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Biomedical subjects

G Savary

Publications and source records attributed to G Savary.

7 recordsLinked to original sources
PubMed2006

Effects of level of feed intake on pancreatic exocrine secretions during the early postweaning period in piglets.

The objective of this study was to determine the influence of the level of feed intake and a 2-d feed restriction period on the postweaning adaptation of pancreatic exocrine secretions. At 33 d of age, 18 piglets fitted with 2 permanent catheters (for pancreatic juice collection and reintroduction) were weaned and allocated to 1 of the following 2 dietary treatments for 5 d: restricted feed allocation (restricted) or gradually increasing feed allocation (control). Pancreatic juice was collected daily during both basal and prandial periods. The basal period was defined as the period from 1400 to 1700 h (i.e., 5 to 8 h after the morning meal), whereas the prandial period was defined as the period from 30 min before to 60 min after the morning meal (given at 0900). Digestive enzyme activities and antibacterial activity were determined. Pancreatic protein secretion was 44% less (P < 0.05) in restricted piglets than in control piglets during the basal period. Trypsin secretion was affected by feed-restriction of piglets. The meal did not affect protein and trypsin secretions in restricted piglets, whereas at d 3 postweaning, protein and trypsin secretions and trypsin specific activity in control piglets were 9-, 105-, and 25-fold greater (P < 0.001) during the first 30 min after the meal than before the meal. Lipase and amylase secretions were not affected by variations in feed intake. The secretion of antibacterial activity in restricted piglets was greater (P < 0.05) than that of control piglets only at d 5. The extended feed restriction period increased the basal secretion of antibacterial activity (P = 0.09) and postprandial secretion of amylase (P = 0.05). In conclusion, a low level of feed intake during the early postweaning period decreased pancreatic protein and trypsin secretions, whereas a 2-d feed restriction period enhanced secretions of amylase and antibacterial activity. In addition, our results indicate that during periods of dietary adaptation, such as at weaning, measurements of enzyme activities in the tissue do not accurately reflect the enzyme secretion.

Animal Feed↗
PubMed2001

INTACS inserts for treating keratoconus: one-year results.

OBJECTIVE: To evaluate the use of INTACS micro-thin prescription inserts (Kera Vision, Inc., Fremont, CA) for the treatment of keratoconus. DESIGN: Prospective, nonrandomized (self-controlled) comparative trial. PARTICIPANTS/INTERVENTION: Ten patients from our prospective clinical study who had completed 12 months of follow-up were evaluated. All patients had keratoconus with clear central corneas and were contact lens intolerant. After reviewing corneal pachymetry and topography of individual patients, INTACS inserts of 0.45-mm thickness were placed in the inferior cornea to lift the cone and INTACS of 0.25-mm thickness were inserted superiorly to counterbalance and flatten the overall anterior corneal surface. MAIN OUTCOME MEASURES: Differences between preoperative and postoperative uncorrected visual acuity, best spectacle-corrected visual acuity, manifest refraction, and keratometry values were statistically assessed. Changes in corneal ectasia were evaluated by reviewing corneotopographic maps. RESULTS: No intraoperative complications occurred in this series of patients. Spherical equivalent error and refractive astigmatism were reduced with INTACS inserts treatment. Postoperative month 12 uncorrected visual acuity (logarithm of the minimum angle of resolution [logMAR] mean, 0.35, standard deviation [SD], 0.16 [approximately 20/50, approximately 2 lines]) was significantly better than preoperative (logMAR mean, 1.05; SD, 0.33 [approximately 20/200, approximately 3 lines]; P <or=0.05). Average best spectacle-corrected visual acuity at postoperative month 12 was improved by approximately two lines compared with baseline (logMAR mean, 0.22; SD, 0.12 [approximately 20/32, approximately 1 line]; logMAR mean, 0.38; SD, 0.13 [approximately 20/50, approximately 1 line], respectively). Topographic corneal shape (size and height of the cone) was improved for all subjects after insert placement. CONCLUSIONS: INTACS micro-thin prescription inserts seem to provide a viable method for treating clear corneal keratoconus for patients who are contact lens intolerant. The corneal steepening and astigmatism associated with keratoconus were reduced, and visual acuity was improved with treatment in almost all eyes.

Adult↗
PubMed2000

Correcting keratoconus with intracorneal rings.

PURPOSE: To evaluate the potential of intrastromal corneal ring technology (Intacs, KeraVision) to correct keratoconus without central corneal scarring. SETTING: Department of Ophthalmology, Brest University Hospital, Brest, France. METHODS: In this prospective, noncomparative, interventional case series, Intacs segments were implanted in 10 keratoconic eyes with clear central corneas and contact lens intolerance after corneal pachymetry was checked. Segment thicknesses varied based on corneal topography analysis. RESULTS: No intraoperative complications occurred. The mean follow-up was 10.6 months. Postoperative results revealed a reduction in astigmatism and spherical correction and an increase in topographical regularity and increased uncorrected visual acuity. CONCLUSION: Intacs technology can reduce the corneal steepening and astigmatism associated with keratoconus.

Adult↗
PubMed1984

Hyperadrenergic syndrome in severe tetanus: extreme rise in catecholamines responsive to labetalol.

The hyperadrenergic syndrome that occurs in tetanus is characterised by hypertension, tachycardia, and increased systemic arteriolar resistance. A 74 year old man with tetanus was found to have very high catecholamine concentrations--as high as those in phaeochromocytoma--and the fluctuations in blood pressure and heart rate were measured to see whether they paralleled changes in the catecholamine values. A labetalol infusion of 0.25-1 mg/min gradually stabilised the cardiovascular disturbances and the patient recovered.

Adrenergic Fibers↗