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Biomedical subjects

G Samama

Publications and source records attributed to G Samama.

At least 37 records · Page 2Linked to original sources

[Celioscopic treatment of perforations of duodenal ulcers. 6 cases].

Traditionally, perforations of duodenal ulcers are managed by suturing followed by peritoneal lavage and the underlying cause is addressed secondarily. Laparoscopy provides a means of meeting the different therapeutic needs. From May to October 1993, we treated 6 consecutive perforations of duodenal ulcers laparoscopically. In 5 cases, the perforation was the first manifestation of acute duodenal ulceration and the other case was chronic. The laparoscopic operation included peritoneal lavage and simple suture of the ulcer. The immediate post-operative period was uneventful. With a current follow-up of 3.6 months, 5 patients are asymptomatic and ulcer cicatrization has been confirmed by fibroscopy. In the sixth case with a past history of chronic duodenal ulcer, re-operation was required after a delay of 2 months for acido-fundic vagotomy (performed laparoscopically). The local presentation was satisfactory in this patient. Extensive peritoneal lavage, which can be performed with laparoscopy together with suture when the ulcer is recent, allows managing such patients according to Taylor's method. The usefulness of vagotomy can then be addressed and performed later laparoscopically after the initial lavage. This new approach offers a means of complete cure and has all the advantages of the classical technique.

Acute Disease↗

Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations.

BACKGROUND: The benefits of preoperative chemotherapy and radiation for esophageal carcinoma are under investigation. A pilot study was undertaken to determine if pathologic assessment of tumor regression correlated with disease free survival. METHODS: Ninety-three resected specimens from patients treated with cis-dichloro-diamino cisplatin and irradiation before surgery were examined on semiserial sections. Patients selected for surgery were all Status 1 according to the World Health Organization (WHO) classification. Histologic typing was based on the WHO classification. Tumor regression grade (TRG) was quantitated in five grades: TRG 1 (complete regression) showed absence of residual cancer and fibrosis extending through the different layers of the esophageal wall; TRG 2 was characterized by the presence of rare residual cancer cells scattered through the fibrosis; TRG 3 was characterized by an increase in the number of residual cancer cells, but fibrosis still predominated; TRG 4 showed residual cancer outgrowing fibrosis; and TRG 5 was characterized by absence of regressive changes. Survival curves were estimated according to the Kaplan-Meier method. A quantification of the relationship between treatment failure and confounding variables (age, tumor location, tumor size, esophageal wall involvement by residual cancer and/or regressive changes, histology, treatment, adequacy of surgery, pathologic lymph node status, and tumor regression grade) was done using Cox's proportional hazards model. RESULTS: Forty-two percent of specimens were TGR 1-2; 20%, TGR 3; and 33%, TGR 4-5. Univariate analysis found that tumor size, pathologic lymph node status, tumor regression grade, and esophageal wall involvement were highly correlated with disease free survival (P < 0.05). After multivariate analysis, only tumor regression (i.e., TRG 1-3 versus TRG 4-5) remained a significant (P < 0.001) predictor of disease free survival. CONCLUSIONS: This study highlights the importance of tumor regression in the survival of patients with esophageal carcinoma treated with preoperative chemoradiotherapy. These findings suggest that tumor regression grade should be considered when evaluating therapeutic results.

Adult↗

[Pelvic lymphoceles after kidney transplantation. Intraperitoneal marsupialization by celioscopy].

OBJECTIVES: The appropriate treatment for symptomatic pelvic lymphoceles occurring after renal transplantation is still debated. External drainage exposes to risk of recurrence, infection or graft sclerosis and laparotomy has been required for intraperitoneal marsupialization in patients at risk. We report our experience with two cases treated by laparoscopic intraperitoneal marsupialization. PATIENTS: From November 1986 to September 1992, 170 renal transplantations were performed at our University Hospital. Lymphoceles developed in 12 cases and percutaneous puncture and irrigation was performed in all, successfully in 10. Relapse occurred in 2 patients--one 50-year-old woman with chronic glomerulonephritis and one 41-year-old man on peritoneal dialysis for polycystic renal disease--recipients of cadaver kidneys. SURGICAL TECHNIQUE: The laparoscopy was conducted under general anaesthesia. Four trocars were inserted, a 10 mm via the umbilicus for the optical system and three 5 mm trocars via the right and left flank and the left iliac fossa. A long puncture needle was used to drain the lymphocele and a localized collection and a large peritoneal window was created. The abdominal cavity was abundantly washed before withdrawing. RESULTS: Operation time was 35 minutes and conversion to laparotomy was not required. The only complication was a haematoma at one insertion site. Patients were discharged on day 2 and on day 1 with an unchanged immunosuppressor regimen. At 10 months follow-up, the patients were symptom-free and echography was normal. CONCLUSIONS: Surgical treatment of lymphoceles can be successfully performed by laparoscopy. The choice between conservative treatment and laparoscopic surgery remains to be determined.

Adult↗

Treatment of adenocarcinoma of the pancreas with somatostatin and gonadoliberin (luteinizing hormone-releasing hormone). The French Associations for Surgical Research.

