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Biomedical subjects

G Schuster

Publications and source records attributed to G Schuster.

10 recordsLinked to original sources

[Fissure contents in rodent molars].

The fissure contents in rodent molars were examined by means of a stereomicroscope and compared with those in caries-free human molars and premolars. As to colour, consistency and removableness, the fissure contents in the rodent molars were similar to those in human teeth. An orange substance as found in the fissures of human teeth was not detected in the fissures of rodent molars. This fact does not tell against the use of rodent molars as a study model for fissure contents.

Animals

Antiphytoviral activity of 2,4 dioxo hexahydro triazine.

Three treatments with 2,4 dioxo hexahydro triazine (DHT) significantly reduced the concentration of potato virus X (PVX) in systemically infected tobacco plants. In hypersensitive plants DHT caused a reduction in the number of local lesions produced by PVX. In systemic and hypersensitive hosts, treatment with DHT resulted in a more or less marked reduction in the concentration of, and in the number of local lesions caused by, potato virus Y (PVY), potato virus A (PVA), tobacco mosaic virus (TMV), and cucumber mosaic virus (CMV). Three days after treatment with DHT the incorporation of 32P into TMV RNA was significantly reduced, while that into host RNA was less affected.

Antiviral Agents

[Dioxohexahydrotriazine, a new synthetic antiphytoviral compound (author's transl)].

This paper reports the first results of studies made to determine the antiviral activity of dioxo hexahydro triazine, a newly developed antiphytoviral compound. After treatment with dioxo hexahydro triazine, the concentration of helical potato virus X in leaves of Nicotiana tabacum "Samsun" was found to be considerably reduced in both the serological test and local lesion test conducted on Nicotiana glutinosa at temperatures of 14 degrees C +/- 3 degrees C. In secondarily infected leaves, the reduction of the concentration of potato virus X in the range of from 1 mol/l to 10(-3) mol/l was so that it was no longer possible for viruses to be detected serologically. In vitro, however, dioxo hexahydro triazine, which was added to the inoculum, did not produce a significant change in the activity of the virion of potato virus X. Therefore, it is reasonable to assume that dioxo hexahydro triazine tends to affect replication steps of viruses. The use of dioxo hexahydro triazine also had the effect of greatly and highly significantly reducing the concentration of the isodiametric cucumber mosaic virus.

Antiviral Agents

[Structurally dependent effects of substituted thioureas on rna phage m 12 (author's transl)].

Using the agar diffusion method, thiourea as well as N-aryl-, N, N'-diaryl-, N-aryl-N'-alkyl-, N,N'-dialkyl-, and N-alkyl-substituted thiourea derivatives were examined for their effects on the system of Escherichia coli W 1665 F+/M 12. The compounds tested were found to produce more or less strongly inhibitive or promotive effects on the RNA phages and/or host bacteria. N-phenyl-N'-dibutyl thiourea, N-phenyl-N'-acetyl thiuorea, and N1,N1'-p-phenylene-bis-(N3-n-propyl thiourea) showed an intense inhibitory effect on M12. Quite obviously, the decisive intervention by these substances in the multiplication of viruses was by a replicative step subsequent to the adsorption of phages.

Coliphages

[Acute ischaemia after osteosynthesis of the proximal thigh (author's transl)].

In consequence of the increasing osteosynthetic treatment of bone fractures we draw the attention to iatrogenic blood vessel injuries. Primary location is the proximal thigh. Most important is the clinical diagnosis of an acute ischaemia of the operated limb. An arteriographic diagnosis is not necessary, but the operation site should be explored immediately. Prevention of intraoperative lesions of great vessels consists of exact anatomic reposition of the bone fragments, a subtile osteosynthesis whereas the osteosynthesis material should not extend the bone cortex. Exact haemostasis should be performed, avoiding extending ligations. Intraoperative as well as postoperative control of peripheral pulses should never be omitted.

Acute Disease

[Structurally dependent effects of substituted thioureas on the concentration of potato virus X in Nicotiana tabacum L. "Samsun" (author's transl)].

A study has been made to investigate the effects of N-alkyl- and aryl-substituted thioureas as well as N,N'-alkyl-alkyl-, alkyl-aryl-, and aryl-aryl-substituted thioureas on the multiplication of PVX in Nicotiana tabacum L. "Samsun". The virus concentrations of the treated plants were serologically determined and compared with these of untreated controls. The weak antiphytoviral effect of nonsubstituted thiourea remained virtually unchanged in N,N'-dimethyl thiourea, and in N,N,N'-trimethyl thiourea. A stronger antiphytoviral effect was observed for N-phenyl, N',N'-pentamethylene thiourea, as well as N-methyl thiourea. All other substitutions, especially those by longer-chain substituents or by a larger number of substituents, were not found to have an influence on viral multiplication.

Chemical Phenomena

[The clinical data of infected umbilical sinus].

We report the case of a female baby, three months of age, with anemia of chronic infection, hematuria and umbilical sinus. The patient did survive a sepsis and the extirpation of the umbilical sinus and died in a septic shock. Diagnosis and therapy of the anomalies of the umbilicus are discussed and a possible explanation for the hematuria is presented.

Anemia