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Biomedical subjects

G Seng

Publications and source records attributed to G Seng.

8 recordsLinked to original sources
PubMed1989

Metabolic effects of a single administration of growth hormone on lipid and carbohydrate metabolism in normal-weight and obese subjects.

The effects on lipid metabolism of a single intramuscular dose of SR 29001 (0.15 U/kg body wt), a biosynthetic human growth hormone (hGH), were explored in a double-blind randomized crossover vs a placebo study of six normal-weight and six obese subjects (Quetelet Index greater than 120%). Circulating hGH concentrations reached means of 35 and 28 ng/mL in the normal-weight and obese subjects, respectively. Free fatty acids increased in both groups (p less than 0.05); increases in beta-hydroxybutyrate and acetoacetate concentrations were more moderate (NS). Plasma glucose increased significantly despite a significant increase in insulin (p less than 0.002). The lipolytic effect persisted after a standardized 950-kcal meal eaten 5 h after hGH administration. A delayed increase in somatomedin-C and decreases in blood urea and total cholesterol were also observed (p less than 0.05). Despite increased insulin secretion, biosynthetic hGH produced a significant increase of lipolysis in both groups, which was only partially suppressed by food.

3-Hydroxybutyric Acid↗
PubMed1988

[Endometrium and diabetes].

Endometrium play a fundamental role during the 12 days following conception: its metabolic activity is responsible for the nutrition of the embryo. This nutritive function can be reduced in the presence of maternal diabetes mellitus, with a clinical incidence: unexplained sterility, spontaneous abortion and fetal malformations are more frequent in the presence of poorly controlled maternal diabetes mellitus. These abnormalities are directly correlated to the degree of hyperglycemia and reflect changes in the metabolic activity of the endometrium. Our biochemical study demonstrate that enzymatic activities are responsible, in human endometrium, for glucogene storage in the perovulatory period and energy production during the post ovulatory period; diabetes mellitus is responsible, at least in animal endometriums, for a reduced ability of glucogen storage and a reduced activity of glycolysis enzymes and of glucose 6 phosphate deshydrogenase.

Animals↗
PubMed1983

Circular dichroism studies in the near UV of ligand binding to chicken liver dihydrofolate reductase.

Circular dichroism spectra in the near UV (250-400 nm) were recorded for chicken liver dihydrofolate reductase and its complexes with substrates, inhibitor methotrexate, and cofactor NADPH. The spectra obtained with methotrexate are very like those published for bacterial dihydrofolate reductases. Thus we suggest that the conformations of methotrexate at the active site of the chicken liver enzyme and that of the enzyme from Lactobacillus casei which has been described extensively in X-ray studies show a great similarity. The same similarity does not hold in the case of the substrate dihydrofolate where the C.D. spectra of binary complexes obtained with enzymes from different sources are different.

Animals↗