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Biomedical subjects

G Stake

Publications and source records attributed to G Stake.

At least 37 records · Page 2Linked to original sources
PubMed1983

Iohexol and metrizamide for urography in infants and children.

The new non-ionic contrast medium iohexol, was compared with metrizamide in a double blind investigation. Urography was performed in 40 children below 6 years of age. Adverse reactions were negligible. A small decrease in erythrocyte volume fraction (hematocrit) values after the injection was found in both groups. Excellent films were obtained in most patients and no difference in diagnostic quality between the two media was observed.

Child, Preschool↗
PubMed1982

Nephroblastomatosis.

Explore the source record for details and available documents.

Diagnosis, Differential↗
PubMed1981

Metrizamide and metrizoate for cardioangiography in infants and children.

Metrizamide was compared with metrizoate in a double blind investigation. Cardioangiography was performed in 30 infants and children below 2 years of age with congenital heart disease. Adverse reactions were few and unimportant. Changes in ECG, ventricular pressure and heart rate during and after the contrast injections were recorded. The side effects were slight in both groups. Metrizamide caused less changes than metrizoate at a statistically significant level.

Blood Pressure↗
PubMed1981

Tricuspid atresia corrected with valved xenograft conduits.

In eight patients from 1976 until 1980, tricuspid atresia (TA) was corrected with valved xenograft conduits between either the right atrium and the main pulmonary artery or between the right atrium and the rudimentary right ventricle. All patients suffered from transient right-heart failure postoperatively and eventually developed normalized cardiac function throughout the first two months after operation. At recatheterization one year postoperatively, the right atrial pressure had generally only increased slightly, the pulmonary artery pressure was normal in all patients and only minor pressure differences were present across the valved conduits. X-ray examination showed normalization of the heart size in the majority of the patients, and in those with conduits between the right atrium and the right ventricle a considerable enlargement of the right ventricular chamber together with normalization of right ventricular contractility had developed. Arterial oxygen saturation, haemoglobin and haematocrit valves had normalized in all patients. One patient died postoperatively of intractable right ventricular failure, septicaemia and intravascular coagulation, and another was uneventfully re-operated on two years postoperatively because of conduit thrombosis. Clinical results were gratifying. Two patients with valved conduits between the right atrium and the right ventricle showed a normal unrestricted level of activity without medication, while patients with valved conduits between the right atrium and the main pulmonary artery were digitalized with an almost normal level of activity. Early repair with valved conduits of patients with TA is advocated.

Angiography↗
PubMed1979

"Balloon valvulotomy" of congenital pulmonary valve stenosis with tricuspid valve insufficiency.

The rare congenital anomaly of pulmonary valve stenosis and massive tricuspid valve insufficiency with intact ventricular septum is a lethal condition without reported survival after attempted treatment. In a neonate suffering from this syndrome, the pulmonary valve stenosis was relieved by rupturing the fused valve with a balloon catheter introduced transvenously. The desperate condition of the patient quickly improved after this procedure, with subsequent disappearance of the tricuspid valve incompetence. Balloon rupturing of fused valves at angiography may represent a therapeutic alternative in cases in which surgical valvulotomy is associated with a high mortality.

Cardiac Catheterization↗
PubMed1977

Relation between left ventricular filling pressure and angiographic findings in coronary heart disease. Ventriculography used as a stress test.

In 80 male patients with coronary heart disease maximum diastolic pressure in the left ventricle (LVMDP) (usually the top of the a wave), and 'post a' end-diastolic pressure (LVEDP) before and 2 and 3 minutes after ventriculography were correlated to angiographic estimates of left ventricular function (aneurysm, ejection fraction (EF), and to lesions shown by selective coronary arteriography using a score system (coronary artery lesions index, CALI). A significant correlation between CALI and LVEDP (or LVMDP) could not be shown either before or after ventriculography. Before ventriculography, however, LVEDP and LVMDP were good predictors of left ventricular dyskinesia (aneurysm and/or EF less than 50%). A positive and significant correlation between CALI and the LVEDP (and LVMDP) increments following ventriculography (delta LVEDP, delta LVMDP) was found in patients with LVEDP (or LVMDP) below 12 mmHg before ventriculography. Using delta LVEDP the correlation coefficient was 0-51 (n = 41, P less than 0-001, 95 per cent confidence interval 0-24 to 0-88). Using delta LVMDP r = 0-47 (n = 41, 0-001 less than P less than 0-01). Delta LVEDP greater than 12 mmHg was found only in patients with triple vessel disease.

