G Sage | PubMed Health

PubMed1986

Patients who break their fast before ECT.

Of 81 patients receiving ECT during a period of 24 months, 21 ate or drank something, against medical advice, shortly before ECT was due. Compared with controls, the fast-breakers were less often married; were more likely to be detained under a section of the Mental Health Act; had an unfavourable view of ECT; and had often not given consent for ECT. Fast-breaking was more likely to occur after four or more ECTs. Amongst the fast-breakers there was a significant correlation between age and number of previous ECTs; treatment at which the fast-break occurred. The more drugs the patient was taking the more likely it was that the fast would be broken early in the course of ECT.

Adult↗

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Immune response to rabies vaccine in Alaskan dogs: failure to achieve a consistently protective antibody response.

Previous studies in Thailand and Tunisia have shown that one injection of dog pre-exposure rabies vaccine does not produce a lasting antibody titre in a significant group of animals. We therefore duplicated the Thai study in a small North American community using healthy, owned dogs. A tissue culture vaccine of known high antigenicity was given intramuscularly as one primary injection and antibody titres were determined by the rapid fluorescent focus inhibition test on days 14, 30, 60, 180 and 360. Titres were less than 0.5 i.u./mL in 27% of dogs bled at 2 months, 24% at 6 months, and in 33% one year after the primary vaccination. In rabies endemic regions, it may be hazardous to rely on the previous vaccine history of a biting dog when making post-exposure management decisions. A retrospective study of antibody levels in previously vaccinated dogs in North America also indicated that a single injection of vaccine often failed to result in adequate titres.

Animals↗