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Biomedical subjects

G S Voronkov

Publications and source records attributed to G S Voronkov.

At least 19 recordsLinked to original sources
PubMed1991

[The data from clinical, instrumental and laboratory studies as markers in the prognosis of the restabilization process in patients with a history of unstable stenocardia].

With the purpose of preventing the development of acute clinical ischemic lesions of the myocardium, and their further progression, regression of coronary atherosclerosis the authors followed up for more than one year 250 patients with unstable stenocardia and singled out two groups of these patients, each group having important differences as to coronary reserve, functional state of the myocardium, lipid spectrum, dynamics of vasoactive substances, immunological reactivity, thrombocytic activity. Early detection of groups with an unfavourable course of IHD in patients with unstable stenocardia will allow to optimize treatment and avoid development of acute coronary catastrophies.

Adult↗
PubMed1987

Antioxidants as antiarrhythmic drugs.

Experiments on rats and rabbits using models of arrhythmias induced by vasopressin, epinephrine, strophanthin, and CaCl2 showed that antioxidants derived from 1,4-dihydropyridines, dibunol, and alpha-tocopherol possessed antiarrhythmic effects. Administration of these antioxidants decreased the occurrence of extrasystoles, disturbances of atrioventricular conductivity and ventricular fibrillation. These drugs also prevented changes in membrane phospholipid composition, inhibited activation of peroxidation, decreased phospholipase activity, prevented a decrease of Ca2+ ATPase and Ca2+ binding and uptake by sarcoplasmic reticulum, and increased sarcolemmal Na+, K+-ATPase, sarcoplasmic reticulum creatine phosphokinase.

Animals↗
PubMed1986

[One approach to the study of heterogeneous convergence in the olfactory bulb].

The experimental model for studying the convergence of the heterotype olfactory receptors on the single secondary neuron of the olfactory bulb is proposed. The secondary neuron with bilateral connections (with both olfactory epithelia) in the animals with fused olfactory bulb may serve such a model. The intracellular recording from these secondary neurons of the fused frog's bulb have revealed the secondary neurons which were activated by a certain odorant stimulation of only the one olfactory epithelium, the same odorant stimulation of the other epithelium did not activate (or inhibit) the neurons. The data obtained show that the inputs on the secondary neurons are heterotype, i. e. show the heterogeneous convergence of sensory information on the secondary neurons.

Animals↗
PubMed1983

[Creatine phosphokinase activity in myocardial sarcoplasmic reticulum membranes in experimental coronary insufficiency].

Experiments on rats with acute coronary blood flow restriction (intravenous injection of vasopressin in a dose of 0.5 units/kg) have shown a decrease in the activity of creatine phosphokinase (CPK) and activation of lipid peroxidation in sarcoplasmic reticulum (SPR) membranes. These changes were attended by structural abnormalities in the membrane apparatus of the SPR, primarily on the part of the lipid composition. Pretreatment (1 h before vasopressin) of the animals with the antioxidant AV-156Na averted the development in the SPR membranes of the changes described. This evidences that the rate of peroxide reactions in the myocardium might determine in many respects the metabolic and structural supply of the cell apparatus.

Animals↗
PubMed1976

[Complex action potentials of the secondary neurons of the rat olfactory bulb].

Complex action potentials (background and evoked by the lateral olfactory tract stimulation) were recorded from the secondary neurons of the olfactory bulb. The amplitude and duration of the complex action potentials changed depending on the synchronous appearance and combination of their elementary components. It is supposed that they were recorded in cases when the electrode was located near the spike-generating zones and that there are many such zones in the dendrites of the secondary neurons. The evoked action potentials appeared with different latencies (about 1 ms, about 2 ms, about 3 ms). Data are presented indicating that the antidromic response arises with the first latency and the responses with other latencies are synaptic. Synaptic responses were found more often than antidromic ones. These data suggest a variable representation of excitatory synapses in the secondary neurons (besides the excitatory olfactory glomerulus input).

Action Potentials↗