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G Savettieri

Publications and source records attributed to G Savettieri.

At least 37 records · Page 2Linked to original sources
PubMed1986

Rat CNS neurons are not yet programmed to shorten their chromatin repeat length at the end of fetal neurogenesis.

Neurons from rat fetal cerebral hemispheres were grown in a synthetic medium (Maat medium), as previously described, for different periods of time. The repeat length of their chromatin was determined by micrococcal nuclease digestion and compared with that of neurons isolated from postnatal rat brain of corresponding ages. In contrast to the in vivo situation, we found that neurons, dissociated at the 16th gestational day and cultured in vitro, did not undergo the shortening of their chromatin repeat, thus indicating that, at the end of their mitotic cycles, they are not yet programmed to this event.

Aging↗
PubMed1986

A further study on the prevalence of multiple sclerosis in Sicily: Caltanissetta city.

The prevalence of probable multiple sclerosis (MS) in Caltanissetta city, Sicily, is at least 51 per 100,000. If possible multiple sclerosis patients are included, it is 54 per 100,000. This value is similar to that found in other cities in Sicily: Enna, Monreale and Agrigento. The high prevalence of multiple sclerosis in Caltanissetta confirms the previous data on Sicily and emphasises the importance of small population studies in the epidemiology of MS.

Adolescent↗
PubMed1985

Formulation of a novel synthetic medium for selectively culturing rat CNS neurons.

Dissociated cells from rat fetal cerebral hemispheres were grown in surface adhering culture using a novel synthetic medium (Maat medium) and compared with those grown either in the presence of serum or in the chemically defined medium described by Bottenstein and Sato. The addition of various compound combinations allowed us to lower insulin concentration to almost physiological levels. Maat medium improved the purity and longevity of neuronal cultures. The purity of neuronal cultures grown in different media was checked both by immunofluorescence and by the analysis of [3H]thymidine incorporation.

Animals↗
PubMed1984

Rat CNS cell culture. Enhancement of neuronal survival and delay of glial proliferation by serum from patients with multiple sclerosis. A morphological study.

The addition of serum from multiple sclerosis (MS) patients to the culture medium of dissociated cells from cerebral hemispheres of rat embryos caused a delay in glial proliferation and an enhancement of neuronal survival. Sera from normal individuals and patients with other neurological diseases failed to show this effect. These morphological observations are interpreted as the outcome of inhibition of in vitro gliogenesis.

Animals↗
PubMed1983

Selective culture of rat CNS neurons in a synthetic medium.

A Chemically Defined Medium is described which facilitates the survival of neurons in primary cultures of rat cerebral hemispheres. More than 90% of all cells were identified as neurons using neurofilament as a marker in an immunocytochemical assay. In contrast, serum-supplemented medium, by stimulating nonneuronal cell proliferation, hinders the survival of neurons in culture.

Animals↗
PubMed1977

Effects of denervation on the neuraminidase activity of slow and fast muscles of rabbits.

The presence in skeletal muscles of rabbits of neuraminidase activity on sialyl lactose was demonstrated. By comparing the specific activity of this enzyme in different control muscles, it was shown that it was 2.3 times higher in the slow than in the fast muscles. Seven days after denervation, we observed a significant increase of activity in fast muscle and a significant decrease of activity in slow muscle. These results, together with previous data, are in favour of the hypothesis that turnover of muscle glycoconjugates is under a type-specific neural control.

Animals↗
PubMed1977

[Foix-Chavany's syndrome: clinical and electrophysiological study of 1 atypical case (author's transl)].

An atypical case of "Foix-Chavany syndrome", is described. A definite diagnosis could be achieved through an electromyographic and reflessological investigation (jaw reflex, blink reflex, perioral reflex), when a poor clinical history was not helping towards a definite diagnostic conclusion. It is proposed that the diagnosis of "Foix-Chavany syndrome" should not be limited only to classical "facial diplegia of cortical origin" or to "facio-linguo-pharyngo-laryngo-masseter paralysis of cortico-subcortical origin". Considering the great clinical variability of a syndrome with a common anatomical substrate, it is proposed to use the eponym for all syndromes characterized by: 1) a motor deficit in the cephalic district with relative integrity of motor function of the limbs; 2) a dissociation between loss of voluntary motility and preservation of reflex and automatic motility.

Deglutition Disorders↗
PubMedDate not supplied

Ganglioside stimulation of neuronal maturation in vitro.

Neurons from fetal rat brain hemispheres cultured in synthetic medium were stimulated to aggregate into clusters and to send out neurites by the early addition of gangliosides. This stimulatory effect was limited at the beginning of the culture. In fact the ganglioside addition did not affect either the axonal sprouting or the survival time of the neurons.

Animals↗
PubMedDate not supplied

[Histopathogenetic aspects in a case of Fahr's disease (non arteriosclerotic calcinosis of the brain) (author's transl)].

The study of one case of non arteriosclerotic calcinosis of the brain (Fahr's Disease) gives an opportunity for a discussion on the main pathogenetic aspects of this syndrome. Some features of hypertrophy and hyperplasia of astrocytes contrast with the fair preservation of neurons. It is suggested that such condition should be considered as an "astroglial syndrome" in Seitelberg's terminology.

Adult↗