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Biomedical subjects

G Stathopoulos

Publications and source records attributed to G Stathopoulos.

13 recordsLinked to original sources
PubMed1978

In vitro comparison of kanamycin, kanendomycin, gentamicin, amikacin, sisomicin, and dibekacin against 200 strains of Pseudomonas aeruginosa.

The antimicrobial activity of kanamycin, kanendomycin, gentamicin, amikacin, sisomicin, and dibekacin against 200 strains of Pseudomonas aeruginosa was compared. Dibekacin was found to be the most active against the tested organisms, whereas the other aminoglycoside antibiotics fell in the following order of diminishing antibacterial potency: amikacin, sisomicin, gentamicin, kanendomycin, and kanamycin. Seven strains showed high-level resistance to gentamicin (minimal inhibitory concentration, 400 mug/ml), and two of them were also resistant to amikacin and sisomicin (minimal inhibitory concentration, 75 mug/ml). The minimal inhibitory concentration of dibekacin for these seven strains was 0.625 mug/ml.

Dibekacin↗
PubMed1977

Description of the cells from the lymph nodes of patients with non-Hodgkin's lymphoma according to some B- and T-cell characteristics.

The lymph node cell populations from 24 patients with non-Hodgkin's lymphoma were investigated for some of the surface characteristics which are used as T- and B-lymphocyte markers. Nineteen of the patients had had no treatment of any kind while the other 5 had had either recent radiotherapy or chemotherapy. Seven lymph nodes from patients without malignant disease and 7 others with reactive changes were also studied. It was found that lymphocytic lymphomas, nodular or diffuse, well or poorly differentiated, had a high proportion of cells which were positive for B-cell markers. Other non-lymphocytic lymphomas had a higher proportion of cells positive for T-cell markers, and were similar to the cells from non-malignant lymph nodes.

B-Lymphocytes↗
PubMed1977

The T and B lymphocyte content of lymph nodes and spleen in Hodgkin's disease.

Lymphocytes from tumour-bearing lymph nodes in 15 patients with Hodgkin's disease, and lymphocytes from 6 spleens infiltrated by Hodgkin's tissue and 6 tumour-free spleens were studied using T and B lymphocyte markers. For comparison, lymphocytes from 16 tumour-free lymph nodes were similarly assessed. It was found that the tumour-bearing nodes showed a predominance of T lymphocytes compared with the control nodes, whereas in involved splenic tissue the proportion of T lymphocytes was slightly reduced compared with uninvolved spleens.

B-Lymphocytes↗
PubMed1977

Pharmacokinetics of five cephalosporins in healthy male volunteers.

This paper deals with data on the pharmacokinetics of cephazolin, cephalothin, cephapirin, cephaloridine and cephradine after i.m. injection of a single dose of 0.5 g in healthy male volunteers. Peak serum concentrations occurred 45 min after the administration and were 31.52 microgram/ml for cephazolin, 17.32 microgram/ml for cephaloridine, 13.98 microgram/ml for cephapirin, 9.51 microgram/ml for cephradine and 8.60 microgram/ml for cephalothin. The average half-lives were found to be 2.07, 1.80, 0.98, 1.24 and 0.97 h, respectively. The percentage of protein binding was found to be 82 for cephazolin, 59 for cephalothin, 51 for cephapirin, 31 for cephaloridine and only 10 for cephradine, half an hour after drug administration. The total urine recovery of the above cephalosporins, within 24 h, was 91.9% for cephradine, 81.9% for cephaloridine, 73.3% for cephazolin, 69.5% for cephapirin and 51.2% for cephalothin.

Adult↗
PubMed1975

Lymphocyte: erythrocyte (L.E.) rosettes as indicators of the heterogeneity of lymphocytes in a variety of mammalian species.

Lymphocytes and red cells from various mammalian species have been mixed in vitro in conditions which favor their aggregation in the form of rosettes. The frequencies of rosette formation taken in conjunction with observations on surface bound immunoglobulin on the lymphocytes favor the interpretation that, in many species of animal, rosette formation can be used as an indicator of the thymic (T) or bursal equivalent (B) origin of lymphocytes.

Animals↗