Adult↗
PubMed1976

P wave terminal force and persisting ST elevations in chronic ischemic heart disease. Prediciton of left ventricular motility and diastolic pressure.

In 80 male patients with coronary heart disease P terminal force in V (V Ptf) was correlated with left ventricular end-diastolic pressure (LVEDP) and the findings by left ventricular angiography (ejection fraction (EF) and signs of aneurysm). The correlation between V Ptf and LVEDP was statistically significant (r= - 0.56, n= 80, p less than 0.001). Abnormal V Ptf ( less than -0.03 mm. second) used to detect LVEDP greater than 12 mm. Hg gave sensitivity 59 per cent (22 of 37) and specificity 88 per cent (5 of 43 false positive). The mean V Ptf in 26 patients with aneurysm and/or EF Less than 50 per cent (dyskinesia group) was -0.058 mm. second in contrast to -0.021 in patients with EF greater than 50 per cent (p less than 0.001). Abnormal V Ptf was a more sensitive parameter in separating the dyskinesia group from the others than abnormal ST elevations (sensitivity 73 vs. 54 per cent, respectively); but less specific (83 vs. 98 per cent). In this respect the specificity of V Ptf increases inversely proportionally to the V Ptf value. Both of these electrocardiographic parameters may be useful in the primary selection of patients suited for surgical treatment of coronary heart disease.

Adult↗
PubMed1976

Chronic myocardial disease. II. Haemodynamic findings related to long-term prognosis.

Haemodynamic findings in 106 patients with chronic myocardial disease have been related to the course of the disease during a follow-up period of 2-12 years. A high filling pressure, especially when combined with low cardiac output, suggested a severe development. The worst outlook was noted in patients who in addition had raised pulmonary arteriolar resistance. On the other hand, a low filling pressure even if cardiac output was reduced, was generally associated with a more benign course. An increase in left ventricular wall thickness as determined angiographically suggested a better outlook than normal wall thickness.

Blood Pressure↗
PubMed1976

Lung complications during immunosuppressive treatment in renal transplant recipients.

Pulmonary complications among 77 renal transplant recipients have been analysed. In the immediate postoperative period complications occurred with the same frequency as after other operations. Later on, usually within 6 months, pneumonia caused by bacteria, Pneumocystis carinii, cytomegalovirus and fungi occurred. The lung changes may indicate the underlying infecting organisms. Mortality from pneumonia was 14% (11/77) including two patients with lung aspiration following emergency surgery. Pulmonary complications were significantly higher in men.

Adolescent↗
PubMedDate not supplied

Iohexol and metrizamide for urography in infants and children.

The new nonionic contrast medium iohexol, was compared with metrizamide in a double blind investigation. Urography was performed in 40 children below 6 years of age. Adverse reactions were negligible. A small decrease in erythrocyte volume fraction (hematocrit) values after the injection was found in both groups. Excellent films were obtained in most patients and no difference in diagnostic quality between the two media was observed.

Child, Preschool↗
PubMedDate not supplied

Influence of urography on renal function in children. A double blind study with metrizoate and iohexol.

Thirty-two children were given either metrizoate or iohexol for urography in a double blind study. Mild to moderate adverse reactions were observed in all patients receiving metrizoate (15/15) and in 4 receiving iohexol (4/17). Alkaline phosphatase in urine was significantly increased 4 hours after the injection of both media, but had returned to pre-injection levels 16 hours later. The excretion of beta 2-microglobulin and albumin was not altered. In 9 children in the metrizoate group and 11 in the iohexol group the glomerular filtration rate (GFR) was determined before urography by the single injection 99Tcm-DTPA-technique and 3 to 4 hours after urography by measuring the plasma disappearance of the contrast medium with the x-ray fluorescence technique. No reduction of GFR was observed.

Adolescent↗