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Biomedical subjects

G Sclare

Publications and source records attributed to G Sclare.

7 recordsLinked to original sources
PubMed1991

Malignancy in nonagenarians.

In a series of 143 necropsies on aged subjects, age range 90 to 100, 20 patients were found to have died of malignant disease and a further 16 patients had a total of 20 non-fatal malignant tumours. The rate of clinical recognition was lower than would be expected in other age groups. Adenocarcinomas of the digestive system predominated in the fatal group. This study confirms previous reports of a high incidence of non-fatal tumours and a diminished tendency to metastasis in both fatal and non-fatal cases. These features are not thought to imply diminished aggressiveness of malignant tumours in extreme old age, since analysis of individual cases provided other explanations such as death from unrecognised local complications of the tumour or the intervention of an unrelated cause of death. There was, however, an unexpectedly high number of cases of long survival after excision of a malignant tumour, including a case of spontaneous regression.

Aged↗
PubMed1988

Malignant mesothelioma of the tunica vaginalis testis: a case report.

We report a case of malignant mesothelioma of the testicular tunica vaginalis. A preceding hydrocele showed mesothelial hyperplasia of its lining. The tumor was treated surgically as well as with a combination of radiotherapy and chemotherapy but it progressed, resulting in death within 21 months from the diagnosis. The relationship of the tumor to mesothelial hyperplasia and to previous exposure to asbestos is discussed.

Humans↗
PubMed1981

Pneumoconiosis of shale miners.

Four patients are described in whom pneumoconiosis was diagnosed towards the end of a lifetime's work in shale mines. All developed complicated pneumoconiosis, diagnosed in two cases at necropsy, in one by lobectomy, and in one radiologically. Two of the patients were found at necropsy also to have peripheral squamous lung cancer. The clinical and histological features of the disease resembled the pneumoconioses of coalminers and kaolin workers and the lungs of three of the patients were shown to contain dust composed predominantly of kaolinite, mica, and silica. Shale miners' complicated pneumoconiosis has not previously been described. Although the British shale industry is now defunct, oil production from shale is expanding in other countries, notably the USA. It is suggested that control should be exercised over dust exposure levels in this industry and that epidemiological studies should be carried out to quantify the risks of both pneumoconiosis and bronchial carcinoma.

Aged↗
PubMed1980

Carcinoma associated with myelomeningocele.

A case is described of an epidermal carcinoma developing at the site of a myelomeningocele in a 50-year-old man. As in the three other cases of this condition which have been reported, the patient died, which reinforces the suggestion that possible malignant changes, though rare, should be taken into account when considering closure of such dysraphic lesions during childhood.

Carcinoma, Squamous Cell↗