PubMed Health⌕ Search

Biomedical subjects

G Sanfilippo

Publications and source records attributed to G Sanfilippo.

At least 19 recordsLinked to original sources
PubMed2005

Pre-surgical finasteride therapy in patients treated endoscopically for benign prostatic hyperplasia.

INTRODUCTION: Transurethral resection of the prostate is considered the standard technique for patients with moderate or severe lower urinary tract symptoms related to benign prostatic hyperplasia (BPH). Pathologically BPH is characterized by an increased proliferation of stromal and acinar cells, sustained by increased vascularization (neoangiogenesis). Recent studies have also shown that finasteride reduces angiogenesis and prostatic bleeding associated with BPH. Reducing the volume as a final step in reducing neoangiogenesis could thus represent a fundamental advance in limiting intra- and postoperative bleeding in patients undergoing transurethral resection of the prostate (TURP). MATERIALS AND METHODS: Our study included 60 patients undergoing TURP between January 2001 and January 2002. Of the patients, 30 received pretreatment with finasteride while 30 did not undergo any pretreatment (control group). In all the patients we evaluated the degree of peri-surgical bleeding, intended as a reduction in hemoglobin values in the 24 h following surgery. RESULTS AND CONCLUSIONS: In the group of patients pretreated with finasteride, blood loss, evaluated as a reduction in hemoglobin values, was minimal, and none of the patients required blood transfusion. The average hemoglobin loss in the 24 h following surgery was 0.9%. In the control group (average age 67 years), 4 patients (12%) required blood transfusion. The loss of hemoglobin was 2.36%. Finasteride, therefore, seems to play a fundamental role in the pretreatment of TURP patients, since by reducing dihydrotestosterone synthesis, it interacts with endothelial growth factors, thus reducing angiogenesis and preventing bleeding.

Aged↗
PubMed2000

[Usefulness of ultrasonography in the diagnosis of acute scrotal edema].

Ultrasonography has gained an important role for the diagnosis of acute and chronic scrotal lesions. We report our experience on 6 cases of acute scrotal edema. The etiology of edema was congestive cardiopathy (two patients), glomerulonephrosis (three patients) and lumboaortic lymphnode metastases from bladder transitional cell carcinoma (one patient). Ultrasound scan scrotal appearances were similar in all examined patients, and the only pathologic findings observed were "onion" like appearance and a thickened scrotal wall. Therefore, to define acute scrotal edema etiology, it isn't enough an ultrasound examination, but it's necessary to extend the ultrasound scan assessment to other organs.

Acute Disease↗
PubMed1995

[Evaluation of sensitivity and specificity of antigliadin antibodies for the diagnosis of celiac disease in childhood].

A retrospective study with the aim of evaluating sensitivity and specificity of antigliadin antibodies (AGA) was carried out. AGA values, IgA and IgG, and mucosal damage at intestinal biopsy were compared in each subject, on a sample of 245 subjects, who had undergone intestinal biopsy because of suspected coeliac disease (CD), from January 1991 to December 1993. 130 subjects (53.1%) were found to be suffering from CD, whereas the remaining 115 subjects (46.9%), who did not show any signs of the disease, were considered as controls. When we compared AGA values with mucosal damage we observed that IgA were normal in 24 (18.5%) and pathological in 106 (81.5%) coeliac patients, whereas they were normal in 107 (93%) and pathological in 8 (7%) controls. IgG values were normal in 17 (13.1%) and pathological in 113 (86.9%) coeliac patients, but normal in 75 (65.2%) and pathological in 40 (34.8%) controls. Data about AGA sensitivity related to age, showed IgA sensitivity varying from 80.4% in children under 1 year old to 70% in children over 10 years old and IgG sensitivity from 94.1% to 50%. Data about specificity related to age, showed IgA sensitivity varying from 78.7% in children under 1 year old to 100% in children over 10 years old and IgG specificity from 30.4% to 90.9%. Our results indicated that AGA-IgA had a total sensitivity or 81.5%, a total specificity of 93% and a concordance with intestinal damage of 86.9% while AGA-IgG had a total sensitivity of 86.9%, a total specificity of 65.2% and a concordance with intestinal damage of 76.7%. These data presented a modification on the basis of age, being higher in children under 3 years of age and decreasing with the increase in age. We conclude that AGA have great importance in suspect CD, but it is most important that their results are evaluated on the basis of age.

Antibodies↗
PubMed1992

[Nonparasitic hepatic cysts].

Serous cyst of the liver are a rare pathology which are often diagnosed during surgery. The paper reports 12 cases which were diagnosed during laparoscopy and discusses the etiopathogenesis of the disease, the latest diagnostic tools and the possible use of surgery. In conclusion, the Authors affirm that surgical laparoscopy represents an alternative form of treatment in some cases, such as polycystic liver.

Adult↗
PubMed1988

Rectal carcinoid tumors. Report of two cases.

Two cases of rectal carcinoid tumors are reported. In the first case the endoscopic diagnosis was intramural rectal neoformation. At histology, rectal carcinoid tumor with infiltration of the muscularis mucosae was diagnosed. Abdominoperineal resection was performed. The patient is still living 3 years following surgery. In the second case, the endoscopic diagnosis was non-adenomatous polyp. Endoscopic polypectomy was performed. At histology, rectal carcinoid tumor was diagnosed. The patient is still living 2 years following surgery.

