Biomedical subjects
G Silberkuhl
Publications and source records attributed to G Silberkuhl.
Circadian variation of aldosterone urinary excretion in idiopathic hypertension.
Daily variations of the urinary aldosterone excretion have been studied in 8 hypertensive and in 4 normotensive women. The examined subjects did not receive any drug for at least two weeks before the study and were under the same standardized life-conditions. The urine samples were collected every 3 h for two consecutive days. Population mean cosinor analysis by Halberg did not yield a statistically significant rhythm of aldosterone urinary excretion in the hypertensive group. Further investigation of the temporal structure of the renin-angiotensin-aldosterone system is therefore necessary.
Electrolyte urinary excretion in hypertensive conditions.
Daily variations of electrolyte excretion have been studied in 8 hypertensive and in 4 normotensive women by collecting urine samples every 3 h for a 48-h span. After noticing the absence of a statistically significant circadian rhythm in the hypertensive group, the Authors suggest the hypothesis that a prolonged treatment with diuretic drugs may cause kidney troubles and suppress the circadian rhythm of urinary electrolyte excretion. The Authors conclude affirming that this hypothesis needs further investigation to allow a better chronotherapy of the hypertensive disease in the future.
Essential hypertension, chronobiological study of the circadian variations in urinary excretion of free catecholamines.
Arterial blood pressure and urinary free catecholamine excretion of 8 hypertensive and 4 normotensive women have been evaluated by 3-h interval samples for 2 consecutive days. After noticing the effects of sleep on the arterial blood pressure and on the daily variation of urinary free catecholamine excretion, the authors examined the possible different role of the adrenergic system in hypertensive subjects.