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Biomedical subjects

G Spelger

Publications and source records attributed to G Spelger.

11 recordsLinked to original sources
PubMed1981

[Ultrasonics in the differential diagnosis of space-occupying lesions of the kidney in children].

During the last few years the coordination of ultrasound, radiology and urologic surgery led to the diagnosis and treatment of numerous diseases of the kidney. From 1976 till the beginning of 1979 we were able to diagnose 50 expanding retroperitoneal processes. These were hydronephroses, malignant tumors and enlargement of the kidney due to inflammatory affections ensuing nephrolithiasis as well as urosepsis and shock. The fact that sonography is a harmless, non invasive, simple and often repeatable examination is the most important advantage. Provided that ultrasound diagnosing is performed by an experienced person, there is a good correlation to the common x-ray methods and specially recommended for postoperative controls.

Child↗
PubMed1980

[Diagnosis of cholestasis in acute viral hepatitis in childhood (author's transl)].

Over a period of three years all children with acute viral hepatitis (n = 167) were examined for the presence of the abnormal lipoprotein X(LPX). Positive results could be found in 96% of patients with hepatitis A and in 82% of hepatitis B. A good correlation of LPX was ascertained with cholesterol, triglycerides, phospholipids, bilirubin, gamma-glutamyl transferase, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and immunoglobulin M. Control after 29 days in hepatitis A and 46 days in hepatitis B showed absence of LPX and normal pattern of lipoprotein-electrophoresis. Enzyme activities were slightly elevated, lipids and immunoglobulin M remained above upper normal range. In acute phase of viral hepatitis lipoprotein X is the most specific test in determining the presence of cholestasis, but in views on course of disease serum-lipids and immunoglobulin M have a similar sensitivity like enzyme patterns.

Adolescent↗
PubMed1980

[Cardiac parameters of the newborn after tocolysis (author's transl)].

Since 1971 premature labor has been treated with Fenoterol and Verapamil in the Department of Obstetrics and Gynecology of the University in Mannheim. In animal experiments as well as in the isolated fetal cardiac muscle elective myocardial necroses were observed following stimulation with beta-sympathomimetics. These lesions are prevented by additional application of Ca++-antagonists. Fenoterol and Verapamil are capable of passing through the placenta. To evaluate the question whether a possible cardiac lesion of the infant is caused by tocolysis, 31 newborns of mothers after tocolysis were compared to a group of 19 infants without tocolysis. At the first day of life as well as at the age of 2 and 4 weeks ECG was registered, and the serum electrolytes K+, Ca++ and Mg++ were determined. At day 1 and day 4 as well as during the 2nd and 5th week CK and CK-MB were measured, and during the 2nd week the size of heart was registered. We were unable to demonstrate pathological cardiac findings in newborns following tocolysis which were related to the preceding medication.

Calcium↗
PubMed1977

[Dubowitz syndrome with immunodeficiency and solid malignant tumor in two siblings (author's transl)].

The main features of Dubowiz syndrome are bird headed dwarfism and a typical facial configuration. Including two own patients 13 cases among 8 siblings are known in the literature. Two own cases of Dubowitz syndrome in two sisters are described, one of them with hypogammaglobulinemia and neuroblastoma, the other one with complete Ig A deficiency and malignant lymphoma. A propable relationship between immundeficiency and malignancies is discussed. Until 1973 151 malignant tumors with primary immundeficiency had been registrated. This paper is the first description of two cases of Dubowitz syndrome with immunodeficiency and malignant neoplasms.

Agammaglobulinemia↗
PubMed1975

[Hazards of heart catheterization and angiocardiography in the first year of life. A review of 1366 examinations].

1366 infants in the first year of life had cardiac catheterisation with or without angiocardiography in our Department of Cardiology between 1963 and 1973. The overally mortality in the first 24 hrs after the cardiac catheterisation for the first year of life was 1.83%. The subdivision of the first month of life reveals the high mortality rate of the first two weeks of life with the highest percentage of 18.9% in the first week of life and with 10.7% in the second week of life. After that time the mortality is significantly decreasing, but still amounts to 7.6% in the first month of life. There had been no death after the seventh month of life. 14 of the 24 infants died without a specific event in increasing heartfailure and/or acidosis. In the other 10 cases death was due either to the manipulation of the catheter (partial-perforation or perforation), to the angiocardiogram (subsequent asystole) or to the position of the catheter with subsequent intramural injection of contrast material.The best correlation was between the mortality and the severity of the underlying cardiac malformation. Further complications which did lead to death 24 hrs following cardiac catheterisation are described. Our results are compared with those of other authors. The reasons of various complications are discussed. Cardiac catheterisation and angiocardiography as early as possible is necessary because palliative procedures and corrective surgery can be initiated immediately. But it is important in the very sick infant to shorten the procedure as much as possible and to keep angiographic injections at a minimum.

Acidosis, Respiratory↗
PubMed1975

[Pre- and postoperative examinations in congential aortic stenoses].

70 patients with congenital aortic stenosis had been operated upon between the age of 7 months and 23 years (average 8 years). For evaluation of the surgical result recatheterization and angiocardiography had been carried out on all patients between 1 and 12 years after operation (mean 7 years). The pre- and postoperative catheter findings, angiocardiograms, ECG, heart-size and clinical findings were analysed and compared with each other. In 2/3 of the cases the operative results could be defined as good or satisfactory. In the last third the operative results had been poor and a reoperation unavoidable. In half of the cases the poor results had been due to a significant residual aortic stenosis and in the other half it was due to massive aortic regurgitation. The prognosis and the indication to operation had been discussed.

Adolescent↗