Carcinoid Tumor↗
PubMed1985

Crohn's disease of the esophagus. A case report.

A case of Crohn's disease localized in the inferior third of the esophagus with negative radiological evidence, positive endoscopic evidence, and aspecific signs of esophageal wall inflammation is reported. Evaluation of clinical remission of dysphagia and endoscopic features of the esophageal lesions following steroid therapy led to the diagnosis of Crohn's disease of the esophagus in the patient already operated on for a colonic localization. Data from literature are examined with emphasis on the difficulty of the diagnosis.

Adult↗
PubMed1983

[Endoscopic and bioptic diagnosis of primary gastric lymphomas: 33 personal cases].

The Authors have diagnosed by endoscopy and biopsy 33 primitive gastric lymphomas (6,7% of all malignant gastric tumors diagnosed over 6 years). Endoscopic observation alone diagnosed lymphoma in 63,6% of the cases. Exact diagnosis was made in all cases of polymorphic or multi-ulcerated lesions. The observation of a single ulcerated or ulcero-vegetative lesion (30,3%) suggested diagnosis of carcinoma. A false negative diagnosis of inflammatory pathology was made in 6,1% of the cases. Biopsy gave correct diagnosis in 69,7%. Highest percentage of positive biopsies was obtained in both single and multiple ulcerated lesions (88,2%), while infiltrating lesions provided positive biopsies in 50% of the cases. Endoscopy together with biopsy gave correct diagnosis in 90,9%. In fact, endoscopic diagnosis of lymphoma was confirmed after resection in 7 cases even if the individual biopsies showed superficial gastritis. The Authors believe that correct endoscopic study of primitive gastric lymphomas is based on knowledge of the various morphologies of the tumor and on a systematic performance of a large number of biopsies of both the lesions and surrounding mucosa.

Adult↗
PubMed1981

[Determination of lactic dehydrogenase isoenzymes in precancerous and cancerous gastric mucosa].

We have studied modifications of LDH isoenzymes pattern in normal human gastric mucosa as well as in adenocarcinoma and precancerous lesions of the stomac (gastritis and ulcer); samples from the injured and the surrounding non-injured area were examined, drawing up the isoenzymes, using Tris-buffer pH 7,4 at 4 degrees C and performing the determination within 1 h - because of the high chronolability of the fractions LDH and LDH by cellogol electrophoresis separation. We have always noticed - especially in samples from adenocarcinoma- a shifting toward the M chains, with a clear increase of the fractions LDH4 and LDH5; this has been noticed even in the surrounding non-injured area.

Adenocarcinoma↗
PubMed1981

Ultrastructural study of parietal cells before and after parietal cell vagotomy in patients with duodenal ulcer.

The records of 16 patients of a total of 402 who underwent parietal cell vagotomy without a drainage procedure for duodenal ulcer were reviewed. Biopsies of gastric mucosa were taken before the operation and six months, two years and three years postoperatively. Ultrastructural studies using electron microscopy detail the modifications of the parietal cells which are the main target of the vagal denervation procedure. The parietal cells are greatly modified within six months after parietal cell vagotomy with a significant reduction of the secretory surface of the cells and a sharp increase of tubulovesicular formations regain their preoperative morphologic appearance after two to three years but not their secretory capacity.

Adult↗
PubMed1980

Ampicillin-associated colitis. Case report.

A case of ampicillin-associated colitis is described. The authors stress the importance of emergency colonoscopy for the correct diagnosis and treatment of severe diarrhea and hemorrhage occurring during treatment with antibiotics.

Adult↗
PubMed1980

Gastric gastrinoma and diffuse G cell hyperplasia associated with chronic atrophic gastritis. Endoscopic detection and removal.

Chronic atrophic gastritis and a sessile polyp were diagnosed during gastroscopy of a patient with splenomegaly and portal hypertension. The polyp was removed endoscopically. Histologically, it proved to be an endocrine tumour, which was identified as gastrinoma by immunohistochemistry. Then, hypergastrinemia was found and gastrectomy was performed to ensure complete removal of the tumour. The surgical specimen showed G cell hyperplasia of the antro-pyloric mucosa and severe atrophic gastritis with scattered argyrophil micronodules in the corpus-fundus region. 3 years after this treatment the patient is well.

Adenoma, Islet Cell↗
PubMed1977

[Our experience in esophago-colonic plastic surgery for esophageal stenosis caused by caustics].

The Authors report their experience (16 cases) in esophago-colon plastic surgery for esophageal stenosis from caustics and emphasize the advantages presented by the colon as a substitute for the esophagus, as compared with the stomach and jejunum. Although the results were equally satisfactory irrespective of the selected segment of colon, the Authors indicate their present preference for the left colon because of some technical aspects making the operation easier and more reliable.

Adolescent↗
PubMed1975

[Experimental and clinical studies on the use of a new suture material: polyglycolic acid].

Experimental and clinical investigation of polyglycolic acid, a new synthetic suture material, is reported. Experimental work was done on single-layer intestinal sutures, while clinical employment of the material was extended to various general surgery operations. There were few signs of inflammation at the site of implant, indicating that the new material has a greater degree of inertness than chronic catgut, restulting in optimal tolerance on the part of the body.

Animals↗