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Biomedical subjects

G Smolin

Publications and source records attributed to G Smolin.

At least 37 records · Page 2Linked to original sources
PubMed1979

The effect of indoxole on the corneal immunologic response.

To study the effect of locally administered indoxole (with polysorbate 80) on the inflammatory and immunologic responses, we made unilateral intracorneal injections of rabbit eyes with bovine gamma globulin (BGG). The indoxole was injected subconjunctivally one day before, and 1, 2, 3, and 5 days after the BGG injection. The homolateral lymph nodes, uveal tracts, and corneas of rabbits killed on postinjection days 6 and 12 were tested for antibody-forming cells (AFC) by a modification of the Jerne plaque technique. On day 6 the indoxole-treated eyes were more inflamed and had a greater number of AFC in the tested tissues than the control eyes, but in neither of these respects was there any essential difference between the treated and control eyes on day 12. The possible mechanisms by which indoxole achieved its effect were explored.

Animals↗
PubMed1978

Treatment of herpes simplex keratitis with levamisole.

A model of chronic herpetic keratitis was developed by injecting rabbits subconjunctivally with a corticosteroid. A levamisole hydrochloride-treated group of these rabbits developed milder, more rapidly healing epithelial lesions than an untreated group. Although most of the untreated rabbits developed stromal disease, almost all of the lesions in the levamisole-treated animals were limited to the epithelium.

Animals↗
PubMed1978

The treatment of herpetic reinfection with levamisole.

The effect of levamisole on both clinical disease and virus recovery was studied in rabbits that were first infected with herpes simplex virus in one eye and then reinfected 14 days later by inoculation of the second eye. Reinfected rabbits treated with levamisole before reinfection developed significantly milder and smaller lesions than untreated controls. Virus recovery from the corneas was also less in the levamisole-treated animals than in the untreated controls.

Animals↗
PubMed1978

In vitro and in vivo effect of PC 904, a new broad-spectrum penicillin, on ocular strains of Pseudomonas aeruginosa.

The in vitro and in vivo activities of PC 904 were tested against Pseudomonas aeruginosa isolated from infected eyes and were compared with carbenicillin and gentamicin. By the microtiter plate method, we tested 30 strains of P. aeruginosa in vitro; PC 904 was very active against 29, but one strain was resistant. In a comparative study, PC 904 was more active than carbenicillin but less active than gentamicin. In vivo tests were conducted on rabbit corneas infected with a strain of P aeruginosa isolated in El Salvador. At moderate and high dosage levels, PC 904'S efficacy was comparable to carbenicillin's but much less than gentamicin's. When tested for ocular toxicity, the subconjunctival administration of PC 904 was well tolerated. The drug's greater activity in vitro than in vivo was probably due to its high serum-binding capacity.

Ampicillin↗
PubMed1978

Use of anti-inflammatory agents in destructive corneal disease.

The use of anti-inflammatory agents is important in the treatment of destructive corneal disease. The basic principles of the action of corticosteroids and prostaglandin inhibitors, and the application of these agents to various experimental and clinical situations, are presented. The corticosteroids are the most effective of all the anti-inflammatory agents but have many unfortunate side-effects. The prostaglandin inhibitors and other agents have fewer side-effects, but are less effective.

Adrenal Cortex Hormones↗
PubMed1977

Staphylococcal blepharitis.

A detailed discussion of various aspects of staphylococcal blepharitis is presented. These include epidemiology, pathogenesis and immunity, microbiologic characteristics, clinical signs, associated systemic diseases, differential diagnosis, and treatment.

Anti-Bacterial Agents↗
PubMed1977

Quantitative antibiotic sensitivity determinations of Staphylococcus aureus isolated from eye cultures.

The sensitivities of 108 strains of Staphylococcus aureus, isolated from patients with a variety of ocular conditions, were tested quantitatively against nine antibiotics by means of a microtiter broth-dilution method. Of the nine antibiotics, cephalothin sodium had the lowest (and therefore the best) minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC). The MBC and MIC of gentamicin sulfate were very close to those of cephalothin. The MBCs and MICs of erythromycin, ampicillin sodium, penicillin, tetracycline, methicillin sodium, and carbenicillin disodium were moderately good. Chloramphenicol had the poorest response.

Anti-Bacterial Agents↗
PubMed1977

Ticarcillin in the treatment of experimental pseudomonas keratitis.

In rabbits with experimental Pseudomonas aeruginosa keratitis the subconjunctival administration of either ticarcillin or gentamicin significantly ameliorated the keratitis and reduced the number of organisms to be found in the cornea. The use of these drugs in combination had an additive effect in vitro studies and a significantly more beneficial effect on the clinical disease than the use of either drug alone.

Animals↗
PubMed1977

Effect of local antilymphocyte serum on antibody forming cells.

Locally administered antilymphocyte serum was irritating to the eye and failed to alter the production of antibody-forming cells in the homolateral lymph nodes, corneas, and uveal tracts of rabbits that had received intracorneal injections of bovine gamma globulin.

Animals↗
PubMed1977

Effect of systemic corticosteroids on antibody-forming cells in the eye and draining lymph nodes.

After the intracorneal injection of rabbit eyes with bovine gamma globulin, a systemically administered corticosteroid resulted in the following changes: (1) a reduction in the number of antibody-forming cells in the homolateral uveal tract and cornea; (2) a reduction in the ocular inflammatory response; and (3) a reduction in the number of antibody-forming cells in the draining lymph nodes, if high doses of corticosteroid were given.

Animals↗
PubMed1976

Treatment of vaccinial keratitis with vidarabine.

Vaccinial epithelial keratitis was produced in rabbits. When the therapeutic effect of vidarabine on the experimentally-induced disease was evaluated and compared to the effect of idoxuridine, vidarabine was found to be highly effective, substantially more effective than idoxuridine, and nontoxic to the eye.

Animals↗
PubMed1976

Indomethacin and the corneal immune response.

To study the effect of treating rabbits with a locally administered noncorticosteroid anti-inflammatory drug, we gave 26 rabbits unilateral subconjunctival injections of 15 mg of indomethacin suspension daily for 16 days, starting one day before the intracorneal injection of the same eye with bovine gamma globulin. We graded the eyes clinically and killed groups of rabbits on postimmunization days 6, 9, 12, and 15. We determined the number of antibody-forming cells in the homolateral cervical lymph nodes, corneas, and uveal tracts and tested the sera, aqueous humor, and vitreous humor for antibodies. Indomethacin-treated eyes showed significantly less inflammatory response, and an insignificantly greater number of antibody-forming cells, than the controls.

Animals↗
PubMed1976

Proteus species isolated from human eyes.

Of 34 species of Proteus isolated from human eyes, 29 (85%) were P. mirabilis and five (15%) were P. morganii. In vitro antibiotic sensitivity studies showed that gentamicin best controlled both P. mirabilis and P. morganii of all the antibiotics tested. In vivo tests on experimental Proteus infections of rabbit coreas, treated with gentamicin and tobramycin, yielded comparable clinical results, but gentamicin was more effective in eliminating the organism from the experimental lesions.

Animals↗