The brain distribution of old and new antiepileptic drugs.
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Animals↗
Biomedical subjects
G Sechi
Publications and source records attributed to G Sechi.
The flight-of-colors test in multiple sclerosis.
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Adolescent↗
Beneficial effect of fluoxetine in a case of sporadic hyperekplexia.
We studied a 67-year-old woman with a sporadic form of hyperekplexia, who experienced 8-10 excessive startle responses to unexpected stimuli per month. Therapy with fluoxetine had a definite beneficial effect. This finding supports the hypothesis that serotonergic mechanisms play a role in this disorder.
Aged↗
Myocardial infarction complicating status epilepticus.
No documentation is available for myocardial infarction complicating status epilepticus. A 31-year-old man developed an acute inferolateral myocardial infarction during repetitive epileptic seizures. A cineangiographic study performed 6 months later revealed normal coronary arteries and an apical aneurysm in the left ventricle. The main pathogenetic mechanisms involved and a therapeutic possibility are discussed.
Adult↗
Effects of ketamine anesthesia on phenytoin biodisposition.
After oral administration (10% suspension in arabic gum, at 500 mg/kg), total phenytoin (PHT) concentrations were measured in the blood and brain of rats anesthetized with ketamine (60 mg/kg, intraperitoneally i.p.) and in a control group that received only PHT. The concentration of PHT in blood and brain was significantly higher in the ketamine than in the control group. At 1, 1.5, 2, and 3 h, increased brain PHT reflected increased blood concentrations. At all times, the plasma protein binding of PHT was similar in both groups. After intravenous (i.v.) administration, instead, at 10 mg/kg, total PHT concentrations were similar in rats anesthetized with ketamine (60 mg/kg, i.p.) and in a control group that received only PHT under mild ether anesthesia. Thus, the main factor involved with the altered PHT biodisposition caused by ketamine anesthesia appears to be increased absorption of the drug.
Administration, Oral↗