A gas-liquid chromatographic (GLC) method has been developed for the separation and determination of dihydroergotoxine alkaloids (dihydroergocristine, dihydroergokryptine and dihydroergocornine), involving quantitative decomposition of the compounds catalysed by a metal surface. GLC was carried out with 2% Dexsil 300 on Gas-Chrom Q as stationary phase, with temperature programming. For the quantitation, phenylbutazone was used as the internal standard.

Catalysis↗

PubMed1975

Determination of 21-hydroxy corticosteroids in pharmaceutical preparations using the 4,5-dimethyl-o-phenylene diamine method.

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Hydroxycorticosteroids↗

PubMed1974

Analysis of steroids. XXIV. A specific method for the spectrophotometric determination of 17-ethynyl steroids.

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Contraceptives, Oral↗

PubMed1973

[Long-acting norcain: sensory motor blockade].

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Acetamides↗

PubMed1973

[Reaction of ketone-group-containing compounds with diethyl oxalate and analytic application of the reaction. 3. Alicyclic ketones and compounds containing more than one ketone group].

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Cyclohexanes↗

PubMed1972

New method for determination of 21-hydroxy corticosteroids.

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Hydroxycorticosteroids↗

PubMed1972

Analysis of steroids. XXI. A spectrophotometric method for the determination of 21-amino corticosteroids.

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Amines↗

PubMed1972

[Sensomotor blockade by protracted acting norcaine].

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Analgesia↗

PubMed1971

[Analytic methods for the determination of optimal parameters of pharmaceutical reaction. II. N-alkylation reactions].

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Acylation↗

PubMed1971

[Reaction of diethyl oxalate with compounds containing a ketone group and analytical application of this reaction. I. Determination of optimum parameters for the reaction].

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Chemical Phenomena↗

PubMed1971

[Reaction of diethyl oxalate with compounds containing a ketone group and analytical applications of this reaction. II. Aliphatic and aromatic ketones].

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Acetophenones↗

PubMedDate not supplied

Planar chromatography: current status and future perspectives in pharmaceutical analysis--I. Applicability, quantitation and validation.

The most important features of capillary action planar chromatographic methods are summarized. Certain properties such as ease in operation, sensitivity to experimental conditions, stationary and mobile phase selection, phase system optimization, separation efficiency and detection possibilities are discussed only briefly. Other aspects such as the applicability of planar chromatographic methods in pharmaceutical analysis, quantitation and validation are considered in more detail. The advantages and limitations of different evaluation techniques (visual comparison, spot elution techniques and in situ densitometry) are also discussed. Validation steps specific to planar chromatographic methods are emphasized.

Chemistry, Pharmaceutical↗