Experimental studies have shown a significant inhibition of adenocarcinoma of the pancreas by gonadoliberin (luteinizing hormone-releasing hormone [LH-RH]) and somatostatin. The aim of this prospective randomized study was to compare the potential value of somatostatin (250 micrograms every 8 hours), LH-RH (3.75 mg monthly), or combined, to a control group. One hundred sixty-three patients with adenocarcinoma of the pancreas who did not undergo resection for cure were divided into 4 groups that did not differ in terms of clinical, biologic, or pathologic data. The mean survival times were 6 months in the LH-RH plus somatostatin group, 5.5 months in the LH-RH group, 4.3 months in the control group, and 3.8 months in the somatostatin group. However, the life-table analyses for all randomized patients, and separately according to sex, the lymph node extension, and metastatic spread were not different between groups. Improvement of patient status was observed in 20% of the patients receiving hormone therapy without any difference noted between the treatment regimens. These disappointing results may be explained by the degree of extension of pancreatic carcinoma in the patients studied. The results suggest that different hormone therapy regimens might be considered according to the age and the sex of patients, as well as to the presence or absence of hormone receptors.

Adenocarcinoma↗

[Short hospitalization in routine surgery. Experience with an unselected population].

Three hundred and ninety eight consecutive patients about to be operated upon for inguinal hernia (165), varicose veins (101) or thyroid gland hyperplasia (132) were offered short stay surgery. Patients who left the hospital at day 1 and those who left after day 1 for personal convenience were compared as regards age, sex, occupation, one-sided or two-sided pathology, assisted or non assisted convalescence, life style and drug consumption after discharge. Hernia patients showed no difference in all these parameters. Among varicose vein patients, the proportion of short stay refusals was significant only in women. As for patients undergoing thyroidectomy, only those who had simple lobectomy were in the short stay group. In all cases, short stay had no adverse effect. The main obstacle to short stay surgery might well be the patient himself, as he benefits from full social cover and has access to surgical treatment without being on a long waiting list.

Adolescent↗

[Adjuvant radiochemotherapy in operable cancers of the thoracic esophagus. Preliminary results of a multicenter study. A study of 119 cases].

119 operable patients with an oesophageal squamous cell carcinoma were treated preoperatively by a combination of radiotherapy (37 Gy in two courses) and chemotherapy by cisplatin (delivered before each course of radiation). The response was evaluated on the resected specimen. 111 patients underwent operation and 101 tumours were resected. The toxicity was acceptable by reducing the Cisplatin dosage from 100 mg/m2 to 80 mg/m2 for the last 67 patients. A complete response was observed in 24 patients and a partial response in 46. The preliminary results show a 57% eighteen-month survival in the group of resected patients. A controlled study is needed to compare this combined regimen versus surgery alone in curatively resectable patients.

Adult↗

[Splenectomy in Gaucher's disease. Apropos of 2 cases, one of which was preceded by embolization].

Two cases of Gaucher's disease type I are reported Splenectomy was indicated because of hypersplenism and massive splenomegaly. In one case hypersplenism was treated with pre-operative selective embolization because of the volume of the spleen (20 kg). The embolization corrected the thrombopenia but not the size of the spleen. Four years after operation for case 1 and eight months for case two, there is an improvement in the clinical status.

Child↗

[Radiation enteritis after pelvic irradiation of cancer of the rectum. Prevention by omentoplasty and pelvic partitioning with polyglactin 910 mesh].

To prevent radiation enteritis during post-operative irradiation of the pelvis for rectal carcinoma, the greater omentum, fed by the left gastro-epiploic pedicle, is pulled down into the pelvis which is separated from the abdomen by an absorbable polyglactin 910 mesh. The mesh, under tension, is attached superiorly to the lips of the posterior peritoneal section and anteriorly to the upper border of the pubis. This procedure has been used in seven patients, four of whom have been irradiated post-operatively without any gastrointestinal complication.

Enteritis↗

[One-stage treatment of neoplastic occlusions of the left colon. Apropos of 3 cases. Review of the literature].

The authors report of 3 news of subtotal colectomy with immediate anastomosis in the treatment of neoplastic occlusion of the left colon. They review all the cases (153) actually published. The advantages of this technic are: treatment of the occlusion and of the cancer in one stage; quicker social rehabilitation (14.8 days) useful overall in patients whom survival is short, lower mortality rate (10.45%) lower morbidity rate (25.6%) and quite none sequellae.

Adult↗

[Cancers of the left colon with occlusion. Treatment by subtotal colectomy with immediate ileo-sigmoid anastomosis].

The technique of subtotal colectomy with immediate ileo-sigmoid anastomosis in the treatment of the carcinoma of the left colon revealed by obstruction is described. This operation treats, in one stage, both the obstruction and the cancer. The mortality, morbidity and duration of stay in hospital are less than with the usual sequential treatment. Social rehabilitation is quicker, which is particularly valuable since the expected survival of these patients is short due to old age, poor general condition or spreading of the malignancy.

Aged↗

[Treatment of gastroesophageal reflux. Value of parietal cell vagotomy associated with Nissen's fundoplicature].

The authors use parietal cell vagotomy as a routine procedure associated with the Nissen fundoplicature in the treatment of gastro-oesophageal reflux. The advantages of parietal cell vagotomy evaluated in 14 patients were: lower acid secretion without necessity of drainage; best exposure of the gastro-oesophageal junction from the right side without any surgical risk to the spleen; lengthening of the abdominal oesophagus and mild or no sequelae from the parietal cell vagotomy.

Adult↗