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Biomedical subjects

G Sterling

Publications and source records attributed to G Sterling.

9 recordsLinked to original sources
PubMed1999

A statewide system to track medical students' careers: the Pennsylvania model.

In 1994 the Commonwealth of Pennsylvania announced a statewide Generalist Physician Initiative (GPI) modeled after The Robert Wood Johnson Foundation's GPI. Three-year grants totaling more than $9 million were awarded to seven of Pennsylvania's medical schools, including two that had already received GPI grants from the foundation. Stimulated by these initiatives, the state's six allopathic and two osteopathic medical schools decided to work together to develop a collaborative longitudinal tracking system to follow the careers of all their students from matriculation into their professional careers. This statewide data system, which includes information for more than 18,000 students and graduates beginning with the entering class of 1982, can be used to evaluate the impact of the Pennsylvania GPI, and it also yielded a local longitudinal tracking system for each medical school. This paper outlines the concept of the system, its technical implementation, and the corresponding implications for other medical schools considering the development of similar outcomes assessment systems.

Career Choice↗
PubMed1993

Phytophotodermatitis: a visit to Margaritaville.

Phytophotodermatitis is a phototoxic eruption following contact with photosensitizing compounds and long-wave ultraviolet light. The most common phototoxic compounds are the furocoumarins contained in a wide variety of plants, especially of the Umbelliferae, Rutaceae, and Moracea families. Commonly occurring photosensitizing plants include citrus fruits such as limes and oranges and many vegetables, notably celery, parsnip, parsley, carrots, and dill.

Adult↗
PubMed1978

Esterase and malate dehydrogenase isozyme polymorphisms in 15 Artemia populations.

1. Starch gel electrophoresis of adult brine shrimps from 15 populations revealed little intrapopulation polymorphism in NAD-dependent malate dehydrogenase (MDH) isozymes or in the two fastest esterases (demonstrated with alpha-naphthyl propionate as substrate). 2. Interpopulation differences could be summarized as three different electrophoresis band patterns for the five- to seven-banded MDH isozymes and another three patterns for the two fastest esterases. 3. These differences in electrophoresis patterns divide the 15 Artemia populations into four categories (each containing one to seven populations) which may be distinguished by isozyme content and which are congruent with categories established by the criterion of reproductive isolation in an earlier study.

Animals↗
PubMed1977

The hemoglobins of Artemia salina. IV. A model for genetic control of hemoglobin 1, hemoglobin 2, and hemoglobin X.

Two loci account for all genetic variation resulting in difference in electrophoretic mobility in three hemoglobins (Hb1, Hb2, and HbX) in the hemolymph of the brine shrimp. Four alpha alleles and nine beta alleles have been studied. In shrimps of all genotypes and in electrophoresis in media with varying degrees of molecular sieving, Hb2 is approximately equidistant from Hb1 and HbX. A shrimp heterozygous at both loci has a three-banded Hb1, a four-banded Hb2, and a three-banded BbX. We conclude that Hb2 contains n alpha-polypeptides and n beta-polypeptides. Hb1 contains 2n alpha-polypeptides. HbX contains 2n beta-polypeptides. During electrophoresis, the three native hemoglobins undergo reversible dissociation to n subunits. Subunits with the same charge reassemble to migrate as molecules of the same size as the native molecules. Although there is no evidence for an additional polypeptide in the three hemoglobins, we cannot exclude such a possibility. If it exists, it is under three constraints: (1) it must be present in equal amounts in each of the three hemoglobins; (2) it must have the same molecular weight as the alpha- and beta-polypeptides; and (3) it must be free of genetic variation (detectable by electrophoresis).

Alleles↗
PubMed1977

The hemoglobins of Artemia salina. V. Genetic variation in hemoglobin 1, hemoglobin 2, and hemoglobin 3.

Electrophoretic mobilities of three hemoglobins (Hb1, Hb2, and Hb3) were studied in 15 populations of brine shrimps. Genetic segregation data support the model that Hb2 contains n alpha-polypeptides and n beta-polypeptides; Hb1 contains 2n alpha-polypeptides- Hb3 contains neither alpha- nor beta-polypeptides. There is no evidence of linkage of alpha and beta loci with each other or with the locus (or loci) which governs Hb3 or with the nonhomologous portion of the sex chromosomes. Hemoglobins of different populations may be hybridized in vitro by incubation at high temperature. Reversible dissociation to subunits which contain only one (alpha or beta) polypeptide occurs at 40 C (for Hb1) and at 50 C (for Hb2).

Alleles↗
PubMedDate not supplied

Chondroblastoma of the talus: a case report.

Chondroblastoma of bone is an uncommon condition that has a predilection for secondary ossification centers, particularly of the humerus, tibia, and femur. Treatment usually involves surgical curettage and autogenous bone graft. This article reports the case of a chondroblastoma affecting the talus of a young man and a minimally invasive surgical approach for the treatment of this lesion. The patient presented with an 18-month history of right ankle pain and swelling. The lesion involved most of the talar body, with 2.5-cm cortical erosion inferiorly at the posterior talocalcaneal facet. A lateral approach was made to the talus and a window was fashioned at the distal end of the sinus tarsi under fluoroscopic guidance to allow access to the lesion. This was curetted and the defect was filled with autogenous bone graft taken from the ipsilateral iliac crest. The patient underwent an uneventful recovery, and was asymptomatic at follow-up 24 months postsurgery. He had 75% movement at the subtalar joint, when compared with the contralateral foot.

Adult↗
PubMedDate not supplied

Ultrasonography in developmental hip dysplasia.

With the evolving use of ultrasonography, there has been an increasing emphasis on the technically oriented diagnosis of developmental hip dysplasia. Graf's alpha and beta angles and Harcke's bony rim percentage are two of the more common criteria, but their repeatability and reliability have not been well documented. Fifty-eight hip ultrasounds of 29 infants were measured independently by three physicians, and statistical analysis was performed. It was concluded that Graf's and Harcke's methods could be repeatable with training and frequent use of ultrasonography. Harcke's guidelines have a large equivocal zone, which limited their clinical usefulness. Graf's angles gave a better classification, but their clinical relevance has not been proven.

Bone Diseases, Developmental↗