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Biomedical subjects

G Stange

Publications and source records attributed to G Stange.

At least 73 records · Page 4Linked to original sources
PubMed1977

[The effects of intratympanally applied streptomycin-sulfate on the ipsi- and contralateral hearing potentials in the guinea pig (author's transl)].

11 Guinea pigs had a 50% streptomycin-sulfate solution injected into the middle ear. Complete loss of function of the peripheral vestibular organ occurred after two days, as was detectable by means of the caloric test. The high-degree decrease of the microphonic-potentials and the compound action potential was significant. Threshold and adaptation of the potentials of the opposite side were not affected. The results are discussed with regard to the treatment of Menière's disease by means of intratympanally applied streptomycin.

Action Potentials↗
PubMed1977

Does promethazine (Atosil) influence the human's early acoustically evoked potentials in the same way as the late potential N1?

In a former investigation the effect of promethazine (Atosil) on the late acoustically evoked potential component N1 was examined. Now the cochlear and the brain-stem potentials were registered by the earlobe-vertex pick-up with i.m. application of 0.8 mg/kg (body weight) promethazine. There was no influence of promethazine either on the compound action potential (NAP) or on the brain-stem potentials (Pot. II-V), but sedation improves significantly the signal-to-noise ratio, therefore we sedate all patients when registering the five early acoustically evoked potentials.

Acoustic Stimulation↗
PubMed1977

[Toxic diseases of the inner ear (author's transl)].

A clear presentation of toxic diseases of the inner ear under consideration of the endogen and exogen factors is shown by means of tables as well as clinical findings and experimental results obtained in animals.

Adult↗
PubMed1976

[The activity of motor units of the musculus splenius capitis in pheripheral vestibular lesions (author's transl)].

The activity of single motor units of the splenius-capitis muscle of healthy human subjects and patients with unilateral vestibular lesions was recorded by means of microelectrodes. The major part of these units reacted to vestibular stimulation in the same way as primary and secondary vestibular neurones of other vertebrates. The reactions of these units to trapezoidale stimuli is identical to that of vestibular neurones. An angular acceleration of more than 0.6 degrees/s2 is for these units a stimulus which is above threshold, this too corresponds to findings in the vestibular nerve. In patients with unilateral vestibular lesions the threshold for rotatory stimuli is markedly increased on the side of the lesion, whereas the threshold on the other side remains constant. This method is very sensitive and vestibular lesions can be detected which cannot be seen using the common technics for vestibular examination.

Action Potentials↗
PubMed1976

Input-output function and adaptation behaviour of the five early potentials registered with the earlobe-vertex pick-up.

At twenty-three 20-30-year-old normal-hearing subjects the characteristic curves of amplitudes and latencies of the five early potentials, appearing within the first 8 ms after stimulus onset, were obtained. The potentials were registered with the earlobe-vertex pick-up, as described by Sohmer and with click stumulus rates of 5/sec, 10/sec and 100/sec; It could be seen: All five potentials depend in amplitude and latency on intensity; all potentials show with increasing click rate an adaptation and a delayed latency, when increasing the click rate from 10/sec to 50/sec; the adaptation phenomenon of the 1st, 2nd, 3rd and 4th potential is the most prominent, the 4th potential shows the smallest adaptation effect; the characteristic curve at 10/sec of the 1st and 3rd potential demonstrates a break at 70 dB SPL; the latencies of the five potentials begin to increase at click rates higher than 10/sec; the 4th potential seems to be the most suitable one for measuring the acoustical threshold; only the fifth potential diminishes in amplitude and increases in latency after administration of an anaesthetic, but an additional relaxant does not alter it any more.

Acoustic Stimulation↗
PubMed1976

[Topodiagnostic ERA results at a female patient with multiple sclerosis in the brainstem (author's transl)].

At a female patient suffering from multiple sclerosis with demyelinisation mainly in the pontine and mesencephalic tegmentum, the five early potentials consisting of the compound action potential of the acoustic nerve (Pot. I) and the four brainstem potentials (Pot. II-V) as well as the slow evoked vertex-potential were registered. The threshold behaviour, the characteristic curve and the latency curve of all potentials were obtained, and thereby damages of the central acoustic pathways found out. A topodiagnostic is tried by means of the alterations of the peripheral and central ERA, and by means of the informations described in the literature. A control registration, carried out four weeks later, demonstrated an improvement of the diagnosis.

Audiometry↗
PubMed1976

[Adaptational behaviour of peripheral and central acoustic responses in guinea pigs under the influence of various fractions of an extract from Gingko biloba (author's transl)].

Experimental studies on 114 guinea pigs proved definitely the influence of an extract from Ginkgo biloba batch no. 02 on the acoustic system. Experiments with animals ensured that the adaptation of excitation of the organ of Corti is significantly influenced. This result is shown by registrations of the acoustic nerve potentials in the adapted and nonadapted state. The relation of excitation to adaptation is significantly changed. Under adaptation of excitation an influence on the metabolism of involution is probable. The slow evoked potentials of the acoustic cortex showed no additional influence on the central auditory pathways. With the Ginkgo biloba extract it is probably possible to diminish sound damages caused by white noise. Further experiments on animals are necessary to ensure the application of this pharmaceutical preparation for clinical use.

Acoustic Stimulation↗
PubMed1975

[Connective tissue-silicone foils-tympanoplastics in cases of adhesive processes of the middle ear (author's transl)].

In 1970-1974, tympamoplastics of type I-III were done in 95 patients with adhesive processes of the middle ear (epithelized tympanon, scarred adhesions of the chain, sclerosis of the tympanon etc.) following chronic inflammation or cholesteatoma. In order to avoid renewal of adhesions, to make possible the growth of mucosa and to obtain pneumatisation of the middle ear, 1 to 3 pieces of silicone foil were inserted to each patient into the middle ear. In 21 patients the silicone foil was removed. Technique of insertion and problems of removal of the foil as well as audiollogical postoperative results are demonstrated and discussed.

Audiometry↗
PubMed1975

[The influence on sound damages by an extract of ginkgo biloba (author's transl)].

A fraction of Ginkgo biloba, used in experiments with animals ensured significantly the diminution of sound damages caused by white noise or by a pure tone of 4.5 kHz. Higher amplitudes of the acoustic nerve potentials show the protective effect of this fraction of Ginkgo biloba at acute sound damages. It is moreover possible to hold physiologically the adaptation of excitation of the hair cells of the organ of Corti by the fraction of Ginkgo biloba before and after sound damage caused by white noise or during a pure tone of 4.5 kHz. The influence of the fraction of Ginkgo biloba can be seen by a significantly slower recovery of the noise damaged evoked potentials of the acoustic cortex. An efferent protective influence on the neurons of the acoustic cortex is discussed. The fraction of Ginkgo biloba in this form of solution has not been tested for clinical use but it seems to be rich in meaning.

Animals↗