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Biomedical subjects

G S Savige

Publications and source records attributed to G S Savige.

6 recordsLinked to original sources
PubMed2003

Age-fitness. How achievable with food?

To be fit as we age could be described as "Age fitness". Increasing evidence points to opportunities for greater wellness, health maintenance and reduction of the burden of disease in later life for a growing proportion of the community than previously envisaged. The scope of "age fitness" is social, mental, physiological and physical. We know a great deal about food cultures associated with successful aging--Greek, Okinawan, and Scandinavian, for example. Within these cultures, we are beginning to account for variances in health and survival by integrative scores of food intake and their validation.

Activities of Daily Living↗
PubMed2001

Hypocholesterolemic effect of an enteric-coated garlic supplement.

OBJECTIVE: To evaluate the hypocholesterolemic effect of an enteric-coated garlic supplement standardized for allicin-releasing potential in mild to moderate hypercholesterolemic patients. METHODS: A double-blind randomized, placebo-controlled intervention study was conducted in 46 hypercholesterolemic subjects who had failed or were not compliant with drug therapy. Each subject was given dietary counseling to lower fat intake and enteric-coated Australian garlic powder tablets with 9.6 mg allicin-releasing potential or matching placebo tablets. RESULTS: After 12 weeks, the garlic supplement group (n=22) had a significant reduction in total cholesterol (TC, -0.36 mmol/L. -4.2%) and LDL-cholesterol (LDL-C, -0.44 mmol/L, -6.6%) while the placebo group (n=24) had a non-significant increase in TC (0.13 mmol/L, 2.0%) and LDL-C (0.18 mmol/L, 3.7%). HDL-cholesterol was significantly increased in the placebo group (0.09 mmol/L, 9.1%), compared to the garlic group (-0.02 mmol/L, -0.9%). and no significant difference in triglycerides or in LDL/HDL ratio was observed between groups. CONCLUSIONS: The study demonstrates that enteric-coated garlic powder supplements with 9.6 mg allicin-releasing potential may have value in mild to moderate hypercholesterolemic patients when combined with a low fat diet. Taken with other evidence, the efficacy of garlic for lipoprotein metabolism might require allicin bioavailability to be enhanced through the use of, for example, an enteric-coated dose form. If this is the case, the possibility remains that greater hypocholesterolemic efficacy may be evident at a higher allicin dose. Also noteworthy in this study was a small reduction in energy intake with garlic compared with placebo, attributable to reduction in fat, carbohydrate and alcohol intakes. This may also have contributed to the effects on blood lipids. This study suggests that garlic supplementation has a cholesterol-lowering effect, which may be mediated by direct action of a biologically active compound or compounds and in part through the effect on food and nutrient intake.

Administration, Oral↗
PubMed2001

Candidate foods in the Asia-Pacific region for cardiovascular protection: fish, fruit and vegetables.

Cardiovascular disease is a major cause of morbidity and mortality. Epidemiological studies indicate fish eaters are less likely to die prematurely compared with non-fish eaters. The protective properties in fish are likely to be related to its concentration of omega 3 fatty acids, calcium, selenium, vitamin D, taurine and coenzyme Q10. A high consumption of fruits and vegetables has been shown to protect against stroke and coronary heart disease. The presence of vitamins and minerals, as well as the complex array of non-nutrient compounds, found in fruits and vegetables would play an important role in this protection.

Animals↗
PubMed2001

Lifecycle nutrition and cardiovascular health: the aged.

As the world's population ages, cardiovascular health becomes increasing important. The ageing process gradually leads to a decline in the structure and function of the cardiovascular system. Other factors associated with ageing can hasten this decline, for instance, lifestyles that have become more sedentary. Additionally, the prevalence of hypertension, dyslipidaemia and diabetes, major risk factors for cardiovascular disease increase with age. Nutrition throughout the lifecycle can help prevent the development of these conditions and appropriate food habits instigated later in life can improve the management of these conditions and their impact on cardiovascular health.

Activities of Daily Living↗
PubMed1995

Nutritional disorders in the elderly.

Overnutrition and undernutrition can contribute to many common diseases or disorders in the elderly. Some conditions may take years to develop, while others can occur within weeks. Protein energy malnutrition may be the direct result of poor diet, or it may develop indirectly when other illnesses increase nutritional requirements beyond usual needs. One of the most easily recognised consequences of overnutrition is obesity, which is a risk factor for other diseases such as non-insulin-dependent diabetes mellitus, cardiovascular disease and hypertension. If nutritional disorders are identified and managed appropriately, the health of many elderly people can be significantly improved.

Aged↗