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Biomedical subjects

G Szeleczky

Publications and source records attributed to G Szeleczky.

11 recordsLinked to original sources
PubMed1981

[Important cause for reoperations of the common bile duct: papillary stenosis].

The authors have surveyed 94 cases of stenosis of Vater's papilla diagnosed in 270 late reoperations. In their opinion in more than one third of the cases stenosis of Vater's papilla persisted even at the time of the first surgical interference, only it was not diagnosed and adequately solved. They are convinced that by the routine use of radiomanometry, in addition to intraoperative close circuit TV monitoring, by the correct interpretation of the data and adequate surgery, the number of late reoperations after surgery of the biliary tract can be considerably decreased. The procedure has been in use at the author's clinic since 1961.

Adult↗
PubMedDate not supplied

Pharmacokinetic and metabolic studies of vinpocetine on dogs. I. Pharmacokinetics.

The pharmacokinetics of tritiated vinpocetine has been studied on dogs. The drug, when administered orally, was readily absorbed from the gastrointestinal tract (T1/2 0.3 h) and underwent similarly fast distribution (T1/2 0.8 h) in the organism. The mean value of the elimination half-life was 8.2 h. Approx. 75% of the administered radioactivity was excreted with urine and feces within 72 h. The pharmacokinetics of the intravenously administered, labelled compound showed that a similarly rapid distribution but a somewhat slower elimination took place. Fecal and urinary excretion of radioactivity applied amounted to about 82%. Investigation of the distribution of radioactivity between plasma and blood cells revealed that the radioactivity content did not bind to the cellular fraction of the blood. Pharmacokinetic studies of the same design in the literature allowed us to make some comparison between dogs, rats and humans in respect to the kinetic behavior of labelled vinpocetine.

Animals↗
PubMedDate not supplied

Pharmacokinetic and metabolic studies of vinpocetine on dogs. II. Metabolism.

Metabolic studies of vinpocetine were carried out by analysing the excreta of dogs treated orally or intravenously with the labelled compound. Our studies including various extraction procedures, TLC and MS structure identification revealed that vinpocetine underwent rapid and extensive metabolism in the animal organism. Unchanged parent drug was excreted via urine and feces only in a small or negligible portion. The prevailing metabolite in both urine and feces was apovincaminic acid. Two minor metabolites were also identified: hydroxy-vinpocetine and dihydroxy-apovincaminic acid-glycine amide. Beside the chemical structures and relative abundances of metabolites found in dogs, qualitative data referring to the metabolites occurring in the feces of orally treated humans, are also presented.

Administration, Oral↗