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Biomedical subjects

G S Sodhi

Publications and source records attributed to G S Sodhi.

10 recordsLinked to original sources

Development of latent fingerprints on compact disc and its effect on subsequent data recovery.

Chance fingerprints may be found on every type of surfaces of contact and when they are latent, need to be developed by various methods. The type of surface on which latent prints are to be developed is one of the important factors when a choice for a method of development is to be made. The matter becomes more crucial when the surface is unique like a compact disc containing digital data. In this case, to develop the fingerprints is not the only matter to be taken care of but also, is very important to select such a method which may not effect the stored data and its retrieval. In present investigation, various methods have been tried to develop fingerprints on the writing surface of a CD and results are discussed with respect to their development as well as its effect on stored data and data retrieval.

Charcoal↗

Powder method for detecting latent fingerprints: a review.

The powder technique for detecting latent fingerprints involves the application of a finely divided formulation to the fingermark impression, generally with a glass-fibre or a camel hair brush. The powder gets mechanically adhered to the sweat residue defining the ridge pattern. The furrows which are devoid of the fingerprint residue, do not adhere the powder onto them. The final outcome is that the powder formulation sticks to the ridges, but is easily blown off the furrows. Since the powder is normally coloured, the ridge pattern becomes visible and the latent print is said to have developed.

Adult↗

Fingermarks detection by eosin-blue dye.

Eosin-blue (I) dye, along with a phase transfer catalyst, has been used to detect latent fingerprints on a wide range of surfaces, including paper, glass, steel, lamination sheets, polythene, plastic and bakelite.

Dermatoglyphics↗

Organomercury (II) complexes with anti-carcinogenic agents. I. Synthesis and characterization.

A few organomercury (II) complexes involving anti-carcinogenic ligands have been synthesized. The compounds are of the type p-MeOC6H4HgL1 (I), p-NO2C6H4HgL2 (II), p-MeOC4H4HgL3 (III) and p-MeC6H4HgL4 (IV) (HL1-6-mercaptopurine, HL2-6-thioguanine, HL3-5-fluorouracil, L4-phenyldithiocarbazate). Their composition has been determined from elemental analysis. Thin layer chromatography (TLC) studies demonstrate that the compounds are pure. Conductance measurement reveal that these derivatives are non-electrolytes. From IR and UV spectral studies the bonding modes of the ligands to the mercury (II) ion have been elucidated. The stoichiometry of the compounds has been confirmed on the basis of 1H and 13C NMR spectra. Some preliminary results of anti-neoplastic activity are reported.

Antineoplastic Agents↗

Organomercury (II) complexes with anti-carcinogenic agents. II. Anti-neoplastic activity.

Organomercury(II) complexes of the type, p-MeOC6H4HgL1 (I), p-NO2C6H4HgL2 (II), p-MeOC6H4HgL3 (III) and p-MeC6H4HgL4 (IV) (HL1-6-mercaptopurine, HL2-6-thioguanine, HL3-5-fluorouracil, L4-phenyldithiocarbazate) have been screened against the following cell panels: leukemia, non-small cell lung cancer, small cell lung cancer, brain cancer, melanoma, ovarian cancer and renal cancer. The variation in anti-neoplastic activity has been correlated with the structural parameters of the complexes.

Antineoplastic Agents↗

Organomercury(II) complexes of kojic acid and maltol: synthesis, characterization, and biological studies.

A number of organomercury(II) complexes of kojic acid (HL1, I) and maltol (HL2, II) of the type p-XC6H4HgL1 (III) and p-XC6H4HgL2 (IV) [X = Me, MeO, NO2] have been synthesized and characterized. [formula: see text] Conductance measurements indicate the nonelectrolyte behavior of the complexes. From IR and UV studies, the bonding modes of the ligands to the organomercury(II) moieties have been elucidated. The 1H and 13C NMR spectra support the stoichiometry of the complexes. The fragmentation pattern has been analyzed on the basis of mass spectra. From thermal studies (TG and DTA), various kinetic and thermodynamic parameters for thermal degradation have been enumerated. The complexes have been screened against some pathogenic bacterial strains. The bactericidal activity has been correlated with the thermal data.

Anti-Bacterial Agents↗

Diuretic activity of organomercury (II) complexes of theophylline and theobromine.

Organomercury(II) complexes of the types, p-XC6H4HgL (A) and p-XC6H4HgCl(L') (B) [LH = theophylline; L' = theobromine; X = Me, NO2], have been synthesised and characterized. Conductance measurements indicate that the complexes are non-electrolytes. The structures of the complexes have been elucidated by spectral studies (IR, UV, and 1H, 13C NMR). The complexes have been tested for diuretic activity. The structure-activity relationship has been propounded.

Animals↗

Organomercury(II) complexes of 6-thioguanine: synthesis, characterization, and biological studies.

Organomercury(II) complexes involving 6-thioguanine, of the type p-XC6H4HgL (Fig. 1) [LH = 6-thioguanine; X = Me, MeO, NO2], have been synthesized and characterized. Conductance measurements indicate that the complexes are nonelectrolytes. From IR and UV studies, it is concluded that 6-thioguanine acts as a bidentate ligand, coordinating through the 6-thione group and deprotonation of N-7. 1H and 13C NMR support the stoichiometry of the complexes. From thermal studies (TG and DSC) various kinetic and thermodynamic parameters for thermal degradation have been enumerated. In addition, the fragmentation pattern of the complexes have been analyzed on the basis of mass spectra. The p-MeC6H4HgL and p-MeOC6H4HgL complexes display significant activity against L1210 leukemia cells.

Animals↗

Studies on organomercury(II) complexes of isoniazid.

A number of organomercury(II) complexes involving isoniazid (I), of the type RHgCl(L)(II) [R = phenyl(C6H5), o-hydroxyphenyl (o-HOC6H4), p-hydroxyphenyl (p-HOC6H4), p-acetoxyphenyl (p-AcOC6H4), 2-furyl (2-C4H3O); L = isoniazid] have been synthesized and characterized. Conductance measurements indicate that the complexes are nonelectrolytes. From IR and UV studies, it is concluded that isoniazid acts as a bidentate ligand, coordinating through hydrazinic nitrogen and carbonyl oxygen. 1H and 13C NMR support the stoichiometry of the complexes. From fluoroscence studies a number of photochemical parameters have been elucidated. For the C6H5HgCl(L), p-HOC6H4HgCl(L), and p-AcOC6H4HgCl(L) complexes, thermogravimetric studies have been carried out and relevant kinetic and thermodynamic parameters for thermal degradation have been enumerated. In addition, the fragmentation pattern of the complexes has been analyzed on the basis of mass spectra. The C6H5HgCl(L) and p-HOC6H4HgCl(L) complexes have been screened for tuberculosis activity.

Chemical Phenomena↗