[Coagulation disorders in urosepsis].
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Biomedical subjects
Publications and source records attributed to G Staehler.
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Experience in the treatment of 167 testicular tumors is reported in 164 patients who were hospitalized during the last 15 years. Seminoma patients were irradiated postoperatibely, teratoma patients since 1965 have been subjected to radical lymphadenectomy and also irradiated postoperatively if there was confirmed evidence of metastases. The total survival rate was 58.6 percent. Cytostatic therapy was used in only a few cases: convincing remission could not be observed. The favorable results so far obtained with lymphadenectomy justify the continuation of surgical treatment.
70 nonselcted patients with prostatic carcinoma underwent coagulation analysis. Sxi had typical evidence of diffuse intravascular coagulation and in 8 cases such a disorder was highly probable. In 3 patients coagulation alterations appeared only after estrogen treatment, 17 patients (24.3%) thus showed evidence of intravascular coagulation. The hemostatic distrubance was silent in all but 3 cases where bleeding occurred. Coagulation disorders were found mainly in advanced stages and poorly differentiated carcinomas. There was a much higher content of thromboplastic activity in prostatic carcinoma than in normal prostatic tissue. Heparin plays a predominant role in the treatment of the coagulation disorder. In addition to therapy of clinically maifest consuption coagulopathy heparin can be used in prophylaxis against bleeding and thrombosis in cases with clinically silent intravascular coagulation and also in estrogen treatment.
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