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Biomedical subjects

G St Jean

Publications and source records attributed to G St Jean.

At least 19 recordsLinked to original sources
PubMed1997

Intussusception in cattle: 336 cases (1964-1993).

OBJECTIVE: To evaluate risk factors and to describe clinical and laboratory findings, surgical management, and postoperative outcome for cattle with intussusception. DESIGN: Hospital-based, case-control epidemiologic study and retrospective case series. SAMPLE POPULATION: Medical records of cattle admitted to 17 veterinary medical teaching hospitals in North America. PROCEDURE: Epidemiologic analysis of demographic data and detailed analysis of medical records for selected cattle. RESULTS: 336 cattle with intussusception were identified, 281 had small intestinal, 7 had ileocolic, 12 had cecocolic, and 36 had colocolic intussusceptions. Sex and season were not significantly associated with cattle developing intussusception, whereas calves < 2 months old were at greater risk of developing small intestinal intussusception than older cattle. Analysis of medical records of 57 cattle with intussusception revealed that these cattle were mildly hyponatremic, hypochloremic, hypocalcemic, azotemic, and hyperglycemic. Right flank laparotomy with a cow in a standing position, followed by intestinal resection and end-to-end anastomosis was the most common means of surgical correction. Overall survival rate (20/57; 35%) and postoperative survival rate (20/46; 43%) for cattle with intussusception were much lower than previously reported. CLINICAL IMPLICATIONS: Although rare in cattle, intussusception was most common in calves < 2 months old. Survival rate for cattle treated for intussusception was low (< 50%).

Age Factors↗
PubMed1997

Surgery of the respiratory system.

Diseases affecting the respiratory tract are common in cattle; however, surgery required for treatment of these diseases is infrequent. Therefore, veterinarians may be reluctant to perform these surgical procedures. Familiarity with the variety and complexity involved in various surgical procedures should reduce this anxiety. When used, surgery of the respiratory tract can offer significant benefit to the patient and profitable returns to the owner.

Animals↗
PubMed1997

Effect of amino acid supplementation on whole-body protein turnover in Holstein steers.

We used the [15N]glycine single-dose urea end-product technique to measure whole-body protein turnover in six Holstein steers (250 +/- 18 kg). Steers were implanted with Revalor-S and continuously infused abomasally with water (4 L/d) or amino acids (AA; in 4 L/d water) in a crossover experiment (two 14-d periods). The AA infusion contained the following (g/d): lysine (5.3), methionine (3.3), threonine (3.2), tryptophan (1.0), histidine (2.1), and arginine (5.5). Steers were fed a diet containing 85% rolled corn, 10% prairie hay, and 1.1% urea (DM basis) at 2.16% of body weight. Nitrogen retention tended (P = .15) to increase with AA infusion, from 27.9 to 32.9 g N/d. Amino acid infusion numerically increased whole-body protein turnover from 168.6 to 183.2 g N/d, protein synthesis from 152.6 to 169.3 g N/ d, and protein degradation from 124.7 to 136.4 g N/d. Enhanced protein accretion may have resulted from a larger increase in protein synthesis than in degradation. The tendency for increased N retention is interpreted to suggest that the implanted, lightweight Holstein steers fed a corn-urea diet in our study were able to respond to AA supplementation, suggesting that at least one of the infused AA was limiting in the basal diet. Protein turnover data suggest that cattle, like other animals, may increase protein synthesis and protein degradation in response to supplementation with limiting AA. The [15N]glycine single-dose urea end-product technique for measuring whole-body protein turnover in cattle may be useful.

Amino Acids↗
PubMed1997

Effect of increasing proportion of supplemental nitrogen from urea on intake and utilization of low-quality, tallgrass-prairie forage by beef steers.

