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G T Benness

Publications and source records attributed to G T Benness.

At least 37 records · Page 2Linked to original sources
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Solute excretion during intravenous urography: a comparison of sodium and methylglucamine iothalamates.

The sodium and methylglucamine salts of iothalamic acid were compared as urographic agents. The two drugs were administered intravenously to dogs at a dose of 600 mgI/kg. The outputs and concentrations of the major urinary solutes and the injected solutes were measured to define the differences in renal excretion of sodium and methylglucamine iothalamates. The action of methylglucamine as a relatively inert osmotic diuretic was reconfirmed. When sodium iothalamte was adminstered the tubular reabsorption of sodium and chloride was greater than when methylglucamine iothalamate was used. It is suggested that this reabsorption explains the advantage of sodium-linked agents over methylglucamine-linked agents in urography.

Animals↗
PubMedDate not supplied

Solute excretion during intravenous urography. A comparison of sodium iothalamate and sodium iocarmate (iothalamate dimer).

Sodium iothalamate and sodium iocarmate (iothalamate dimer) were compared as urographic agents. The two agents were administered intravenously to dogs at a dose level of 600 mg I/kg. The concentrations and outputs of major urinary solutes and injected solutes were measured to define the differences in diuretic effect of the two agents. The urinary output and concentration of iodine with each agent were also compared. The diuresis with iocarmate was lower. It was apparent that the lower diuresis and higher urinary iodine concentration with iocarmate was due to the lower osmotic activity per iodine atom obtained with this agent.

Animals↗