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G Steineck

Publications and source records attributed to G Steineck.

96 records · Page 6Linked to original sources
PubMed1986

Multiple myeloma in Swedish agricultural workers.

Increased risk of multiple myeloma was found among farmers in studies reported in the literature. A retrospective cohort study of Swedish agricultural workers is now presented. All 254417 men aged 20-69 years at the time of the national census in 1960, who stated that they were working in agriculture, formed the study cohort. The reference cohort consisted of 1725845 men otherwise gainfully employed. The cohorts were followed from 1 Jan 1961 until 31 Dec 1979. The cases of multiple myeloma were identified in the Swedish cancer register by computerized record linkage. The 568 cases found in the study cohort resulted in an estimate of the relative risk of 1.20 (95% confidence interval 1.09-1.33).

Adult↗
PubMed1985

Interferon therapy in disseminated renal cell carcinoma.

Twenty patients with pulmonary metastases of renal cell carcinomas have been treated in a randomized study with either leucocyte interferon in daily doses of 3 x 10(6) I.U.i.m or irradiation of both lungs in a calculated mean central dose of 10 Gy in 4 weeks in combination with bleomycin and vincristine. Most patients had a short time to progression of their disease. Three patients in the interferon group had complete response (CR) and partial response (PR) and one patient in the other group had PR. The numbers of patients in both arms of the study are too small to allow any conclusions whether beneficial effects are more frequent in one group than in the other, but there is a more favourable tendency in the interferon group.

Adult↗
PubMed1976

Role of the thymus in generation of lymphocyte functions. I. Demonstration of lymphocytes reactive to mitogens and allogeneic cells in the embryonic mouse thymus in organ culture.

The thymuses of 14-day-old CBA mouse embryos cultured for 14 days in organ cultures supplemented with mouse serum contained lymphocytes that were highly reactive to the mitogens concanavalin A (Con A) and leukoagglutinin (LA) and to irradiated allogeneic spleen cells in vitro. In contrast, thymocytes derived from fetal-calf-serum-supplemented organ cultures displayed much weaker responses to the two mitogens and little or no response to the allogeneic spleen cells. Control thymocytes obtained from 1-month-old CBA mice responded well to Con A but not to LA. The responses of these cells to allogeneic spleen cells were delayed compared with the organ-culture-derived cells, which responded promptly, with a maximum already on culture day 2-3. The results demonstrate that the organ culture system provides a convenient model for further study of the generation of immunoreactive cells in the mouse thymus.

Animals↗
PubMedDate not supplied

Bladder cancer in Sweden.

The survival of patients with bladder cancer has not improved significantly during the past decades in spite of new diagnostic methods and treatment modalities. This observation underlines the need for improved routines to ensure earlier detection of the disease by patients and doctors and thereby start the treatment sooner. The common finding of treatment failures in patients who have shown no sign of local recurrence but have undergone radical cystectomy indicates that subclinical metastases are primarily responsible for the poor outcome in most cases. This indicates that, in addition to radical surgery, effective chemotherapy is needed to counteract the systemic spread of the disease.

Humans↗
PubMedDate not supplied

Lymphedema and bladder-emptying difficulties after radical hysterectomy for early cervical cancer and among population controls.

The aim of the study was to acquire knowledge that can be used to refine radical hysterectomy to improve quality-of-life outcome. Data were collected in 1996-1997 by means of an anonymous postal questionnaire in a follow-up study of two cohorts (patients and population controls). We attempted to enroll all 332 patients with stage IB-IIA cervical cancer registered in 1991-1992 at the seven departments of gynecological oncology in Sweden and 489 population controls. Ninety three (37%) of the 256 women with a history of cervical cancer who answered the questionnaire (77%) were treated with surgery alone. Three-hundred fifty population controls answered the questionnaire (72%). Women treated with radical hysterectomy, as compared with controls, had an 8-fold increase in symptoms indicating lymphedema (25% reported distress due to lymphedema), a nearly 9-fold increase in difficult emptying of the bladder, and a 22-fold increase in the need to strain to initiate bladder evacuation. Ninety percent of the patients were not willing to trade off survival for freedom from symptoms. Avoiding to induce long-term lymphedema or bladder-emptying difficulties would probably improve quality of life after radical hysterectomy (to cure cervical cancer). Few women want to compromise survival to avoid long-term symptoms.

Adult↗