Five Angus x Hereford steers with ruminal and duodenal fistulas were used in a 5 x 5 Latin square to determine effects of increasing the proportion of urea in supplemental degradable intake protein (DIP) on intake, fermentation, and digestion. Steers had ad libitum access to low-quality, tallgrass-prairie forage (2.4% CP, 76% NDF). Supplemental DIP (380 g/d) was from sodium caseinate and(or) urea and was balanced with cornstarch to provide a final supplement (approximately 939 g DM/d) that contained 40% CP. The percentages of supplemental DIP from urea were 0, 25, 50, 75, and 100%. Intake of forage OM was not affected (P > or = .30) by urea level. Ruminal and total tract digestibilities of OM and NDF generally responded in a quadratic manner (P < or = .09) to increasing urea, with the lowest values observed at the highest urea level. As a result, digestible OM intake (DOMI) declined (linear, P = .03) with increasing proportions of urea and tended (quadratic, P = .14) to exhibit the largest proportional decline at the highest urea level. The effects of increasing urea on duodenal N flow, microbial efficiency, ruminal contents, and fluid dilution rate were minimal. Ruminal ammonia N and molar percent acetate increased linearly (P < or = .02), whereas most other VFA (except propionate) decreased (P < or = .05) with increasing urea. In conclusion, although forage OM intake was not altered, OM digestion, NDF digestion, and DOMI were lowest when all supplemental DIP was supplied as urea. Changes in fermentation characteristics reflected the change in source of available nitrogen.

Ammonia↗
PubMed1997

Cerebrospinal fluid constituents collected at the atlanto-occipital site of xylazine hydrochloride sedated, healthy 8-week-old Holstein calves.

Cerebrospinal fluid (CSF) collected at the atlanto-occipital site and serum were obtained from 10 male, 8-week-old, Holstein calves after sedation with xylazine hydrochloride. Glucose, creatine kinase, alkaline phosphatase, urea nitrogen, creatinine, sodium, potassium, chloride, calcium, phosphorus, total protein, and albumin were determined in serum and CSF. Optical characteristics, specific gravity, total red blood cell and nucleated cell counts and differentials were also evaluated in the CSF. Additionally, CSF protein electrophoresis and immunoglobulin concentrations were determined. Then, albumin quotients (AQ) were derived. Erythrocytes were observed in 9 of 10 CSF samples. Total nucleated cell counts ranged from 0-10 cells x 10(6)/L with a mean of 3 cells x 10(6)/L. Differential nucleated cell count in the CSF consisted primarily of lymphocytes/small mononuclear cells (57%), fewer monocytes/ large mononuclear cells (38%), and scant neutrophils (4%) and eosinophils (0.05%). The concentration of sodium (134 to 139 mEq/L) was similar to that of serum, but the concentration of potassium (2.8 to 3 mEq/L) was lower than that of serum. Creatine kinase activity (0 to 4 U/L) of CSF was markedly lower than serum activity. The CSF glucose concentration was approximately 80% of the serum value. Cerebrospinal fluid total protein concentration determined by electrophoresis ranged from 110 to 330 mg/L with a mean of 159 mg/L. Cerebrospinal fluid albumin ranged from 48 to 209 mg/L with a mean of 86 mg/L. In all CSF samples, radial immunodiffusion of unaltered CSF and concentrated CSF (four-fold concentration) revealed quantities undetectable by the present techniques in which the lowest standard values for IgG1, IgG, and IgM determinations was 70 mg/L and IgG2 was 30 mg/L. The albumin quotient ranged from 0.15 to 0.65 with a mean of 0.25. Based on the results of this study, CSF may be collected at the atlanto-occipital site safely and efficiently in calves, and reported values for CSF from adult cattle may not be suitable for evaluation of CSF collected from immature cattle.

Alkaline Phosphatase↗
PubMed1996

Treatment of clinical paratuberculosis in cattle.

Paratuberculosis is a chronic, fatal condition that is usually clinically undetectable until the onset of copious diarrhea. Paratuberculosis is caused by Mycobacterium paratuberculosis. Successful eradication of paratuberculosis depends on the early detection of infected animals, allowing removal of carrier animals from the herd. Treatment for paratuberculosis is therefore rarely indicated or undertaken. Treatment may, however, be considered in ruminants of exceptional genetic value or in companion animals.

Animals↗
PubMed1996

Diagnosis and management of tendon disorders in cattle.

Diagnosis and treatment of congenital and acquired tendon disorders in cattle are discussed. A brief discussion of tendon structure, anatomy, biomechanics, and healing is included. Congenital abnormalities presented include hyperextension deformities, flexural deformities, arthrogryposis, and spastic paresis. Acquired abnormalities discussed include tendon displacement, tendinitis, tendon disruption, and tenosynovitis. Antibiotic selection for musculoskeletal infections is briefly discussed.

