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Biomedical subjects

G Schley

Publications and source records attributed to G Schley.

At least 19 recordsLinked to original sources
PubMed2001

[Angioendotheliomatosis proliferans systematizata].

Angioendotheliomatosis proliferans systematisata comprises two different entities; a malignant and benign (reactive) form. The more common malignant form with a fatal prognosis should be termed intravascular or angiotropic lymphoma and is a multifocal systemic disease, which affects especially the small and middle-sized blood vessels of the skin and central nervous system. Reactive angioendotheliomatosis is a benign disease, often associated with an infectious disease (predominantly with subacute bacterial endocarditis). We report a 38-year-old woman with a reactive angioendotheliomatosis and a 68-year-old man diagnosed as having the rare T-cell type of intravascular lymphoma.

Adult↗
PubMed1976

[Oral contraceptives in prophylaxis of acute exacerbations of intermittent porphyria (author's transl)].

Out of 14 women with acute intermittent porphyria seven were treated for an average of five years with ovulation inhibitors. In another two cases a bilateral surgical oophorectomy and a radiotherapeutic castration were performed. Five untreated women formed the control group. In contrast to the control group there were no further acute exacerbations in the group treated with oral contraceptives. The two patients with oophorectomy and irradiation castration died following multiple acute exacerbations. In four of the women treated with oral contraceptives the development of persistent, and in some cases severe, arterial hypertension was observed. The pathogenesis cannot be explained.

Acute Disease↗
PubMed1976

[Acute intermittent porphyria: report on 17 patients with 49 attacks (author's transl)].

In 17 patients (15 women, 2 men) with acute intermittent porphyria in the incidence of 23 clinical symptoms during 49 attacks was calculated. The most frequent symptoms in percentage of attacks were: Red colour of the urine 100%, abdominal pain 92%, tachycardia 88%, hypertension 75%, vomiting 54%, peripheral neuropathy 50%. In 35% of acute attacks a transient normochromic, normocytic anemia developed which is probably due to a disturbance of heme synthesis. Oliguria was found in 25%, azotemia in 12.5% of attacks. 4 patients with an average of 5 preceding acute attacks showed a persistent reduction of renal function during the symptom-free interval, in contrast to 12 patients with an average of 1.7 previous attacks and normal renal function. During the observation period from 1960-1974 3 (= 18%) of the 17 patients died.

Acute Disease↗
PubMed1975

[Isolation of influenza virus "A/Hong Kong/1/68 (H3N2)" from liquor cerebrospinalis of patients with CNS involvement (author's transl)].

Liquor cerebrospinalis of eight patients with central nervous symptoms were tested for influenza virus during the influenza virus epidemic 1971/72. In three of these cases influenza virus (A/Hong Kong/1/68 (H3N2) was isolated from spinal fluid in the embryonated hen egg. These patients showed after influenza like prodromi meningo-encephalitis, encephalitis or paranoid psychosis. Possible pathomechanisms are discussed.

Adolescent↗
PubMed1975

[Influence of spontaneous collaterals on the fibrillation threshold of the heart following acute coronary occlusion].

Fibrillation threshold (FS) were determined in 27 mongrel dogs by direct electrical stimulation of the myocardium by 50 Hz AC impulses of 0.20-0.28 sec during the vulnerable period. The FS is the current which just suffices to produce ventricular fibrillation. Sinus rhythm was restored 10 sec after onset of ventricular fibrillation by defibrillation. Determinations of FS were carried out for each animal repeatedly before and 3 min after acute ligation of the circumflex ramus respectively the descendens ramus of the left coronary artery. Post mortem selective coronary angiography was performed in all cases and the extent of spontaneous collateral vessels was estimated by the rate of retrograde contrast radiography of the ligated coronary artery. The FS fell appreciably following acute ligation of both the circumflex ramus and the sescendens ramus. Beside the size of the ligated area (the circumflex ramus supplies a larger area of the myocardium in the dog than the ramus descendens) the extent of collateral supply was the determining factor for the reductions of the FS: Following coronary ligation of the circumflex ramus the FS fell on the average from 24.0 mA to 4.1 mA if no collateral vessels were detectable; in the animals with well developed collaterals the FS was reduced from 24.8 to only 14.1 mA. After acute occlusion of the descendens ramus the FS fell from 27.9 mA to 11.5 mA in the group with not sufficient collateral supply and from 31.2 mA to only 21.5 mA in the group with well developed collaterals. The comparison of the different decreases of the FS after coronary occlusion clearly shows that the influence of the in size differing ischemic areas on the decrease of the FS is particularly evident if no collateral vessels are existent. If collateral vessels are well developed this difference is not significant. These results demonstrate that the influence of well developed collaterals on the decrease of the FS after coronary occlusion exceeds the dependence on the size of the ischemic area.

Acute Disease↗