Biomedical subjects

G Salmeron

Publications and source records attributed to G Salmeron.

4 recordsLinked to original sources

PubMed1989

Cutaneous T cell lymphoma with suppressor phenotype and function.

Cutaneous T cell lymphomas (CTCL) are typically malignancies of postthymic helper T cells which retain helper function when assayed in vitro. We have described a case clinically and morphologically consistent with CTCL, but in which the tumor cells unequivocally had a suppressor T cell phenotype and suppressor function. This case could be differentiated from other varieties of peripheral T cell lymphomas by multiple clinical and laboratory parameters. The increasingly routine use of immune phenotyping in the evaluation of malignant lymphomas will likely result in the identification of additional cases of this entity, which should be studied to assess its clinical and prognostic relationship to the more common helper cell CTCL.

Humans↗

PubMed1983

Immunosuppressive potential of antimalarials.

A hypothesis concerning the mechanism whereby chloroquine phosphate and hydroxychloroquine sulfate are therapeutically active in rheumatoid arthritis is presented, based on in vitro data that (1) utilize drug concentrations not higher than those clinically achievable, and (2) might explain mechanisms that may be applicable in treated rheumatoid arthritis patients. Simple assay systems were used: normal human peripheral blood mononuclear cells were cultured, stimulated with various nonspecific agents, and assayed either for induction of T cell proliferation or generation of immunoglobulin-secreting cells. Results indicate that chloroquine inhibits tritiated thymidine in a dose-dependent way by interfering with the accessory function of monocytes, and that chloroquine inhibits the generation of immunoglobulin-secreting cells by selectively interfering with the secretion of Interleukin 1 by monocytes.

Arthritis, Rheumatoid↗

PubMed1981

Polymyositis and diffuse interstitial lung disease. A review of the pulmonary histopathologic findings.

A retrospective analysis was performed of 105 patients with polymyositis for eight years. Roentgenographic evidence of pulmonary interstitial disease was present in ten adult patients (9%) with polymyositis unassociated with other connective-tissue disorders. Review of the pulmonary histopathologic findings indicated a spectrum of pulmonary diffuse interstitial infiltrates and fibroplasia of the alveolar septae. Response to glucocorticoids with regard to pulmonary symptoms was variable in the patients studied. Therapeutic response seemed to be influenced by both the cellularity of the chronic interstitial infiltrates and the degree of fibroplasia of the alveolar septae. Electron microscopic studies of the lung tissue from two patients with polymyositis and diffuse interstitial lung disease failed to demonstrate either immune complexes or viral particles.

Female↗

PubMedDate not supplied

Modulation of human immune responsiveness in vitro by auranofin.

The effect of auranofin (AF) on in vitro correlates of human immune responsiveness was examined. AF inhibited mitogen induced human lymphocyte proliferation and the generation of immunoglobulin secreting cells in a concentration dependent manner. The inhibition was most effective when AF was present from the initiation of culture indicating that this drug blocked a critical early step in lymphocyte activation. Marked inhibition of mitogen responsiveness was observed as a result of a 1-h preincubation with AF. The brief preincubation with low concentrations of AF (0.3 micrograms/ml) resulted in a selective inhibition of the accessory function of monocytes but had no effect on potential lymphocyte responsiveness. Preincubation with higher concentrations of AF (greater than 0.6 micrograms/ml) resulted in a more non-specific inhibition of both monocyte and lymphocyte function. These data support the conclusion that AF may function as an immunosuppressive agent.

Antibody Formation↗