Animals↗
PubMed1996

External skeletal fixation in ruminants.

External skeletal fixation (ESF) techniques are increasingly being adapted for treatment of fractures in large animals. This article includes detailed information regarding decision making for ESF, biomechanics of ESF, interaction of the bone and implants, general surgical techniques for application of ESF (including traditional ESF, use of acrylic sidebars for ESF, and transfixation, pinning, and casting), discussions of application of ESF to specific bones, and complications associated with the use of ESF. Also, techniques for the management of open, infected fractures are presented. Future directions of ESF research and application also are presented.

Animals↗
PubMed1996

Amputation and prosthesis.

Amputation of a limb is a drastic therapy in cattle and should be considered as a last resort in the treatment of limb injuries. Even though the surgical technique for amputation is simple, daily limb management, prosthesis manufacture, and adaptation of the animal to the prosthesis are difficult and time consuming. Dedication of the owner to the aftercare required for the rest of the animal's life is extremely important. Amputation of a limb with prosthesis application is a method of saving valuable animals for breeding purposes or animals of sentimental value. The author reviews his experience with partial foreleg amputation and prosthesis application in three heifers.

Amputation, Surgical↗
PubMed1996

Surgical management of digit disorders in cattle.

Digital diseases in cattle are common. Cattle affected by digital disorders do not always respond to medical therapy and often need surgery. A thorough examination of the digits and radiographic evaluation help the clinician to choose the appropriate treatment and surgical approach. Age, sex, weight, type of production, and environment of the cattle also should be considered in choice of therapy.

Amputation, Surgical↗
PubMed1996

In vivo and in situ measurements of forage protein degradation in beef cattle.

In vivo and in situ protein degradation measurements were compared using alfalfa (2.62% N) and prairie hay (.88% N) fed to six cannulated cows in a two-period crossover experiment. Additionally, two in situ procedures were evaluated: in P1 samples were ruminally incubated in cows fed the same forage as incubated; in P2 samples were incubated in the rumens of two steers fed a "standard" brome hay (1.38% N). Duplicate bags were incubated for 0, 2, 6, 10, 16, 24, 48, and 72 h. Protein degradability was estimated using residual N from all incubation times fit to a nonlinear, least squares model (full time-series), from the 16-h incubation alone (single-point) and from a combination of the 0-h and 16-h values (double-point). Protein degradability estimates from in vivo, in situ P1, in situ P2, single-point P1 and P2, and double-point P1 and P2 were 83.4 +/- 4.3, 91.5 +/- .6, 87.2 +/- .6, 94.0 +/- .2, 92.4 +/- .8, 90.4 +/- .4, and 88.3 +/- .5, respectively, for alfalfa, and 55.5 +/- 3.5, 58.3 +/- 1.3, 57.2 +/- .4, 50.0 +/- 1.7, 52.0 +/- 2.2, 55.5 +/- 2.1, and 60.0 +/- 2.3, respectively, for prairie hay. Although relatively large differences in rates of degradation and sizes of protein fractions were measured between P1 and P2, differences between procedures for protein degradability estimates were small relative to errors of in vivo measurement. Furthermore, differences in protein degradation using single-point values as compared with full time-series analysis were overcome with the double-point approach.

Animal Feed↗
PubMed1995

Male reproductive surgery.

Copulation failure in food animals can be economically devastating to producers. Many pathological conditions can result in the inability of an animal to breed. In this article, diagnosis, pathophysiology, and treatment of penile and preputial injuries and anomalies, and inguinal hernias are presented. Surgical procedures are described for castration, seminal vesiculitis, circumcision, preputial diverticulectomy, penile hematoma, inguinal herniorrhaphy, phallorrhaphy, correction of filling defects of the corpus cavernosum, fibropapilloma, persistent penile frenulum, penile hair ring, and urethral fistulae.

Animals↗
PubMed1995

Influence of processing supplemental alfalfa on intake and digestion of dormant bluestem-range forage by steers.

