, was performed. It is estimated that one third of people 65 years and over experience one or more falls in a year. To analyse the association of physical and social variables with falls, the falls were divided into pattern falls and occasional falls. Pattern falls were those which, on history and examination, were assessed as arising from only minimal external upset and primarily from a disorder of balance or postural stability in the subject. Occasional falls were those which had arisen under circumstances which would be liable to cause a fit person to fall. Bivariate analysis showed those having pattern falls tended to have more functional disability, to have increased impairment of mobility, to use more aids to mobility, to be more depressed, to have lower mental test scores and to need more professional support. Women experiencing pattern falls also tended to be older and have poorer vision, while men had lower systolic blood pressure. Discriminant analysis showed that the principal effective 'predictors' of pattern falls in women were functional disability, the need for support services and informal help and the use of walking aids. In men they were functional disability and the need for support services and informal help.

Accidents↗