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Biomedical subjects

G Spring

Publications and source records attributed to G Spring.

10 recordsLinked to original sources
PubMed1996

Instrumental and perceptual evidence for tracheoesophageal speech.

With 8 men, two methods of alaryngeal speech production, tracheoe-sophageal and electrolaryngeal, were compared on perceptual and acoustic measures of speech intelligibility. Measures consistently identified the tracheoesophageal speech as superior to electrolaryngeal speech.

Aged↗
PubMed1983

[Effect of thiopental anesthesia on plasma renin, adrenaline and noradrenaline in neurosurgical operations with induced hypotension].

Excessive postoperative blood pressure reactions following surgery of cerebral aneurysms using sodium nitroprusside--induced hypotension can be avoided, if barbiturate-fentanyl-anaesthesia is employed instead of neuroleptanalgesia. Plasma renin activity (PRA), plasma concentration of adrenaline and noradrenaline were determined in 13 patients, undergoing surgery of cerebral aneurysms with induced hypotension (group I) and in 15 patients, who were operated on for brain tumors without hypotension (group II). The PRA was not increased in group II. The blood pressure was normal. In group I the PRA was significantly higher during and after the operation. In both groups adrenaline was not increased significantly. The noradrenaline concentration showed a significant increase in both groups, indicating a peripheral sympathetic stimulation. It is supposed that thiopentone inhibits the depletion of adrenaline and reduces the effect of increased PRA.

Adult↗
PubMed1981

New data on lithium and haloperidol incompatibility.

The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia. This case is similar to four other cases described in the literature and to the neuroleptic malignant syndrome. The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine. Possible mechanisms and preventive measures are discussed.

Antipsychotic Agents↗
PubMed1980

[Postoperative reactions of blood pressure after neurosurgical operations in deliberate hypotension (author's transl)].

29 patients were operated on cerebral aneurysms and arterio-venous malformations in hypotension induced by sodium nitroprusside, nitroglycerin or a combination of the two substances. The postoperative blood pressure levels were increased to 20--40% compared to the preoperative values. This obvious rebound-effect persisted for several hours. The dangers of postoperative hypertension are demonstrated. The possible pathogenetic factors are discussed.

Adolescent↗
PubMedDate not supplied

Prescribing patterns of antimicrobial agents in private practice in Umtata, Eastern Cape, South Africa.

OBJECTIVE: To describe the prescription patterns of antimicrobial drugs in the private sector in Umtata. DESIGN: Descriptive, retrospective study. SETTING: Umtata Pharmacy, Umtata (a town in the Eastern Cape). MAIN OUTCOME MEASURES: Prescription patterns and quality of prescription indicators. METHODS: Retrospective analysis of all prescriptions for antimicrobial drugs between 1 January and 31 December 2000, noting the method of payment, number of drugs, use of generic or brand name, and also whether or not the following were stated: diagnosis, dose, dosage form, dosing interval and duration of treatment. RESULTS: There were 2352 prescriptions, of which 57.7% were paid through medical aid; 41.7% by cash, while 0.6% of the prescriptions had no form of payment stated. Only 10.4% of prescriptions used generic names exclusively; 83.2% used brand names alone and 6.4% had both generic and brand names. The form of payment apparently influenced the number of items per prescription, with the average number for medical aid prescriptions higher than for those paid for in cash (2.71 vs. 2.11; p < 0.001). Of the prescriptions 12.5% had five or more drugs. The diagnosis was not stated in 94.3% of prescriptions, the dose and duration of treatment were not properly stated in 53.3% and 59.6% of prescriptions respectively. The dosage forms and dosing intervals were stated in 99% and 85% of prescriptions, respectively. The most commonly prescribed antimicrobials were amoxycillin, metronidazole and ketoconazole. CONCLUSION: The low rate of generic prescribing and the incomplete nature of many prescriptions are a cause for concern. Their cost implications and possible effect on the effective use of antimicrobial agents are discussed.

Anti-Bacterial Agents↗