Four ruminally and duodenally fistulated, 2-yr-old Angus x Hereford steers (average initial BW = 370 kg) were used to evaluate the effect of method of processing supplemental alfalfa on intake and digestion of dormant bluestem-range forage (2.8% CP, 78% NDF). Treatments (4 x 4 Latin square) were 1) control, no supplement; 2) ground and pelleted alfalfa hay (PELLET; 21% CP, 37% NDF); 3) ground and pelleted dehydrated alfalfa (DEHY; 21% CP, 44% NDF); and 4) longstem alfalfa hay (HAY; 20% CP, 37% NDF). All supplements were from a single cutting of alfalfa and fed at .5% BW (as-fed basis). Supplementing steers with alfalfa increased (P < or = .07) bluestem forage OM intake (FOMI); total OM intake (TOMI); true ruminal OM digestibility; total tract OM digestibility (TTOMD); total N, microbial N, and nonammonia-nonmicrobial N (NANM) flows to the duodenum; ruminal OM and fluid fill; fluid dilution rates; dietary DE concentration; and ruminal total VFA and NH3 N concentrations. Because of the enhanced FOMI and TOMI associated with alfalfa supplementation and the concomitant improvement in TTOMD, digestible OM intake (DOMI) also increased (P < .01) when supplemental alfalfa was fed. Method of processing alfalfa had little impact on forage utilization, except FOMI (P = .11), TOMI (P = .10), and ruminal OM fill (P = .09) tended to be greater when supplemental alfalfa pellets were dehydrated. Similarly, processing method tended to alter the molar proportions of some minor VFA. In conclusion, alfalfa supplementation exerted a dramatic impact on utilization of low-quality forage.(ABSTRACT TRUNCATED AT 250 WORDS)

Animal Feed↗
PubMed1995

Evaluation of a porous bovine collagen membrane bandage for management of wounds in horses.

OBJECTIVE: To evaluate the effect of a porous bovine-derived collagen membrane (PBCM) on the rates of wound healing, cellular events, presence of granulation tissue, and appearance at termination of the study in surgically created full-thickness cutaneous wounds of the distal portion of the extremities of horses. DESIGN: Treated wounds (n = 12) received a PBCM dressing and control wounds were covered with a nonadherent dressing. Forelimbs and hind limbs were cross paired; the right forelimb and left hind limb always received the same dressing application, as did the left forelimb and right hind limb. Limbs pairs were then randomly assigned to 1 of the 2 dressings. ANIMALS: Six healthy male horses (3 sexually intact, 3 geldings) ranging from 2 to 10 (mean, 6.5) years and weighing between 278 and 568 (mean, 408.5) kg were studied. PROCEDURE: Full-thickness skin wounds (6.25 cm2) were created on the dorsal metatarsi and metacarpi of the experimental animals. A preformed PBCM dressing was evaluated in half the wounds (n = 12). Control wounds (n = 12) were dressed with a nonadherent gauze dressing. At each bandage change, wounds were subjectively assessed and were photographed, and measurements of horizontal and vertical wound dimensions were documented. Wound biopsy specimens obtained on days 2, 5, 7, 10, 21, and 31 were evaluated for presence of collagen, fibrin, inflammation, epithelium, and cellular elements of healing. Planar morphometry was used to determine total wound area and granulation area from the wound photographs. Percentage of contraction and epithelialization were calculated from these values. Linear regression analysis of the square root of the total wound area and the granulation area was performed. Wound area measurements were analyzed, using ANOVA for repeated measures. Regressions were compared, using covariance analysis and ANOVA. Significance was considered at P < 0.05. RESULTS: Fibrin score, neutrophil score, and degree of inflammation were significantly greater in the PBCM-treated wounds. No significant differences in the total wound, epithelialized, or contraction areas were detected between the PBCM-treated and control (nonadherent-treated) wounds. Rates of wound healing were not statistically different between the 2 treatment groups, though they were significantly slower in the hind limbs, compared with the forelimbs. Scabs were formed more frequently in the PBCM-treated wounds. CONCLUSIONS: Application of a porous collagen bandage was not detrimental to full-thickness cutaneous wound healing in horses.

Analysis of Variance↗
PubMed1994

Persistent dorsal displacement of the soft palate in two young bulls.

