Biomedical subjects
Publications and source records attributed to G Skromne-Kadlubik.
Using antiestrogen labelled with iodine-131 we proved the useful as diagnostic and therapeutic tools to identified hormone dependent cancers in breast with very encorageous results in 7 cases of human cancer. The method was simple and safe and similar methods for scanning of prostate tumors dependent are in current research in our laboratory and will be object of other communications.
Using thioglucose labeled with goid-1 98 (Au-1 98) at doses of 2OµCi per patient, we took specific scans of the hypothalamic satiety centers in 50 normal volunteers and in 50 obesity patients, due to the ability of the hypothalamic satiety centers to take up thioglucose in their glucostat receptors. From the 50 obesity patients, two were classified as having hypothalamic obesity. The rest were controlled with serial scans in combination with nutritional, surgery and clinical control of obesity, with satisfactory results for the 'obesity team'.
Five hundred patients with cysticercosis of the nervous system were evaluated by scanning that used anti-Cysticercus antibodies labeled with indium 113. The same antibodies, labeled with iodine 131, were used for radioimmunotreatment. Ninety-six percent of the patients had good or excellent results, whereas only 4% had poor results. None of the patients showed intolerance or radiotoxicity during three months of clinical and laboratory follow-up. The diagnosis, treatment, and prognosis of cysticercosis of the nervous system are dramatically changing, due to the development of anti-Cysticercus antibodies labeled with radionuclides.
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The nerve growth factor is a polypeptide isolated from the salivary glands of certain laboratory animals. Its greatest physiological effect is on the autonomic nervous system. When antiserum against this nerve growth factor was injected in newborn animals nearly total destruction of the sympathetic ganglia was noted, a procedure known as immunosympathectomy. The anti-nerve growth factor labeled with 131iodine was injected in rats to determine organ distribution at different intervals (2, 4, 6, 8 and 24 hours). A selective concentration was obtained in the sympathetic ganglia and adrenal medulla (adrenal ganglia) 4 hours after the intravenous injection of 50 muCi. 131Iodine anti-nerve growth factor, with a specific activity of 0.001 gm. per mCi., permitted scanning of this structure for the first time. No intolerance or radiotoxicity has been observed in the animals and the results are encouraging. Radioimmunoscanning of the sympathetic ganglia and adrenal medulla in the human and radioimmunosympathectomy of the structures are being studied currently and will be subjects of future communications.
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Using a 64Cu complex, we obtained human basal ganglia scans in three normal volunteers and in one patient with Wilson's disease with an oral dose of 1 mCi. The method with this new radioactive compound was simple and safe and the results were very encouraging.
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Explore the source record for details and available documents.
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Using antibodies against Toxoplasma gondii labelled with indium-113 metaestable we obtained scan of rats infested with this disease in a simple and harmless way. Also using the same antibodies, but labelled with iodine-131, we destroyed by radiolysis the toxoplasmas of experimental animals with the Medial Lethal Dose obtained "in vitro" experiments. The experimental results are very encouraging and their use in human beings are in currently research in our laboratory and will be the object of a future communication.
The "nerve growth factor" is a polipeptide isolated from salivary glands of some mammals. Its main physiological effect is on the autonomic nervous system. The injection of antiserum in newborn animals leads to nearly total destruction of the sympathetic ganglia (immunosympathectomy). Anti-nerve growth factor labelled with Iodine-131 was injected in rats for the determination of organ distribution at different times (2,4,6,8 and 24 hours). A selective concentration in the adrenal medulla was obtained at 4 hrs. after intravenous administration of 50 uCi of anti-nerve growth factor with an specific activity of 0.001 g/mCi that permits, for the first time, the scan of the adrenal medulla. No intolerance or radiotoxicity was observed in the animals during a six-month follow-up period. The results are very encoragin, and the application of this new method in humans is at present under study.
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Using the colorant proteic complex labell with Tc-99 m. we visualize--by the first time--the carotideal glomus in the human in 6 volunteers and one patient with tumor. The results are very encorageous: the method was simple and safe (one single dose endovenously) and hardless (no radiotoxicity presents in 3 months of clinical and laboratory controls) and there is a good visualization by scan of carotideal bodies "in vivo", in human being. We think this new method and labell compound could be useful in research and medical diagnoses.