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Biomedical subjects

G Sødal

Publications and source records attributed to G Sødal.

66 records · Page 4Linked to original sources
PubMed1981

HLA-restricted cell-mediated cytotoxicity directed against male specific (H-Y) antigen after acute rejection of an HLA-identical sibling kidney.

A 22-year old female patient who received a kidney from her HLA-A, -B, -C and D/DR identical brother (HLA-A2, 28; B7, 14; DR1/2) acutely rejected the graft 2 1/2 weeks post transplantation. In vitro tests 1 month later, using recipient responding cells and donor stimulating/target cells, revealed: No direct cell-mediated lympholysis (CML), but strong CML against donor target cells after priming in mixed lymphocyte cultures (MLC). Testing these cytotoxic cells from the patient on the panel of non-related target cells, we found positive CML only against target cells from male donors carrying HLA-A2 and/or -B7 specificities. Both MLC and CML tests using donor responding cells and recipient stimulating and target cells were negative. These findings indicate an HLA restricted cytotoxicity against a male-specific minor histocompatibility antigen, which may be the cause of rejection in this case.

Adult↗
PubMed1981

Umbilical vein grafts and PTFE grafts for femoro-popliteal bypass. Preliminary results.

This retrospective, multiple-center study includes 172 PTFE (Gore-Tex) and 35 umbilical vein grafts (Bio-graft) used for femoro-popliteal bypass grafting. The one-year patency rate was approximately 63% in both groups. Until further experience is accumulated, autogenous saphenous vein should probably be the first choice for femoro-popliteal bypass grafting. Prosthetic grafts should preferably be used when the saphenous vein is absent or insufficient.

Aged↗
PubMed1980

Surgical correction of renovascular hypertension in patients with one kidney. A report of 9 cases.

Nine patients with severe renovascular hypertension underwent surgical revascularisation of their single kidney. The blood pressure normalized postoperatively in seven patients. Four of them no longer required antihypertensive medication and three required only moderate doses. One patient died of myocardial infarction three days after the operation. The ninth patient also became normotensive, but preoperative renal failure progressed and she died of cardiac failure while on haemodialysis 16 months postoperatively. The results suggest that single-kidney renovascular hypertension is more amenable to surgery than is unilateral disease in patients with two kidneys, because the hypertensive effect of the other kidney is lacking.

Adult↗
PubMed1980

Aorto-enteric fistula. A case treated with insertion of a new dacron prosthesis and bilateral autotransplantation of the kidneys.

A 54-year-old woman was treated for an aortic aneurysm with a Dacron-Y-prosthesis. Four years later she developed GI bleeding lasting for five months before the diagnosis of an aorto-enteric fistula was made. The fistula was caused by a total disrupture of the proximal graft anastomosis with formation of a huge pseudoaneurysm involving both renal arteries. Treatment included fistula closure, insertion of a new Dacron graft and bilateral renal autotransplantation with complete recovery.

Aorta, Abdominal↗
PubMed1979

Surgical correction of subclavian steal syndrome.

Eleven patients with subclavian steal syndrome underwent surgical correction without mortality. Ten patients were relieved from their symptoms. Two vessels reoccluded, two months and three years postoperatively, with reappearance of symptoms. One patient was hemiplegic after the operation. Associated lesions of other precerebral vessels were found in 7 patients, and surgical correction of two or three stenosed or occluded arteries was performed in 5 of them. Satisfactory and complete preoperative angiographic study of all precerebral vessels is therefore important. In 4 patients studied, the vertebral artery flow changed from a mean retrograde flow of 91 ml/min to a mean forward flow of 64 ml/min.

Blood Flow Velocity↗
PubMed1978

Clinical results with 131I-toluidine blue and triple radionuclide subtraction for preoperative localization of enlarged parathyroid glands.

Clinical results from the application of a triple radionuclide subtraction study for preoperative localization of enlarged parathyroid glands are presented in this paper. A scintillation camera image was recorded after i.v. injection of 131I-toluidine blue. The contributions to this image from activity in the thyroid gland and in blood were determined after recording of additional images (obtained after injection of 99mTcO4- and 113mIn, respectively) using an iterative computer algorithm that also provides an estimate for a uniform background. Subtraction of these contributions gives an image that may be interpreted as an image of the selective accumulation of 131I-toluidine blue in the parathyroids. One or more enlarged glands were correctly localized in 17 of 21 cases, but in four cases there were only false positives. In ten cases the correctly localized glands weighed 900 mg or less.

Adult↗
PubMed1977

Kidney transplantation in diabetic nephropathy: four years experience.

Since 1972 65 patients with diabetic nephropathy have been evaluated for renal transplantation. Twenty one were not accepted, 6 died before transplantation and 10 are still under observation. Of 28 transplanted patients 13 are alive with functioning graft, and 3 are treated with hospital dialysis. Patient survival at one year was 65% and graft survival 50%.

Adult↗
PubMed1977

Antilymphocyte globulin in cadaveric renal transplantation--a controlled trial.

In a prospective, controlled study, 40 patients receiving a cadaveric renal transplant (first grafts) were randomized into two groups. Twenty patients were given antilymphocyte globulin (Behringwerke AHLG) in a dose of 10 mg/kg body weight for a total no. of 25 times in combination with a standard regimen of prednisone and azathioprine. Graft survival and graft function were similar in the two groups both at 18 and 30 months post transplantation. No serious side effects of the ALG treatment were observed.

Adult↗
PubMedDate not supplied

Renal autotransplantation.

In the period, 1973-1985, a total of 305 renal autotransplantations (often with extracorporeal repair) were performed in 274 patients for fibromuscular (56) or atherosclerotic (98) renovascular disease, nephrolithiasis (97), renal tumor (15), or ureteral injury (8). One-third of the patients had reduced renal function, and approximately half of the patients with renovascular lesions presented with severe or malignant hypertension. The postoperative mortality rate of 4% was related to age over 60 years and reduced renal function. Postoperatively, 3.6% of the autografted kidneys were lost due to vascular thrombosis (7) or other causes (4). Twenty-five percent (69) of the patients had a solitary kidney. Two patients died postoperatively with functioning autografts. Long-term renal function remained stable in 60 patients, and deteriorated in 7. We conclude that autotransplantation and extracorporeal repair provide safe and efficient treatment for selected difficult renal lesions.

Adolescent↗