Dorsal displacement of the soft palate was diagnosed by means of endoscopy and radiography in a 10-month-old Chianina/Angus bull and an 11-month-old Limousin bull. Both bulls produced respiratory noise that was audible in all phases of respiration. The Limousin bull also had exercise intolerance and became dyspneic when excited. The Chianina/Angus bull was treated with anti-inflammatory medication and rest. The respiratory noise resolved over a 4-month period, and the Chianina/Angus bull has been breeding successfully on pasture. Sternothyroideus and sternohyoideus myectomy was performed in the Limousin bull. Immediate postoperative improvement was noticed clinically and endoscopically. The bull had normal respiration 4 months after surgery and was successfully breeding on pasture. Although rare, dorsal displacement of the soft palate should be considered when evaluating cattle with respiratory noise or exercise intolerance.

Animals↗
PubMed1994

Effects of slaframine and 4-diphenylacetoxy-N-methylpiperidine methiodide (4DAMP) on pancreatic exocrine secretion in the bovine.

Three Holstein steers (345 +/- 22 kg) surgically fitted with a pancreatic cannula were used in two 3 x 3 Latin square design experiments to examine the effects of slaframine (SF), a muscarinic agonist, or 4-diphenylacetoxy-N-methylpiperidine methiodide (4DAMP), an M3 muscarinic glandular receptor antagonist, on pancreatic exocrine secretion. Pancreatic exocrine secretion was collected for 8 h postdosing at 30-min intervals beginning 1 h postfeeding. In experiment 1, steers were dosed with 0, 25, or 50 micrograms.kg-1 body weight (BW) of SF. Secretion of pancreatic juice and the pH of the secreted juice increased linearly (p < 0.05) with SF; however, secretion rate showed a time by treatment interaction (p < 0.05), as treatments converged 7 h postdosing. Trypsin secretion tended (p < 0.10) to show a quadratic response to SF administration, with the 25 micrograms SF.kg-1 BW dose having the lowest value. In experiment 2, steers received 50 micrograms.kg-1 BW of SF (positive control), 113 micrograms.kg-1 BW of 4DAMP (isosmolar with SF), or both. SF caused a greater pancreatic fluid secretion (p < 0.10) than 4DAMP, with SF plus 4DAMP intermediate. A time by treatment interaction (p < 0.04) was found, since treatments converged 8 h postdosing. Trypsin secretion was higher (p < 0.05) for SF than the other treatments. Chymotrypsin, alpha-amylase, and protein secretion were not affected. SF and 4DAMP alter pancreatic fluid secretion in the steer but have minimal effects on enzyme secretions.

Alkaloids↗
PubMed1994

Effects of chemical restraint on the endoscopic appearance of laryngeal and pharyngeal anatomy and sensation in adult cattle.

Effects of 2 drugs commonly used for chemical restraint of cattle were evaluated for their effect on laryngeal and pharyngeal anatomy, function, and response to stimuli. Eighteen adult Jersey cows, free of respiratory tract disease, were studied. Cows were assigned at random to 1 of 3 treatment groups. Endoscopic evaluations were performed before and at a predetermined time interval after administration of each drug. Responses to stimuli were evaluated by stimulating 7 preselected sites (epiglottis, left and right arytenoid cartilages, left and right vocal folds, and left and right dorsolateral pharyngeal walls) with a closed, transendoscopic biopsy probe. Xylazine HCl (0.05 mg/kg of body weight, i.v.) was administered to group-1 cows (n = 6), and endoscopy was repeated 5 minutes after administration of the drug. Xylazine (0.07 mg/kg, i.v.) was administered to group-2 cows (n = 6), and endoscopy was repeated 5 minutes after administration of the drug. Acepromazine maleate (0.035 mg/kg, i.v.) was administered to group-3 cows (n = 6), and endoscopy was repeated 10 minutes after administration of the drug. Responses to stimuli were scored as brisk (0), moderate (1), slow (2), and absent (3). Scores for responses to stimuli were compared, using the Wilcoxon signed-rank test for data within groups, and a general linear models procedure, using the Kruskal-Wallis test between groups. Interobserver agreement rates were generated for each group. A value of P < 0.05 was considered significant. Xylazine profoundly changed laryngeal sensitivity and function at both dosages. The corniculate processes of the arytenoid cartilages were observed to be in a markedly adducted position after sedation.(ABSTRACT TRUNCATED AT 250 WORDS)

Acepromazine↗