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Biomedical subjects

G Sticht

Publications and source records attributed to G Sticht.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Phospholipids in fatal strangulations (author's transl)].

A comparison of phospholipid content of sera from heart blood and sinus blood from the brain with the rate of haemolysis in the blood samples, with age, sex, degree of arteriosclerosis and cause of death, showed a relationship with the cause of death in spite of wide dispersion of the single values. The remaining factors of the 145 unselected human cadavers, which were not putrefied, seemed to have no influence. Small amounts of haemolysis caused a decrease of phospholipid concentration whereas an extensive haemolysis clearly led to an increase. The results of 46 deaths by hanging confirmed the fundamental studies of Berg (1950, 1952), who demonstrated that an increased secretion of phospholipids during the strangulation process is to be interpreted as a vital phenomenon. Compression of cervical vessels resulted in statistically significant differences between phospholipid concentrations in serum of heart and sinus blood.

Adolescent↗
PubMed1980

[Results of toxicological investigations on vesparax-poisonings (author's transl)].

Concentrations of brallobarbital and secobarbital in 10 cases of acute Vesparax-intoxications are listed for blood, brain, liver, kidney, and muscle. Quantitative determinations in brain give information as to the time of acute poisoning. Muscle is a suitable organ to determine the resorbed quantity of the drug. As few as 10 Vesparax-tablets are enough to produce lethal poisonings.

Adult↗
PubMed1978

[Post mortem determination of bromureides (author's transl)].

Concentrations of carbromal, carbromide and bromisoval are determined in blood, urine, brain, kidney and muscle taken at autopsy from 41 fatal cases after overdosage of bromureides. In addition values of total bromine in blood are presented. Contents of total bromine can only lead to the deduction that a chronical abuse of bromureides is existent or not. Concentrations of bromureides and carbromide show a wide range according to the different time between taking the drug and death particularly in cases of pure carbromal intoxications which sometimes cause death after several days. In such cases quantitative determination of carbromide, a pharmacologically active metabolite of carbromal, is the only way to prove an acute carbromal intoxication. Especially in cases of additional foreign substances death may occur in early the phase of poisoning. Bromureides decompose post mortem by putrefaction a high degree so that the condition of the cadaver is important. Brain tissue is the most usable material for examination but other organs, particularly muscle and kidney, can be analysed with success. For differential diagnosis fatal cases are presented which were not caused by drug intake.

Brain Chemistry↗
PubMed1976

[Structure of bromine containing metabolites of carbromal (author's transl)].

Isolation of three bromine containing metabolites from human urine is described and their chemical structure is proved by comparison of their physical properties with those of synthetically prepared substances. 2-Bromo-2-ethyl-butyramide, a pharmacologically active product, is showed to be the most important bromine containing metabolite by volume. In 3-position hydroxylated metabolites of carbromal, 3-hydroxy-carbromal and 2-Bromo-2-ethyl-3-hydroxy-butyramide have same physical properties as the synthesized DL-threo--diastereomeres.

Bromine↗