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Biomedical subjects

G Samori

Publications and source records attributed to G Samori.

10 recordsLinked to original sources

[Angiographic diagnosis in intestinal angiodysplasia. Series of 13 cases].

The authors report 13 cases of intestinal bleeding; while serials endoscopic and radiological examinations had been negative, arteriography allowed intestinal angiodysplasia to be diagnosed, and detected 18 lesions (12 of the right colon, 6 of the small bowel), confirming the fundamental role of arteriography in the diagnosis the localization and extension of these lesions. The importance of accuracy is emphasized both in the performance and in the evaluation of angiographic findings, in order to avoid missing multiple localizations (colon and small bowel). The authors illustrate and evaluate the different angiographic findings. Among these, the collection of contrast medium into parietal vascular lacunae and the early and dense opacification of the draining veins appear to be the most specific and frequent findings of angiodysplasia. In their series of patients the authors have also observed how the dilatation of the feeding artery, up to the antimesenteric side (a sign which is hardly ever reported in literature), was often present in the cecal localizations but could never be observed in the small bowel. Finally the surgical results and follow-up are considered.

Adolescent↗

[Intestinal angiodysplasias. Diagnostic and therapeutic problems].

The cases are presented of 9 patients with intestinal angiodysplasia observed in 1979-85 in the surgery departments of San Carlo Borromeo Hospital, Milan. Diagnostic problems are discussed with particular reference to angiographic and endoscopic methods. Surgical treatment gave good results. Recurrent bleeding may depend on the inadequate assessment of the extension of the lesion or on the existence of other unrecognised intestinal sites.

Adolescent↗

[Locoregional chemotherapy of liver metastasis from colorectal carcinoma].

Hepatic metastases are a major cause of death in patients with colorectal carcinoma. Traditional intravenous chemotherapy produces responses in 10% to 30% of patients and surgical resection is feasible in approximately 20% of patients. Infusion of cytotoxic agents into the hepatic artery is the most promising form of therapy for unresectable hepatic metastases. The recent development of a totally implantable pump has allowed prolonged infusion of chemotherapeutic agents with a good compliance and quality of life of the patients. The rationale for hepatic arterial infusion (HAI) present an anatomical and pharmacological basis with the use of agents with high hepatic extraction resulting in minimal systemic toxicity. The results of eight randomized trial assessing the value of HAI Floxuridine shows that such regional chemotherapy increases the likelihood of hepatic response compared with systemic treatment (52% vs 15%). Survival information is difficult to evaluate because some of the studies are small, some had a crossover design and some others had bias factors. Extrahepatic disease develops in 40-70% of patients undergoing HAI; the use of systemic therapy plus HAI may produce a decrease in extrahepatic disease. Further studies of combined systemic/arterial regiment are necessary.

Antineoplastic Agents↗