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Biomedical subjects

G Steg

Publications and source records attributed to G Steg.

At least 55 records · Page 3Linked to original sources
PubMed1982

A mechanographic method for measurement of locomotor activity in rats. Effects of dopaminergic drugs and electric stimulation of the brainstem.

A simple treadmill arrangement has been developed to quantify the quadruped or hindleg locomotor activity in rats. The method provides information on the accumulated distance passed by the rat in the treadmill but also on the temporal distribution of locomotion and the stepping cycle. It can be used with intact rats but also during stereotaxically guided electric stimulation of the brain. The accumulated locomotion produced by apomorphine showed a partly linear relation to the dose and the results were comparable to those found with other methods. The locomotor effect of brainstem stimulation was enhanced by apomorphine. This method combines the advantages of several other methods and is well suited as a tool for the analysis of nervous regulation of locomotor activity.

Animals↗
PubMedDate not supplied

Physiological mechanisms and movement analysis in Parkinson's disease.

We present new ideas about motor control in the human central nervous system and about pathophysiological mechanisms of Parkinson's disease, and we describe the Posturo-Locomotion-Manual (PLM) method, which is a new technique utilizing optoelectronic camera recording for objective, fully quantitative, and standardized assessment of human motor performance. In the PLM test, recordings of body movements are made during a simple motor task, where the subject repeatedly moves a small object from its starting position on the floor to a shelf located at chin height a few steps forward. The duration of the postural (raising up), locomotor and the goal-directed manual phase of the forward directed body movement is automatically calculated by a small computer as well as the degree of coordination (simultaneity) of these phases. The technique has high resolution and has been used for clinical assessment of motor performance, drug testing, and so on, in neurological and geriatric practice.

Basal Ganglia↗